The relationship between measles virus-specific antibodies and oligoclonal IgG in the cerebrospinal fluid (CSF) in patients with subacute sclerosing panencephalitis (SSPE) and multiple sclerosis (MS)

The article presents the literature review and our experience in early diagnosis of multiple sclerosis based on the updated McDonald criteria of 2017. The study included 256 patients with clinic symptoms of probable idiopathic infl ammatory demyelinating disease, including rare and atypical forms of demyelination. As a result of the study the sensitivity and specifi city of the determination of oligoclonal immunoglobulin G in the population of Rostov-on-Don was described for the fi rst time, including dependence of the duration of the disease. The relationship of clinical and MRI features of the fi rst attack of the disease with the probability of determining oligoclonal IgG in the cerebrospinal fl uid is refl ected

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Diagnosis of Subacute Sclerosing Panencephalitis by a Simple Spinal Fluid Gel Precipitation Test for Measles

PEDIATRICS ◽

10.1542/peds.49.1.133 ◽

1972 ◽

Vol 49 (1) ◽

pp. 133-136

Author(s):

Dale E. Dietzman ◽

Luiz Horta-Barbosa ◽

Helen M. Krebs ◽

David L. Madden ◽

David A. Fuccillo ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Hemagglutination Inhibition ◽

Measles Virus ◽

Complement Fixation ◽

Subacute Sclerosing Panencephalitis ◽

Double Diffusion ◽

Virus Antigen ◽

Spinal Fluid ◽

Reliable Procedure ◽

Precipitation Test

A double-diffusion gel precipitation test is described which provides an easy, rapid, and reliable procedure for assistance in the diagnosis of subacute sclerosing penencephalitis by detecting measles antibody in concentrated cerebrospinal fluid. The test is based on the precipitation of rubeola antibodies with a high titered SSPE measles-virus antigen. The sensitivity of the test is comparable to the sensitivity of rubeola complement-fixation and hemagglutination-inhibition determinations on unconcentrated spiral fluid. The method could be available to hospitals or institutions if the antigen were prepared commercially or by a national center.

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Oligoclonal IgG bands in the cerebrospinal fluid of portuguese patients with multiple sclerosis: negative results indicate benign disease

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2005000300001 ◽

2005 ◽

Vol 63 (2b) ◽

pp. 375-379 ◽

Cited By ~ 11

Author(s):

Maria José Sá ◽

Lucinda Sequeira ◽

Maria Edite Rio ◽

Edward J. Thompson

Keyword(s):

Multiple Sclerosis ◽

Cerebrospinal Fluid ◽

Benign Disease ◽

Serum Samples ◽

Negative Results ◽

Significant Difference ◽

Relapsing Remitting ◽

The Mean ◽

Oligoclonal Igg ◽

Oligoclonal Igg Bands

We assessed the frequency of cerebrospinal fluid (CSF) restricted oligoclonal IgG bands (IgG-OCB) in Portuguese multiple sclerosis (MS) patients and its relationship with outcome. Paired CSF/serum samples of 406 patients with neurological disorders were submitted to isoelectric focusing with immunodetection of IgG. Ninety-two patients had definite MS; non-MS cases were assembled in groups inflammatory/infectious diseases (ID, n=141) and other/controls (OD, n=173). We found in the MS group: mean duration, 38.9 months; clinically isolated syndromes, 24%; relapsing/remitting course (RR), 65%; in RR patients the mean EDSS was 2.1 and the mean index of progression was 0.31. Positive patterns significantly predominated in MS (82.6%; ID, 40.4%; OD, 3.5%). The sensitivity and the specificity of positive IgG-OCB for MS diagnosis was 82.6% and 79.9%, respectively. The sole statistically significant difference in the MS group was the lower progression index observed in negative cases. We conclude that the frequency of positive IgG-OCB patterns in our MS patients fits most values reported in the literature, and that negative results indicate benign disease.

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Subacute Sclerosing Panencephalitis

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v37i4.43352 ◽

2019 ◽

Vol 37 (4) ◽

pp. 205-208

Author(s):

Gobinda Chandra Banik ◽

Sakib Aman ◽

Farhana Sultana ◽

Syed Mohammad Arif

Keyword(s):

Cerebrospinal Fluid ◽

Virus Infection ◽

Antibody Titer ◽

Measles Virus ◽

Subacute Sclerosing Panencephalitis ◽

Abnormal Behavior ◽

Short History ◽

Altered Consciousness ◽

History Of ◽

Metachromatic Leucodystrophy

Subacute sclerosing panencephalitis (SSPE) is chronic progressive encephalitis of childhood and young adoloscent due to persistent measles virus infection. This case illustrates a 14 year old girl presented with short history of intellectual decline, abnormal behavior, myoclonus and altered consciousness with suggestive neuroimaging mimicking metachromatic leucodystrophy. Subsequently she was diagnosed to be a case of Subacute sclerosing panencephalitis (SSPE) on the basis of Electroencephalography (EEG) and Cerebrospinal fluid(CSF) measles antibody titer. J Bangladesh Coll Phys Surg 2019; 37(4): 205-208

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