Expression of nuclear hormone receptors within the rat hippocampus: identification of novel orphan receptors

1994 ◽  
Vol 23 (3) ◽  
pp. 278-283 ◽  
Author(s):  
Sandra Peña de Ortiz ◽  
Michelle M. Cannon ◽  
Gordon A. Jamieson
Keyword(s):  
Hormone Receptors ◽  
Rat Hippocampus ◽  
Nuclear Hormone Receptors ◽  
Orphan Receptors

scholarly journals Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of Transcription

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2606
Author(s):  
Lian Jing Tao ◽  
Dong Eun Seo ◽  
Benjamin Jackson ◽  
Natalia B. Ivanova ◽  
Fabio Rinaldo Santori
Keyword(s):  
Fatty Acids ◽  
Transcription Factors ◽  
Amino Acid ◽  
Small Molecules ◽  
Hormone Receptors ◽  
Nuclear Hormone Receptors ◽  
Amino Acid Derivatives ◽  
Orphan Receptors ◽  
Caenorhabditis Elegans Genome ◽  
Over Time

Nuclear hormone receptors are a family of transcription factors regulated by small molecules derived from the endogenous metabolism or diet. There are forty-eight nuclear hormone receptors in the human genome, twenty of which are still orphans. In this review, we make a brief historical journey from the first observations by Berthold in 1849 to the era of orphan receptors that began with the sequencing of the Caenorhabditis elegans genome in 1998. We discuss the evolution of nuclear hormone receptors and the putative ancestral ligands as well as how the ligand universe has expanded over time. This leads us to define four classes of metabolites—fatty acids, terpenoids, porphyrins and amino acid derivatives—that generate all known ligands for nuclear hormone receptors. We conclude by discussing the ongoing efforts to identify new classes of ligands for orphan receptors.

scholarly journals 1F. Retinoic acid-related orphans (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Anton Jetten ◽  
Hong Soon Kang ◽  
Yukimasa Takeda
Keyword(s):  
Retinoic Acid ◽  
Hormone Receptors ◽  
Retinoic Acid Receptor ◽  
Nuclear Hormone Receptors ◽  
Endogenous Ligand ◽  
Orphan Receptors ◽  
Acid Receptor

Retinoic acid receptor-related orphan receptors (ROR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [10]) have yet to be assigned a definitive endogenous ligand, although RORα may be synthesized with a ‘captured’ agonist such as cholesterol [63, 62].

Nuclear Hormone Receptors and Adipogenesis

1998 ◽  
Vol 8 (2) ◽  
pp. 141-168 ◽  
Author(s):  
Jeffrey M. Gimble ◽  
Claudius E. Robinson ◽  
Stephen L. Clarke ◽  
Molly R. Hill
Keyword(s):  
Hormone Receptors ◽  
Nuclear Hormone Receptors

Role of nuclear hormone receptors in butyrate-mediated up-regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells

2007 ◽  
Vol 44 (8) ◽  
pp. 2107-2114 ◽  
Author(s):  
Markus Schwab ◽  
Veerle Reynders ◽  
Yogesh Shastri ◽  
Stefan Loitsch ◽  
Jürgen Stein ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Hormone Receptors ◽  
Nuclear Hormone Receptors

scholarly journals Dual Activities of Odorants on Olfactory and Nuclear Hormone Receptors

2009 ◽  
Vol 284 (44) ◽  
pp. 30547-30555 ◽  
Author(s):  
Horst Pick ◽  
Sylvain Etter ◽  
Olivia Baud ◽  
Ralf Schmauder ◽  
Lorenza Bordoli ◽  
...  
Keyword(s):  
Hormone Receptors ◽  
Nuclear Hormone Receptors
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