Hepatitis B vaccination of methadone maintained former heroin addicts is effective The Rockefeller University and Cornell University Medical Center*, NY, NY

Abstract Background Less than 1 in 3 US adults who initiated the 3-dose (0, 1, 6 months) hepatitis B vaccine series have completed it. HepB-CpG (Heplisav-B; Dynavax) is a new licensed adjuvanted vaccine that requires only 2 doses (0, 1 month). As part of a cluster study performed at Kaiser Permanente Southern California, we compared compliance with second dose and series completion for HepB-CpG vs. comparator vaccine (Engerix-B; GlaxoSmithKline) recipients. Methods The cohort included adults not on dialysis who received their first dose of hepatitis B vaccine in family or internal medicine departments from 8/7/2018 to 2/1/2019. Second dose compliance was assessed for the full cohort, but series completion was assessed for a subset vaccinated from August 7, 2018 to September 30, 2018 to allow at least 6 months’ follow-up. Compliance rates were estimated using the Kaplan Meier method. Adjusted hazard ratios (aHR) were estimated using Cox proportional hazard regression with robust variance to account for within medical center correlation, adjusting for age, race/ethnicity, census block income and education, prior healthcare utilization, and factors that trigger alerts for hepatitis B vaccination (diabetes and testing for sexually transmitted infections). Results There were 6500 HepB-CpG and 7733 comparator vaccine recipients (1,442 and 2,604 prior to September 30, 2018). Rates of second dose compliance at 60 days were 32.9% for HepB-CpG and 29.1% for comparator vaccine, and rates of series completion at 210 days were 56.9% and 20.6%. There was no significant difference in second dose compliance (aHR 1.14, 95% CI: 0.91, 1.47), but HepB-CpG recipients were 5 times more likely to complete the series (aHR 5.17; 95% CI: 3.84, 6.98). Second dose compliance and series completion were significantly less likely among Blacks compared with Whites and significantly more likely among Asians, adults ≥60 years compared with those < 30 years, and adults living in census blocks with a median annual income of $40,000–69,000 compared with < $40,000. Conclusion Overall, second dose compliance was similar, but series completion was better for HepB-CpG recipients than comparator vaccine recipients, suggesting that the 2-dose vaccine could lead to improvements in coverage and protection against hepatitis B virus. Disclosures All authors: No reported disclosures.

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Assessment of Adherence to Baseline Quality Measures for Cirrhosis and the Impact of Performance Feedback in a Regional VA Medical Center

American Journal of Medical Quality ◽

10.1177/1062860617736805 ◽

2017 ◽

Vol 33 (3) ◽

pp. 262-268

Author(s):

Jennifer A. Cahill ◽

Syed Rizvi ◽

Kia Saeian

Keyword(s):

Hepatitis B ◽

Performance Feedback ◽

Hepatitis A ◽

Medical Center ◽

Quality Measures ◽

Hepatitis B Vaccination ◽

Provider Performance ◽

Improvement Measures ◽

Cirrhotic Patients ◽

The Impact

Baseline adherence to cirrhotic quality improvement measures was assessed and a system to improve adherence with provider performance feedback was developed, with impact of feedback measured over time. A 6-year retrospective database was created of cirrhotic patients seen between 2006 and 2012, and reviewed for hepatitis A and B serologies, hepatocellular carcinoma (HCC) screening, variceal screening, and vaccinations. Cumulative performance feedback was distributed to providers. In all, 265 charts were reviewed retrospectively. Charts were reviewed prospectively at 30 days, 60 days, 6 months, and 12 months. Variceal screening, alpha-fetoprotein, HCC imaging, Pneumovax, lifetime influenza vaccination, hepatitis B vaccination, and hepatitis A serology compliance improved from baseline until 6 months. Hepatitis A vaccination declined at 60 days, but improved from baseline at 6 months. Hepatitis B serology improved from baseline over 12 months. Results were compared graphically. Periodic “cumulative provider performance feedback” is a simple and effective method to improve and maintain adherence to quality measures for cirrhosis.

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Knowledge, Attitude and Awareness of Hepatitis B Vaccination in Patients Visiting Jinnah Postgraduate Medical Center, Karachi

Liaquat National Journal of Primary Care ◽

10.37184/lnjpc.2707-3521.1.3 ◽

2019 ◽

Keyword(s):

Hepatitis B ◽

Medical Center ◽

Data Entry ◽

Sampling Technique ◽

Cross Sectional Study ◽

Hepatitis B Vaccination ◽

Cross Sectional ◽

Hbv Vaccine ◽

Hbv Vaccination ◽

Increased Risk

Background: Hepatitis B Virus (HBV) is a major health issue of the developing world, especially in Pakistan. Chronic Hepatitis B leads to an increased risk of liver cirrhosis and hepatocellular carcinoma and is a massive burden on the total health expenditure of the nation. However, in our country people lack knowledge regarding the HBV vaccine and its availability and have various other reasons for not getting vaccinated. The purpose of this research was to observe the attitude of patients visiting Jinnah Postgraduate Medical Center towards Hepatitis B vaccination as well as the reasons put forward by those who choose not to get vaccinated. Objectives: The aim of this study was to evaluate the knowledge, attitudes and awareness regarding HBV vaccination in patients visiting Jinnah Postgraduate Medical Center. Methodology: This is a cross sectional study that was conducted among patients who visited Jinnah Postgraduate Medical Center. 300 participants were included. The data collection method was a face-to-face interview. Non-probability convenience sampling technique was used to recruit patients. We used a self-structured, close-ended questionnaire based on the Urdu language consisting of a total of 40 questions. Prior written consent was taken. Data entry and data analysis were done by using SPSS Version 20. Results: Out of 300 participants, 63.67% of respondents had acquired matriculation or higher education while the rest were either just primary pass or illiterate. 216(72%) of the participants were aware that HBV is highly prevalent in Pakistan. 135(45%) considered alcohol and smoking as a cause of HBV. Only 43(14.3%) participants had knowledge regarding the standard dosing regimen of the vaccine. Participants had awareness about prevention. 250 (83.3%) agreed that Hepatitis B vaccination is an effective method of prevention of Hepatitis B, while 59(19.6%) thought that the vaccine itself can cause Hepatitis infection. 190(63.3%) identified cost as a barrier for vaccination. Conclusion: People in Pakistan don’t have adequate knowledge about the mode of transmission of hepatitis, but they have good knowledge about preventive methods. The prevalent attitude is to not get vaccinated due to various reasons. Hence it is very important to spread awareness among people about HBV vaccination.

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Hepatitis B vaccine knowledge and self-reported vaccination status among healthcare workers in a conflict region in northeastern Nigeria

Therapeutic Advances in Vaccines and Immunotherapy ◽

10.1177/2515135519900743 ◽

2020 ◽

Vol 8 ◽

pp. 251513551990074 ◽

Cited By ~ 1

Author(s):

Farouq Muhammad Dayyab ◽

Garba Iliyasu ◽

Bashir Garba Ahmad ◽

Abdulaziz Tijjani Bako ◽

Sepu Saraya Ngamariju ◽

...

Keyword(s):

Hepatitis B ◽

Healthcare Workers ◽

Medical Center ◽

Primary Objective ◽

Vaccination Status ◽

Hepatitis B Vaccine ◽

Good Knowledge ◽

Hepatitis B Vaccination ◽

Cross Sectional ◽

Tertiary Referral Center

Background Hepatitis B virus (HBV) infection is highly endemic in Nigeria. The primary objective of this study is to describe the knowledge, self-reported vaccination status, and intention of healthcare workers to receive hepatitis B vaccine at a tertiary referral center in conflict-ravaged northeastern Nigeria. Methods This was cross-sectional analytical study among medical practitioners, nurses, laboratory workers, health attendants, pharmacists, and radiographers working at Federal Medical Center Nguru, Yobe State. Written informed consent was obtained from all study participants. Data were obtained using questionnaires and entered into a Microsoft Excel spreadsheet, cleaned and analyzed using JMP Pro software. Results Of the 182 participants, we found that 151 (82.97%), 81 (44.51%), 85 (46.70%), and 33 (18.13%) had good knowledge of HBV, good knowledge of hepatitis B vaccine, were vaccinated against HBV by the least dose, and had a complete hepatitis B vaccination status, respectively. The lack of availability of the vaccine was the main reason for not receiving the vaccine among the unvaccinated 36/91 (39.56%), followed by not knowing where to access the vaccine 19/91 (20.88%). Conclusion The study highlights the need for strategies to ensure the availability of hepatitis B vaccine in conflict settings and need for vaccinology training given the suboptimal level of awareness and uptake of the hepatitis B vaccine among the healthcare workers.

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