Gentamycin/poly(lactic acid) blends aimed at sustained release local antibiotic therapy administered per-operatively. I. The case of gentamycin base and gentamycin sulfate in poly(dl-lactic acid) oligomers

1993 ◽  
Vol 23 (3) ◽  
pp. 209-220 ◽  
Author(s):  
J. Mauduit ◽  
N. Bukh ◽  
M. Vert
Keyword(s):  
Lactic Acid ◽  
Sustained Release ◽  
Antibiotic Therapy ◽  
Poly Lactic Acid ◽  
Local Antibiotic ◽  
Local Antibiotic Therapy

Search for algorithms for treatment of non-specific septic spondylodiscitis

2020 ◽  
pp. 65-72
Author(s):  
V. N. Obolensky ◽  
A. V. Sytnik
Keyword(s):  
Antibiotic Therapy ◽  
Negative Pressure ◽  
Spinal Column ◽  
Treatment Results ◽  
Pressure Method ◽  
Personalized Approach ◽  
Staged Treatment ◽  
Local Antibiotic ◽  
Local Antibiotic Therapy

The treatment results of 30 patients with non-specific purulent diseases of the spine were analyzed using various methods — primary or secondary stabilization of the spinal column, local negative pressure method, prolonged local antibiotic therapy method and various implants. The results were rated as «excellent» in 16 patients, «good» in 7 people, «satisfactory» in 4 cases (relapses) and 3 patients died. The results obtained indicate the need for a personalized approach to treatment tactics, the feasibility of staged treatment and the use of additional methods.

Local antibiotic therapy for endoprosthesis site infection (Literature review)

2021 ◽  
Vol 90 (4) ◽  
pp. 78-85
Author(s):  
T.A. Kilmetov ◽  
◽  
I.F. Akhtyamov ◽  
Keyword(s):  
Comparative Analysis ◽  
Literature Review ◽  
Antibiotic Therapy ◽  
Musculoskeletal System ◽  
Treatment Options ◽  
Revision Arthroplasty ◽  
Infectious Complications ◽  
Site Infection ◽  
Local Antibiotic ◽  
Local Antibiotic Therapy

Endoprosthetics of joints has firmly taken its place in a number of orthopedic interventions in the treatment of diseases of the musculoskeletal system. Unfortu-nately, with an increase in the number of operations, the number of complications that develop at various stages of treatment does not decrease. Deep infections in the area of the endoprosthesis (paraprosthetic infection) are especially difficult in treatment, since only 20% of patients, and mainly in early forms of complications, manage to save the implant. The incidence of infectious complications at the stationary stage in specialized endoprosthetics centers does not exceed 1% during primary operations, but their number, as a rule, multiplies several years after the intervention. The most common treatment option for paraprosthetic infection is staged revision arthroplasty. The authors of the review conduct a comparative analysis of the effectiveness of one- and two-stage treatment options. The latter is based on the use of bone cement spacers impregnated with antibiotics.

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