122 Antiviral activity of triciribine and triciribine monophosphate against human herpesvirus type 6

1994 ◽  
Vol 23 ◽  
pp. 100
Keyword(s):  
Antiviral Activity ◽  
Human Herpesvirus ◽  
Herpesvirus Type ◽  
Human Herpesvirus Type

scholarly journals Mechanism of the Antiviral Activity of New Aurintricarboxylic Acid Analogues

1996 ◽  
Vol 7 (3) ◽  
pp. 142-152 ◽  
Author(s):  
D. Reymen ◽  
M. Witvrouw ◽  
J. A. Esté ◽  
J. Neyts ◽  
D. Schols ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Parent Compound ◽  
Flow Cytometric Analysis ◽  
Human Herpesvirus ◽  
Enveloped Viruses ◽  
Herpesvirus Type ◽  
Aurintricarboxylic Acid ◽  
Dna And Rna ◽  
Human Herpesvirus Type ◽  
Hiv 1

Various new aurintricarboxylic acid (ATA) polymer analogues have been evaluated for their antiviral activity against a wide array of DNA and RNA viruses, and their mechanism of action against human cytomegalovirus (HCMV) and human immunodeficiency virus type 1 (HIV-1). Most of the polymers exhibited marked antiviral activity against a variety of enveloped viruses, but not against non-enveloped viruses. The ATA polymers displayed the most pronounced activity against HIV-1, HCMV and human herpesvirus type 6 (HHV-6). Their action against HCMV and HIV could be ascribed to inhibition of the initial attachment of virus particles to the cells. Using radiolabelled virus, we proved that the polymers inhibit the binding of HCMV to HEL fibroblasts. By flow cytometric analysis, we demonstrated that these new polymers interfere with (i) the binding of OKT4A monoclonal antibody (mAb) to the cellular CD4 receptor, (ii) the binding of anti-gp120 mAb to HIV-1 glycoprotein (gp) 120, and (iii) the adsorption of HIV-1 virions and recombinant HIV-1gp120 (rgp120) to MT-4 cells. The presence of a salicylic acid substituent on the central bridging carbon in the parent compound ATA seems to play an important role in the anti-HIV activity of these ATA related polymer analogues.

Increased prevalence of human herpesvirus type 8 (HHV-8) genome among blood donors from North-Western Argentina

2016 ◽  
Vol 89 (3) ◽  
pp. 518-527 ◽  
Author(s):  
María Laura Hulaniuk ◽  
Oscar Torres ◽  
Sonia Bartoli ◽  
Lisandro Fortuny ◽  
Leandro Burgos Pratx ◽  
...  
Keyword(s):  
Blood Donors ◽  
Human Herpesvirus ◽  
Herpesvirus Type ◽  
Human Herpesvirus Type ◽  
North Western

scholarly journals Immunohistochemical detection of the latent nuclear antigen-1 of the human herpesvirus type 8 to differentiate cutaneous epidemic Kaposi sarcoma and its histological simulators

2013 ◽  
Vol 88 (2) ◽  
pp. 243-246 ◽  
Author(s):  
Patricia Fonseca Pereira ◽  
Tullia Cuzzi ◽  
Maria Clara Gutierrez Galhardo
Keyword(s):  
Kaposi's Sarcoma ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Nuclear Antigen ◽  
Immunohistochemical Detection ◽  
Herpesvirus Type ◽  
Human Herpesvirus Type ◽  
Skin Biopsies ◽  
Latent Nuclear Antigen

Kaposi's sarcoma is the most common neoplasia diagnosed in AIDS patients and the expression of the human herpesvirus-8 (HHV-8) latent nuclear antigen-1 has been useful for its histological diagnosis. The aim of this study is to confirm that immunohistochemistry is a valuable tool for differentiating KS from its simulators in skin biopsies of HIV patients. Immunohistochemical and histological analyses were performed in 49 Kaposi's sarcoma skin biopsies and 60 of its histological simulators. Positivity was present in the 49 Kaposi's sarcoma skin biopsies and no staining was observed in the 60 simulators analyzed, resulting in sensibility and specificity of 100%. HHV-8 immunohistochemical detection is an effective tool for diagnosing Kaposi's sarcoma, especially in early lesions in which neoplastic features are not evident. It also contributes to its histological differential diagnosis.

scholarly journals Clinical Aspects of Bacterial Corneal Ulcer Prolonged Course, the Role of Herpes Viruses in Its Pathogenesis, Treatment

2019 ◽  
Vol 16 (1S) ◽  
pp. 40-44
Author(s):  
V. V. Neroev ◽  
L. A. Katargina ◽  
L. A. Kovaleva ◽  
G. I. Krichevskaya ◽  
N. V. Balatskaya
Keyword(s):  
Corneal Ulcer ◽  
Human Herpesvirus ◽  
Clinical Aspects ◽  
Herpesvirus Type ◽  
Corneal Ulcers ◽  
Barr Virus ◽  
Human Herpesvirus Type ◽  
Epstein Barr ◽  
Simplex Virus

Purpose: to study the role of human herpesviruses (HHV) in the pathogenesis of prolonged bacterial corneal ulcers. Patients and methods. 117 patients with bacterial corneal ulcer were examined. Two groups were identified: a favorable course-with duration of bacterial corneal ulcer epithelialization for 17 days (62 people) and a prolonged course with a persistent ulcer more than 17 days (55 people). Blood samples (n = 117) and scrapes from corneal ulcer (n = 117) were investigated in polymerase chain reaction (PCR) for the presence of deoxyribonucleic acid (DNA) of Herpes simplex virus (HSV1, 2), Epstein-Barr virus (EBV), Human herpesvirus type 6, 7 (HHV-6, HSV-7). Results. The HSV1, 2 and EBV genomes were detected in the cornea significantly more often in BCU of prolonged course compared with a favorable course (HSV1, 2 p = 0.012; EBV p = 0.012), and HHV-6 was detected not only in the cornea (p = 0.000), but also and in blood (p = 0.007). In patients with HHV DNA in corneal scarps and/or blood, after resorption of purulent infiltrate, corneal epithelialization was absent, and the use of antiherpetic drugs allowed to reduce the completion time of BCU epithelialization. Conclusion. The role of HHV-6, EBV, HSV 1, 2 in the pathogenesis of bacterial corneal ulcer of protracted course was revealed. The expediency of examination of patients with bacterial corneal ulcer on HHV is shown, a method of treatment is proposed, including antiherpetic therapy, which makes it possible to prevent the development of a protracted course.

Kutapressin Inhibits In Vitro Infection of Human Herpesvirus Type 6

1994 ◽  
Vol 18 (Supplement_1) ◽  
pp. S113-S113
Author(s):  
D. V. Ablashi ◽  
Z. Berneman ◽  
C. Lawyer ◽  
A. Komaroff
Keyword(s):  
Human Herpesvirus ◽  
Herpesvirus Type ◽  
Human Herpesvirus Type

scholarly journals Human herpesvirus type 6 reactivation after haematopoietic stem cell transplantation

2008 ◽  
Vol 43 (4) ◽  
pp. 361-366 ◽  
Author(s):  
P.J. de Pagter ◽  
Rob Schuurman ◽  
Ellen Meijer ◽  
Debbie van Baarle ◽  
E.A.M. Sanders ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Haematopoietic Stem Cell Transplantation ◽  
Human Herpesvirus ◽  
Haematopoietic Stem Cell ◽  
Herpesvirus Type ◽  
Human Herpesvirus Type
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