Association of tnf gene polymorphisms with MS susceptibility and severity in Russian ethnic group

1995 ◽  
Vol 56-63 ◽  
pp. 10-10
Author(s):  
E.I. Gusev ◽  
M.A. Sudomoina ◽  
A.N. Boiko ◽  
T.L. Deomina ◽  
L.P. Alekseev ◽  
...  
Keyword(s):  
Ethnic Group ◽  
Gene Polymorphisms ◽  
Tnf Gene

Relative risk for cardiovascular morbidity in hemodialysis patients regarding gene polymorphism for IL-10, IL-6, and TNF

2016 ◽  
Vol 94 (10) ◽  
pp. 1106-1109 ◽  
Author(s):  
J. Tosic Dragovic ◽  
J. Popovic ◽  
P. Djuric ◽  
A. Jankovic ◽  
A. Bulatovic ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Cerebrovascular Accident ◽  
Gene Polymorphisms ◽  
Cardiovascular Events ◽  
Medical Center ◽  
Hemodialysis Patients ◽  
Left Ventricular ◽  
Cardiovascular Morbidity ◽  
Number Of Patients ◽  
Tnf Gene

Uremia-related inflammation is prone to be a key factor to explain high cardiovascular morbidity in hemodialysis patients. Genetic susceptibility may be of importance, including IL-10, IL-6, and TNF. The aim was to analyze IL-10, IL-6, and TNF gene polymorphisms in a group of hemodialysis patients and to correlate the findings with cardiovascular morbidity. This study included 169 patients on regular hemodialysis at Zvezdara University Medical Center. Gene polymorphisms for IL-10, IL-6 and TNF were determined using PCR. These findings were correlated with the cardiovascular morbidity data from patient histories. Heterozygots for IL-10 gene showed significantly lower incidence of cardiovascular events (p = 0.05) and twice lower risk for development of myocardial infarction, but experienced twice higher risk for left ventricular hypertrophy. Regarding TNF gene polymorphism, patients with A allele had 1.5-fold higher risk for cerebrovascular accident and cardiovascular events and 2-fold higher risk for hypertension and peripheral vascular disease. Patients with G allele of IL-6 gene experienced 1.5-fold higher risks for cerebrovascular accident. We need studies with larger number of patients for definitive conclusion about the influence of gene polymorphisms on cardiovascular morbidity in hemodialysis patients and its importance in everyday clinical practice.

Association of IL-1?, IL-1ra, and TNF-? gene polymorphisms in childhood nephrotic syndrome

2004 ◽  
Vol 19 (3) ◽  
pp. 295-299 ◽  
Author(s):  
Sung-Do Kim ◽  
Jae-Man Park ◽  
Il-Soo Kim ◽  
Kang-Duk Choi ◽  
Byung-Cheol Lee ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gene Polymorphisms ◽  
Childhood Nephrotic Syndrome ◽  
Tnf Gene

Relevance of IL-1 and TNF gene polymorphisms on interleukin-1β and tumor necrosis factor-α gastric mucosal production

2009 ◽  
Vol 70 (11) ◽  
pp. 935-945 ◽  
Author(s):  
María A. García-González ◽  
María A. Pérez Aísa ◽  
Mark Strunk ◽  
Rafael Benito ◽  
Elena Piazuelo ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Gene Polymorphisms ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 1Β ◽  
Tnf Gene ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals IL1 and TNF gene polymorphisms in patients with juvenile idiopathic arthritis treated with TNF inhibitors

2007 ◽  
Vol 66 (7) ◽  
pp. 900-904 ◽  
Author(s):  
R. Cimaz ◽  
M.-A. Cazalis ◽  
C. Reynaud ◽  
V. Gerloni ◽  
F. Zulian ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Gene Polymorphisms ◽  
Tnf Inhibitors ◽  
Tnf Gene

scholarly journals Tumor necrosis factor gene polymorphisms are associated with silicosis: a systemic review and meta-analysis

2019 ◽  
Vol 39 (2) ◽  
Author(s):  
Min Zhang ◽  
Ling-Long Peng ◽  
Xue-Lei Ji ◽  
Hai-Bing Yang ◽  
Ri-Sheng Zha ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Gene Polymorphisms ◽  
Tumor Necrosis ◽  
Literature Search ◽  
Meta Analysis ◽  
Asian Population ◽  
Systemic Review ◽  
Tnf Gene ◽  
Strength Of Association ◽  
Necrosis Factor

Abstract Studies investigating association between tumor necrosis factor (TNF) gene polymorphisms and silicosis susceptibility report conflicting results. The aim of this meta-analysis was to assess association between TNF gene polymorphisms and silicosis susceptibility. A systematic literature search was conducted to find relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of association. Finally, a total of 12 articles, involving 1990 silicosis patients and 1898 healthy controls were included in the meta-analysis. Overall, meta-analysis revealed a significant association between the TNF −308A allele and silicosis (OR = 1.348, 95%CI = 1.156–1.570, P<0.001). A significant association of AA+AG genotype of the TNF −308 A/G polymorphism with susceptibility to silicosis was also found (OR = 1.466, 95%CI = 1.226–1.753, P<0.001). After stratification by ethnicity, significant associations were detected under the genetic models (A allele and AA+AG genotype) for TNF −308A/G polymorphisms in the Asian population (P<0.05). Similarly, meta-analysis of the TNF −238A/G polymorphism revealed the same pattern as that shown by meta-analysis of TNF −308A/G. The meta-analysis suggests that the TNF −308A/G and −238A/G polymorphisms are associated with susceptibility to silicosis, especially in Asians.

scholarly journals The Frequencies of Allele Distribution of CYP2C9 and CYP2C19 Gene Polymorphisms in Healthy Papuan Population, Indonesia

2021 ◽  
Vol 20 (3) ◽  
Author(s):  
Syahrul Tuba ◽  
Zullies Ikawati ◽  
Mustofa
Keyword(s):  
Ethnic Group ◽  
Gene Polymorphisms ◽  
Fragment Length Polymorphism ◽  
Polymorphism Analysis ◽  
Allele Distribution ◽  
Pcr Rflp ◽  
Cyp2c19 Gene ◽  
Hardy Weinberg Equilibrium ◽  
Polymorphism Rate ◽  
Polymerase Chain

This study's objective was to determine the distribution of allele frequencies of CYP2C9 and CYP2C19 gene polymorphisms among the Papuan population, known as the second-largest ethnic group in Indonesia. According to recent research, there is a decrease in CYP2C9 and CYP2C19 produced by humans globally, including in Indonesia. These gene polymorphisms aid in the transmission of various endogenous and exogenous drugs in the human body. Material and Methods: A sum of 99 subjects, comprising 73 male and 26 female subjects aged 20-30 years, were used for this research. PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis using AvaII, NsiI, and SfaNI enzymes tested for the genotypes CYP2C9 and CYP2C19 administered. The distribution of genotypes was calculated in the population (P<0.05) using the Hardy-Weinberg equilibrium. The Faculty of Medicine Gadjah Mada University's Medical and Health Research Ethics Committee (MHREC) accepted this research with written consent. The results revealed that in Papua subjects, CYP2C9*2 (rs1799853) and CYP2C19*17 (rs12248560) alleles were absent while in 17 percent of the population CYP2C9*3 (rs1057910) allele frequency was. In conclusion, CYP2C9*3 has the highest polymorphism rate in Indonesia, with the absence of CYP2C9*2 and CYP2C19*17. Therefore, genetic drift can occur within this ethnic group. Keywords: Genotyping; Papuan ethnic; Pharmacogenetics; Polymorphisms

Association of CTLA4 and TNF gene polymorphisms with endocrine ophthalmopathy in ethnic Russian patients with Graves’ disease

2015 ◽  
Vol 87 (10) ◽  
pp. 67 ◽  
Author(s):  
N. S. Martirosian ◽  
A. M. Burdennyi ◽  
L. V. Trukhina ◽  
O. G. Panteleeva ◽  
S. V. Saakyan ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Graves Disease ◽  
Endocrine Ophthalmopathy ◽  
Tnf Gene
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