IMMUNOFLUORESCENT DETECTION OF MEASLES-VIRUS ANTIGENS IN CEREBROSPINAL-FLUID CELLS IN SUBACUTE SCLEROSING PANENCEPHALITIS

The Lancet ◽  
1971 ◽  
Vol 297 (7705) ◽  
pp. 891-892 ◽  
Author(s):  
A.D. Dayan ◽  
MollieI. Stokes
Keyword(s):  
Cerebrospinal Fluid ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Cerebrospinal Fluid Cells ◽  
Virus Antigens

Diagnosis of Subacute Sclerosing Panencephalitis by a Simple Spinal Fluid Gel Precipitation Test for Measles

PEDIATRICS ◽  
1972 ◽  
Vol 49 (1) ◽  
pp. 133-136
Author(s):  
Dale E. Dietzman ◽  
Luiz Horta-Barbosa ◽  
Helen M. Krebs ◽  
David L. Madden ◽  
David A. Fuccillo ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Hemagglutination Inhibition ◽  
Measles Virus ◽  
Complement Fixation ◽  
Subacute Sclerosing Panencephalitis ◽  
Double Diffusion ◽  
Virus Antigen ◽  
Spinal Fluid ◽  
Reliable Procedure ◽  
Precipitation Test

A double-diffusion gel precipitation test is described which provides an easy, rapid, and reliable procedure for assistance in the diagnosis of subacute sclerosing penencephalitis by detecting measles antibody in concentrated cerebrospinal fluid. The test is based on the precipitation of rubeola antibodies with a high titered SSPE measles-virus antigen. The sensitivity of the test is comparable to the sensitivity of rubeola complement-fixation and hemagglutination-inhibition determinations on unconcentrated spiral fluid. The method could be available to hospitals or institutions if the antigen were prepared commercially or by a national center.

scholarly journals Subacute Sclerosing Panencephalitis

2019 ◽  
Vol 37 (4) ◽  
pp. 205-208
Author(s):  
Gobinda Chandra Banik ◽  
Sakib Aman ◽  
Farhana Sultana ◽  
Syed Mohammad Arif
Keyword(s):  
Cerebrospinal Fluid ◽  
Virus Infection ◽  
Antibody Titer ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Abnormal Behavior ◽  
Short History ◽  
Altered Consciousness ◽  
History Of ◽  
Metachromatic Leucodystrophy

  Subacute sclerosing panencephalitis (SSPE) is chronic progressive encephalitis of childhood and young adoloscent due to persistent measles virus infection. This case illustrates a 14 year old girl presented with short history of intellectual decline, abnormal behavior, myoclonus and altered consciousness with suggestive neuroimaging mimicking metachromatic leucodystrophy. Subsequently she was diagnosed to be a case of Subacute sclerosing panencephalitis (SSPE) on the basis of Electroencephalography (EEG) and Cerebrospinal fluid(CSF) measles antibody titer. J Bangladesh Coll Phys Surg 2019; 37(4): 205-208

Stimulation of lymphocytes from subacute sclerosing panencephalitis patients by defined measles virus antigens

1980 ◽  
Vol 51 (2) ◽  
pp. 201-214 ◽  
Author(s):  
Jorma Ilonen ◽  
Mauri Reunanen ◽  
Elja Herva ◽  
Barry Ziola ◽  
Aimo Salmi
Keyword(s):  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Virus Antigens ◽  
Stimulation Of

scholarly journals High incidence of subacute sclerosing panencephalitis in South India

1990 ◽  
Vol 104 (1) ◽  
pp. 151-156 ◽  
Author(s):  
V. Saha ◽  
T. Jacob John ◽  
P. Mukundan ◽  
C. Gnanamuthu ◽  
S. Prabhakar ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Antibody Titre ◽  
Clinical Diagnosis ◽  
Geographic Distribution ◽  
Measles Virus ◽  
South India ◽  
Subacute Sclerosing Panencephalitis ◽  
Age At Onset ◽  
Laboratory Diagnosis ◽  
High Incidence

SUMMARYDuring 19837 a clinical diagnosis of subacute sclerosing panencephalitis (SSPE) was confirmed by the detection of measles virus haemagglutination inhibiting antibody in the cerebrospinal fluid (CSF) in 81 subjects resident in Tamilnadu. The antibody titre (reciprocol of the endpoint dilution) in the CSF ranged from 2 to 32 and in the sera from 8 to 2048. The CSF: serum ratios of titres were 1:41:64 in 80 cases and 1:128 in one case. The median age at onset of SSPE was 10 years and 97% of cases were diagnosed at stage 2 and beyond. Based on the geographic distribution of 72 cases in an estimated population of 84 million, the annual incidence of SSPE was calculated to be 214 per million population, or 43 cases per million children below 20 years. Assuming that only 10% of all cases would have reached the level of laboratory diagnosis, the incidence may be as high as 21 cases per million population.

scholarly journals Subacute Sclerosing Panencephalitis in a Toddler: Changing Epidemiological Trends

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Roosy Aulakh ◽  
Abhimanyu Tiwari
Keyword(s):  
Cerebrospinal Fluid ◽  
Virus Infection ◽  
Clinical Features ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Latency Period ◽  
Slow Virus ◽  
History Of ◽  
Antibody Titers ◽  
Epidemiological Trends

Subacute sclerosing panencephalitis (SSPE) is a devastating “slow virus” brain disease resulting from persistent measles virus infection of neurons. The age at presentation is usually 8 to 11 years with onset usually occurring 2–10 years after measles infection. We report a 2-and-half-year-old boy who presented with progressively increasing myoclonic jerks and subtle cognitive decline. He was diagnosed as a case of SSPE based on clinical features, typical electroencephalographic finding, and elevated cerebrospinal fluid/serum measles antibody titers. He had measles 4 months prior to onset of symptoms. This case along with review of recently published reports suggests progressively decreasing latency period between measles infection and onset of symptoms observed in cases with SSPE. Clinical implication would mean investigating for SSPE even in infants or toddlers with compatible clinical features and recent history of measles infection.

Visualization of Defective Measles Virus Particles in Cerebrospinal Fluid in Subacute Sclerosing Panencephalitis

1987 ◽  
Vol 156 (6) ◽  
pp. 928-933 ◽  
Author(s):  
J. Andersson ◽  
A. Ehrnst ◽  
P. H. Larsson ◽  
K.- O. Hedlund ◽  
E. Norrby ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Virus Particles
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