Effect of combination therapy with ribavirin and human interferon alfa on subacute sclerosing panencephalitis (SSPE) virus in hamsters

1996 ◽  
Vol 30 (1) ◽  
pp. A55
Author(s):  
Hannah R. Brown ◽  
Anthony F. Nostro ◽  
Halldor Thormar

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing disease of the CNS in children which is caused by measles virus. Ferrets immunized with measles virus prior to inoculation with the cell associated, syncytiogenic D.R. strain of SSPE virus exhibit characteristics very similar to the human disease. Measles virus nucleocapsids are present, high measles antibody titers are found in the sera and inflammatory lesions are prominent in the brains. Measles virus specific immunoglobulin G (IgG) is present in the brain,and IgG/ albumin ratios indicate that the antibodies are synthesized within the CNS.


Digestion ◽  
2003 ◽  
Vol 68 (1) ◽  
pp. 1-4 ◽  
Author(s):  
U. Schiemann ◽  
J. Glas ◽  
P. Török ◽  
C. Simperl ◽  
K. Martin ◽  
...  

2012 ◽  
Vol 27 (2) ◽  
pp. 111
Author(s):  
Dong Hyun Park ◽  
Sang Uk Lee ◽  
Jin Seok Yu ◽  
Jun Seop Lee ◽  
Hye Jung Kwon

2003 ◽  
Vol 124 (4) ◽  
pp. A383
Author(s):  
Ravi Ravinuthala ◽  
Vosudesh Pai ◽  
Dilip Moonka ◽  
Kimberly Brown

1990 ◽  
Vol 11 ◽  
pp. S163
Author(s):  
M Piazza ◽  
V Guadagnino ◽  
L Picciotto ◽  
G Borgia ◽  
R Orlando ◽  
...  

1996 ◽  
Vol 1 (6) ◽  
pp. 372-375 ◽  
Author(s):  
H Nyland ◽  
K-M Myhr ◽  
F Lillås ◽  
AI Smievoll ◽  
T Riise ◽  
...  

A multicentre, randomised, double-blind, placebo controlled study to evaluate the efficacy and safety of 4.5 and 9.0 MIU recombinant human interferon alfa-2a (Rof eron-A™) given thrice weekly in patients with relapsing-remittent multiple sclerosis is described. The patients are treated for 6 months followed by a 6 months drug-free period. The primary objective is to determine new disease activity analysed by monthly MRI with gadodiamide (GdDTPA-BMA, Omniscan™). The study is conducted at eight centers in Norway and is completed in January 1996.


JAMA ◽  
1989 ◽  
Vol 262 (19) ◽  
pp. 2684b-2684
Author(s):  
J. T. Coyle

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