Age-related changes in learning and memory and cholinergic neuronal function in senescence accelerated mice (SAM)

1995 ◽  
Vol 72 (1-2) ◽  
pp. 49-55 ◽  
Author(s):  
Atsumi Nitta ◽  
Kazumasa Naruhashi ◽  
Masayuki Umemura ◽  
Takaaki Hasegawa ◽  
Shoei Furukawa ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Neuronal Function ◽  
Age Related ◽  
Senescence Accelerated Mice ◽  
Age Related Changes

scholarly journals Effects of Dietary DNA from Chum Salmon Milt on Memory and Age-related Changes in Senescence-accelerated Mice

2008 ◽  
Vol 55 (10) ◽  
pp. 461-467 ◽  
Author(s):  
Makoto Mitarai ◽  
Tsu-Fang Hsu ◽  
Ming-Fu Wang ◽  
Hiroshi Hirahara ◽  
Haruchika Sekido ◽  
...  
Keyword(s):  
Chum Salmon ◽  
Age Related ◽  
Senescence Accelerated Mice ◽  
Dietary Dna ◽  
Age Related Changes

scholarly journals Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function

2015 ◽  
Vol 594 (16) ◽  
pp. 4565-4579 ◽  
Author(s):  
Junji Egawa ◽  
Matthew L. Pearn ◽  
Brian P. Lemkuil ◽  
Piyush M. Patel ◽  
Brian P. Head
Keyword(s):  
Lipid Rafts ◽  
Membrane Lipids ◽  
Membrane Lipid ◽  
Neuronal Function ◽  
Age Related ◽  
Age Related Changes

scholarly journals OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Ryan J Bevan ◽  
Pete A Williams ◽  
Caroline T Waters ◽  
Rebecca Thirgood ◽  
Amanda Mui ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Memory Performance ◽  
Memory Deficits ◽  
Metabolic Dysfunction ◽  
Neuronal Function ◽  
Synaptic Density ◽  
Ca1 Neurons ◽  
Mitochondrial Homeostasis ◽  
Age Related ◽  
Spatial Novelty

Abstract A healthy mitochondrial network is essential for the maintenance of neuronal synaptic integrity. Mitochondrial and metabolic dysfunction contributes to the pathogenesis of many neurodegenerative diseases including dementia. OPA1 is the master regulator of mitochondrial fusion and fission and is likely to play an important role during neurodegenerative events. To explore this, we quantified hippocampal dendritic and synaptic integrity and the learning and memory performance of aged Opa1 haploinsufficient mice carrying the Opa1Q285X mutation (B6; C3-Opa1Q285STOP; Opa1+/−). We demonstrate that heterozygous loss of Opa1 results in premature age-related loss of spines in hippocampal pyramidal CA1 neurons and a reduction in synaptic density in the hippocampus. This loss is associated with subtle memory deficits in both spatial novelty and object recognition. We hypothesize that metabolic failure to maintain normal neuronal activity at the level of a single spine leads to premature age-related memory deficits. These results highlight the importance of mitochondrial homeostasis for maintenance of neuronal function during ageing.

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