Very-high-flux research reactor concepts

1986 ◽  
Vol 249 (1) ◽  
pp. 77-90 ◽  
Author(s):  
Arne P. Olson
Keyword(s):  
Research Reactor ◽  
High Flux ◽  
Very High

scholarly journals Randomised trial on clinical performances and biocompatibility of four high-flux hemodialyzers in two mode treatments: hemodialysis vs post dilution hemodiafiltration

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Marion Morena ◽  
Caroline Creput ◽  
Mouloud Bouzernidj ◽  
Annie Rodriguez ◽  
Lotfi Chalabi ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Randomised Trial ◽  
High Flux ◽  
Β2 Microglobulin ◽  
Inflammatory Parameters ◽  
Large Size ◽  
Significant Difference ◽  
Good Biocompatibility ◽  
Very High ◽  
Solute Clearance

AbstractThis prospective multicenter randomized comparative cross-over trial aimed at evaluating the influence of hemodialysis vs post-dilution hemodiafiltration with high-flux dialyzers in solute clearance and biocompatibility profile. 32 patients were sequentially dialyzed with Leoceed-21HX, Polypure-22S+, Rexsys-27H and VIE-21A. Primary outcome was β2-microglobulin removal. Secondary outcomes were (i) extraction of other uremic solutes (ii) parameters of inflammation and nutrition and (iii) comparative quantification of perdialytic albumin losses (using total ‘TDC’ vs partial ‘PDC’ collection of dialysate). Significant increases in removal rates of β2-microglobulin (84.7 ± 0.8 vs 71.6 ± 0.8 mg/L), myoglobin (65.9 ± 1.3 vs 38.6 ± 1.3 µg/L), free immunoglobulin light chains Kappa (74.9 ± 0.8 vs 55.6 ± 0.8 mg/L), β-trace protein (54.8 ± 1.3 vs 26.8 ± 1.4 mg/L) and orosomucoid (11.0 ± 1.1 vs 6.0 ± 1.1 g/L) but not myostatin (14.8 ± 1.5 vs 13.0 ± 1.5 ng/mL) were observed in HDF compared to HD when pooling all dialyzers. Rexsys and VIE-A use in both HD and HDF subgroups was associated to a better removal of middle/large-size molecules compared to Leoceed and Polypure, except β2-microglobulin for Rexsys. Inflammatory parameters were unchanged between dialyzers without any interaction with dialysis modality. Mean dialysate albumin loss was comparable between TDC and PDC (1.855 vs 1.826 g/session for TDC and PDC respectively). In addition, a significant difference in albumin loss was observed between dialyzers with the highest value (4.5 g/session) observed using Rexsys. Use of all dialyzers was associated with good removals of the large spectrum of uremic toxins tested and good biocompatibility profiles, with an additional gain in removal performances with HDF. Larger surface area, thinner wall and resultant very high ultrafiltration coefficient of Rexsys should be taken into account in its clear performance advantages.

scholarly journals Evaluation of the efficacy of a very high permeability dialyser and comparison with another high-flux dialyser in online haemodiafiltration

2019 ◽  
Vol 13 (1) ◽  
pp. 114-115
Author(s):  
Ana María García-Prieto ◽  
Almudena Vega ◽  
Soraya Abad ◽  
Nicolás Macías ◽  
Inés Aragoncillo ◽  
...  
Keyword(s):  
High Flux ◽  
High Permeability ◽  
Very High

scholarly journals SP476EVALUATION OF THE EFFICACY OF A VERY HIGH PERMEABILITY DIALYZER AND COMPARISON WITH OTHER HIGH FLUX DIALYZER IN ONLINE HEMODIAFILTRATION

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Ana Garcia-Prieto ◽  
Almudena Vega ◽  
Soraya Abad ◽  
Nicolas Macias ◽  
Inés Aragoncillo ◽  
...  
Keyword(s):  
High Flux ◽  
High Permeability ◽  
Very High

Application of best estimate thermal hydraulic code for safety analysis of high flux research reactor

2017 ◽  
Vol 6 (2) ◽  
pp. 109-117
Author(s):  
Samiran Sengupta ◽  
Vijay K. Veluri ◽  
R. Patel ◽  
S. Mammen ◽  
S. Bhattacharya
Keyword(s):  
Research Reactor ◽  
Safety Analysis ◽  
High Flux ◽  
Best Estimate

scholarly journals High-Flux Hemodialysis and Levocarnitine in the Treatment of Severe Valproic Acid Intoxication

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
V. Temel ◽  
Müge Arikan ◽  
G. Temel
Keyword(s):  
Valproic Acid ◽  
Bone Marrow Failure ◽  
Common Finding ◽  
High Flux ◽  
Mental Function ◽  
Psychiatric Facility ◽  
Central Nervous System Depression ◽  
Severe Intoxication ◽  
Inpatient Psychiatric Facility ◽  
Very High

Valproic acid (VPA) intoxication incidence is increasing, because of the use of VPA in psychiatric disorders. The most common finding of VPA intoxication is central nervous system depression which leads to coma and respiratory depression. Pancreatitis, hyperammonemia, metabolic, and bone marrow failure (thrombocytopenia and leukopenia) have also been described. Treatment is mainly supportive. We present the case of an 18-year-old female patient, who made an attempt to autolysis with VPA. Our patient's VPA plasma level was very high (924 μg/mL), confirming that it was a severe intoxication. Our treatment including levocarnitine (50 mg/kg per day for 3 days), and high-flux hemodialysis was performed for four hours. The patient's hemodynamic status and mental function improved in conjunction with the acute reduction in VPA concentrations. Her subsequent hospital course was complicated by transient thrombocytopenia and levocarnitine induced hypophosphatemia. By day 6, the patient's laboratory values had completely normalized, and she was transferred to an inpatient psychiatric facility for continuing therapy.

scholarly journals Measurement of the 13C(n,$\gamma$) thermal cross section via neutron irradiation and AMS

2019 ◽  
Vol 55 (11) ◽  
Author(s):  
T. Wright ◽  
S. Bennett ◽  
S. Heinitz ◽  
U. Köster ◽  
R. Mills ◽  
...  
Keyword(s):  
Activation Analysis ◽  
Cross Section ◽  
Research Reactor ◽  
Gamma Ray ◽  
Beam Line ◽  
Prompt Gamma ◽  
High Flux ◽  
Accelerator Mass Spectrometer ◽  
Thermal Cross Section ◽  
Good Agreement

Abstract.Ampoules of amorphous 99.5% enriched 13C were irradiated at the PF1b neutron beam line at the high-flux ILL research reactor in order to produce 14C atoms. The precise ratio of 14C/13C was subsequently measured at the VERA Accelerator Mass Spectrometer, allowing the 13C(n,$ \gamma$γ)14C thermal cross section to be accurately determined. This is the first measurement of this cross section at sub-eV energies via this technique and the result of $ 1.52 \pm 0.07$1.52±0.07 mb for the thermal cross section is in good agreement with other recent measurements which were performed via Prompt Gamma-ray Activation Analysis.

Microchannels and Minichannels: History, Terminology, Classification and Current Research Needs

2003 ◽  
Author(s):  
Satish G. Kandlikar
Keyword(s):  
Heat Transfer ◽  
Historical Perspective ◽  
High Heat ◽  
High Flux ◽  
Research Needs ◽  
Transfer Rates ◽  
High Heat Transfer ◽  
Liver And Kidney ◽  
The Brain ◽  
Very High

Microchannels and Minichannels are found in many biological systems providing very high heat and mass transfer rates in organs such as the brain, lung, liver and kidney. Many high flux cooling applications are effectively utilizing their high heat transfer capabilities of these channels. A brief overview of the historical perspective and some of the issues that need to be addressed with microchannels and Minichannels are presented in this paper.

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