Age-related changes in blood and liver lipids of male wistar rats

1993 ◽  
Vol 16 (3) ◽  
pp. 249-262 ◽  
Author(s):  
Alfredo Cantafora ◽  
Roberta Masella ◽  
Elena Pignatelli ◽  
Roberto Verna
Keyword(s):  
Wistar Rats ◽  
Liver Lipids ◽  
Age Related ◽  
Male Wistar Rats ◽  
Age Related Changes

Age-Related Changes in Lipid Secretion of Perfused Livers from Male Wistar Rats Donors

1996 ◽  
Vol 119 (2) ◽  
pp. 240-245 ◽  
Author(s):  
E. Bravo ◽  
R. Rivabene ◽  
G. Bruscalupi ◽  
A. Calcabrini ◽  
G. Arancia ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Lipid Secretion ◽  
Age Related ◽  
Male Wistar Rats ◽  
Age Related Changes

Renal Cortical Slices: An In Vitro Model for Kidney Metabolism and Toxicity

1992 ◽  
Vol 20 (1) ◽  
pp. 71-76
Author(s):  
Andrea Trevisan ◽  
Stefano Maso ◽  
Paola Meneghetti
Keyword(s):  
Wistar Rats ◽  
Reduced Glutathione ◽  
Organic Anion ◽  
Cortical Slice ◽  
Lactate Dehydrogenase Release ◽  
Age Related ◽  
Renal Cortical Slice ◽  
Male Wistar Rats ◽  
Vitro Model

The in vitro renal cortical slice model was used to study: 1) the effects on the kidney of some haloalkanes and haloalkenes using 3-month-old male Wistar rats; 2) influence of age and sex on renal cortical slice indices in non-treated rats; and 3) effects of 1,2-dichloropropane on the slices after pretreatment of 3-month-old male Wistar rats with DL-butathionine-[S,R]-sulphoximine. The most nephrotoxic chemical used was 1,3-dichloropropene, which caused a total depletion in the levels of reduced glutathione, a high peroxidation of lipid (about three thousand-fold with respect to control), a significant release of tubular enzymes into the medium, and loss of organic anion ( p-aminohippurate) accumulation. All the chemicals affected the cytosol more than the brush border. The most remarkable age-related differences in the untreated slices were the progressive decrease of reduced glutathione (p<0.05 from three months of age), and an increase in lactate dehydrogenase release into the medium (p<0.05 from six months of age). By contrast, sex differences were slight. The ‘treatment with 1,2-dichloropropane of slices prepared from rats pretreated with DL-butathionine-[S,R]-sulphoximine significantly increased the depletion of glutathione content (p<0.05) and malondialdehyde release in the medium (p<0.001) caused by the solvent alone.

Age-related variations in plasma and liver lipids of Yoshida rats: a comparison with Wistar rats

1995 ◽  
Vol 111 (2) ◽  
pp. 319-327 ◽  
Author(s):  
R. Masella ◽  
E. Pignatelli ◽  
T. Marinelli ◽  
D. Modesti ◽  
R. Verna ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Liver Lipids ◽  
Age Related ◽  
Plasma And Liver Lipids

scholarly journals Comparative studies on the hypercholesterolaemia induced by excess dietary tyrosine or polychlorinated biphenyls in rats

1986 ◽  
Vol 56 (2) ◽  
pp. 509-517 ◽  
Author(s):  
Sahoshi Nagaoka ◽  
Mitsuhiro Kato ◽  
Yoritaka Aoyama ◽  
Akira Yoshida†
Keyword(s):  
Ascorbic Acid ◽  
Polychlorinated Biphenyls ◽  
Comparative Studies ◽  
Wistar Rats ◽  
Serum Levels ◽  
Liver Lipids ◽  
Male Wistar Rats

1. The effects of dietary polychlorinated biphenyls (PCB) and excess tyrosine on serum and liver lipids, urinary ascorbic acid and catecholamines were compared in male Wistar rats.2. Serum levels of cholesterol, urinary ascorbic acid, norepinephrine, epinephrine, dopamine and histamine were significantly increased in rats given either PCB or excess tyrosine.3. The hypercholesterolaemia induced by PCB or excess tyrosine was blocked by the adrenergic α-blocker, phenoxybenzamine.4. The present results suggest causal interrelations between the hypercholesterolaemia induced by dietary PCB or excess tyrosine and the secretion of catecholamines.

scholarly journals Age-related Individual Behavioural Characteristics of Adult Wistar Rats

2021 ◽  
Author(s):  
Sergey Sudakov ◽  
Elena Alekseeva ◽  
Galina Nazarova ◽  
Valentina Bashkatova
Keyword(s):  
Motor Activity ◽  
Wistar Rats ◽  
Individual Characteristics ◽  
Female Rats ◽  
Related Individual ◽  
Male And Female Rats ◽  
Age Related ◽  
Behavioural Characteristics ◽  
Plus Maze ◽  
Age Related Changes

The aim of this work was to study age-related changes in the behaviour of adult Wistar rats using the open field (OF) and elevated plus maze (EPM) tests. Behavioural changes related to motor activity and anxiety were of particular interest. Results showed that as male and female rats progressed from 2 to 5 months of age there was a decrease in the level of motor and exploratory activities, and an increase in the level of anxiety. Age-related changes were dependent upon initial individual characteristics of behaviour. For example, animals that demonstrated high motor activity at 2 months become significantly less active by 5 months, and animals that showed a low level of anxiety at 2 months become more anxious by 5 months. Low-activity and high-anxiety rats did not show any significant age-related changes in OF and EPM tests from 2 to 5 months of age, except for a decrease in the number of rearings in EPM. Significant individual differences in the behaviour of rats in OF and EPM tests observed at 2 months were not apparent by 5 months.

Sign in / Sign up

Export Citation Format

Share Document