Mechanism of the Antiviral Activity of New Aurintricarboxylic Acid Analogues

Various new aurintricarboxylic acid (ATA) polymer analogues have been evaluated for their antiviral activity against a wide array of DNA and RNA viruses, and their mechanism of action against human cytomegalovirus (HCMV) and human immunodeficiency virus type 1 (HIV-1). Most of the polymers exhibited marked antiviral activity against a variety of enveloped viruses, but not against non-enveloped viruses. The ATA polymers displayed the most pronounced activity against HIV-1, HCMV and human herpesvirus type 6 (HHV-6). Their action against HCMV and HIV could be ascribed to inhibition of the initial attachment of virus particles to the cells. Using radiolabelled virus, we proved that the polymers inhibit the binding of HCMV to HEL fibroblasts. By flow cytometric analysis, we demonstrated that these new polymers interfere with (i) the binding of OKT4A monoclonal antibody (mAb) to the cellular CD4 receptor, (ii) the binding of anti-gp120 mAb to HIV-1 glycoprotein (gp) 120, and (iii) the adsorption of HIV-1 virions and recombinant HIV-1gp120 (rgp120) to MT-4 cells. The presence of a salicylic acid substituent on the central bridging carbon in the parent compound ATA seems to play an important role in the anti-HIV activity of these ATA related polymer analogues.

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Psychosocial modulation of antibody to Epstein-Barr viral capsid antigen and human herpesvirus type-6 in HIV-1-infected and at-risk gay men.

Psychosomatic Medicine ◽

10.1097/00006842-199205000-00011 ◽

1992 ◽

Vol 54 (3) ◽

pp. 354-371 ◽

Cited By ~ 75

Author(s):

B A Esterling ◽

M H Antoni ◽

N Schneiderman ◽

C S Carver ◽

A LaPerriere ◽

...

Keyword(s):

At Risk ◽

Gay Men ◽

Human Herpesvirus ◽

Viral Capsid ◽

Viral Capsid Antigen ◽

Herpesvirus Type ◽

Human Herpesvirus Type ◽

Epstein Barr ◽

Hiv 1

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Epidemiology of human herpesvirus type 8 and parvovirus B19 infections and their association with HIV-1 among men who have sex with men and injection drug users in Taiwan

Journal of Microbiology Immunology and Infection ◽

10.1016/j.jmii.2013.01.006 ◽

2014 ◽

Vol 47 (3) ◽

pp. 233-238 ◽

Cited By ~ 6

Author(s):

Yuan-Ming Lee ◽

Shao-Yuan Chuang ◽

Sheng-Fan Wang ◽

Yu-Ting Lin ◽

Yi-Ming Arthur Chen

Keyword(s):

Injection Drug Users ◽

Drug Users ◽

Parvovirus B19 ◽

Human Herpesvirus ◽

Injection Drug ◽

Herpesvirus Type ◽

Human Herpesvirus Type ◽

Sex With Men ◽

Hiv 1

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122 Antiviral activity of triciribine and triciribine monophosphate against human herpesvirus type 6

Antiviral Research ◽

10.1016/0166-3542(94)90245-3 ◽

1994 ◽

Vol 23 ◽

pp. 100

Keyword(s):

Antiviral Activity ◽

Human Herpesvirus ◽

Herpesvirus Type ◽

Human Herpesvirus Type

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Potential of an Eco-Sustainable Probiotic-Cleaning Formulation in Reducing Infectivity of Enveloped Viruses

Viruses ◽

10.3390/v13112227 ◽

2021 ◽

Vol 13 (11) ◽

pp. 2227

Author(s):

Maria D’Accolti ◽

Irene Soffritti ◽

Francesco Bonfante ◽

Walter Ricciardi ◽

Sante Mazzacane ◽

...

Keyword(s):

Negative Impact ◽

Human Herpesvirus ◽

Influenza Viruses ◽

Antiviral Action ◽

Virus Spread ◽

Enveloped Viruses ◽

Herpesvirus Type ◽

Human Herpesvirus Type ◽

High Level

The COVID-19 pandemic has deeply influenced sanitization procedures, and high-level disinfection has been massively used to prevent SARS-CoV-2 spread, with potential negative impact on the environment and on the threat of antimicrobial resistance (AMR). Aiming to overcome these concerns, yet preserving the effectiveness of sanitization against enveloped viruses, we assessed the antiviral properties of the Probiotic Cleaning Hygiene System (PCHS), an eco-sustainable probiotic-based detergent previously proven to stably abate pathogen contamination and AMR. PCHS (diluted 1:10, 1:50 and 1:100) was tested in comparison to common disinfectants (70% ethanol and 0.5% sodium hypochlorite), in suspension and carrier tests, according with the European UNI EN 14476:2019 and UNI EN 16777:2019 standards. Human alpha- and beta-coronaviruses hCoV-229E and SARS-CoV-2, human herpesvirus type 1, human and animal influenza viruses, and vaccinia virus were included in the study. The results showed that PCHS was able to inactivate 99.99% of all tested viruses within 1-2 h of contact, both in suspension and on surface. Notably, while control disinfectants became inactive within 2 h after application, the PCHS antiviral action persisted up to 24 h post-application, suggesting that its use may effectively allow a continuous prevention of virus spread via contaminated environment, without worsening environmental pollution and AMR concern.

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