Nordihydroguaiaretic acid: inter- and intrapopulational variation in the sonoran desert creosote bush (Larrea tridentata, zygophyllaceae.

1988 ◽  
Vol 16 (6) ◽  
pp. 551-555 ◽  
Author(s):  
K.R. Downum ◽  
J. Dole ◽  
E. Rodriguez
Keyword(s):  
Sonoran Desert ◽  
Nordihydroguaiaretic Acid ◽  
Larrea Tridentata ◽  
Creosote Bush ◽  
Intrapopulational Variation

Nordihydroguaiaretic Acid in Therapeutics: Beneficial to Toxicity Profiles and the Search for its Analogs

2020 ◽  
Vol 20 (2) ◽  
pp. 86-103
Author(s):  
Geraldine Sandana Mala John ◽  
Satoru Takeuchi ◽  
Ganesh Venkatraman ◽  
Suresh Kumar Rayala
Keyword(s):  
Chemical Synthesis ◽  
Recent Literature ◽  
Nordihydroguaiaretic Acid ◽  
Larrea Tridentata ◽  
Creosote Bush ◽  
Anticancer Activities ◽  
Therapeutic Applications ◽  
Chemical Derivatives ◽  
Continue Research ◽  
Derivatives Of

Nordihydroguaiaretic acid (NDGA) is a plant lignan obtained from creosote bush, Larrea tridentata and is known to possess antioxidant, anticancer activities and is used in traditional medicine in North America and Mexico. However, its prolonged consumption leads to liver damage and kidney dysfunction. Despite its toxicity and side effects, there is little awareness to forbid its consumption and its use in the treatment of medical ailments has continued over the years. Several reports discuss its therapeutic efficiency and its medical applications have tremendously been on the rise to date. There has been a recent surge of interest in the chemical synthesis of NDGA derivatives for therapeutic applications. NDGA derivatives have been developed as better alternatives to NDGA. Although several NDGA derivatives have been chemically synthesized as evidenced by recent literature, there is a paucity of information on their therapeutic efficacies. This review is to highlight the medicinal applications of NDGA, its toxicity evaluations and discuss the chemical derivatives of NDGA synthesized and studied so far and suggest to continue research interests in the development of NDGA analogs for therapeutic applications. We suggest that NDGA derivatives should be investigated more in terms of chemical synthesis with preferred conformational structures and exploit their biological potentials with future insights to explore in this direction to design and develop structurally modified NDGA derivatives for potential pharmacological properties.

scholarly journals Creosote Bush (Larrea tridentata) Phytochemical Traits and its Different uses: A Review

2021 ◽  
pp. 34-45
Author(s):  
R. E. Herrera-Medina ◽  
G. Álvarez-Fuentes ◽  
C. Contreras-Servín ◽  
J. C. García-López
Keyword(s):  
Nordihydroguaiaretic Acid ◽  
Bactericidal Effect ◽  
Larrea Tridentata ◽  
Livestock Production ◽  
Creosote Bush ◽  
Canned Food ◽  
Perennial Shrub

Creosote bush (Larrea tridentata) is a perennial shrub present in Chihuahuan, Sonoran and Mojave deserts it contains diverse metabolites; among them lignans are the most important, one of the most studied is nordihydroguaiaretic acid (NDGA), this shrub has been studied for more than seventy years due to its great variety uses. The bactericidal effect of creosote bush has been well documented, as the fungicide, nematicide, protozoa and viral effect. It has been used as an antioxidant to preserve meat in canned food. Recently research has been done on NDGA effects on anti-carcinogenic cells. There is scarce information about the use of creosote bush in livestock production. Some studies in sheep and broilers are available. The results of these research indicate that creosote bush could be used to improve productive variables in livestock and have an intestinal effect on bacteria.

EFFECT OF MANIPULATION OF WATER AND NITROGEN SUPPLIES ON THE QUANTITATIVE PHENOLOGY OF LARREA TRIDENTATA (CREOSOTE BUSH) IN THE SONORAN DESERT OF CALIFORNIA

1988 ◽  
Vol 75 (8) ◽  
pp. 1163-1174 ◽  
Author(s):  
M. R. Sharifi ◽  
F. C. Meinzer ◽  
E. T. Nilsen ◽  
P. W. Rundel ◽  
R. A. Virginia ◽  
...  
Keyword(s):  
Sonoran Desert ◽  
Larrea Tridentata ◽  
Creosote Bush ◽  
Nitrogen Supplies

scholarly journals Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Shakilur Rahman ◽  
Rizwan Ahmed Ansari ◽  
Hasibur Rehman ◽  
Suhel Parvez ◽  
Sheikh Raisuddin
Keyword(s):  
Oxidative Stress ◽  
Stress Responses ◽  
Mouse Skin ◽  
Nordihydroguaiaretic Acid ◽  
Tumor Promotion ◽  
Larrea Tridentata ◽  
Stage I ◽  
Creosote Bush ◽  
Oxidative Stress Responses ◽  
And Oxidative Stress

Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub,Larrea tridentata(Sesse and Moc. ex DC) Coville (creosote bush). It has a long history of traditional medicinal use by the Native Americans and Mexicans. The modulatory effects of topically applied NDGA was studied on acute inflammatory and oxidative stress responses in mouse skin induced by stage I tumor promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA). Double TPA treatment adversely altered many of the marker responses of stage I skin tumor promotion cascade. Pretreatment of NDGA in TPA-treated mice mitigated cutaneous lipid peroxidation and inhibited production of hydrogen peroxide. NDGA treatment also restored reduced glutathione level and activities of antioxidant enzymes. Elevated activities of myeloperoxidase, xanthine oxidase and skin edema formation in TPA-treated mice were also lowered by NDGA indicating a restrained inflammatory response. Furthermore, results of histological study demonstrated inhibitory effect of NDGA on cellular inflammatory responses. This study provides a direct evidence of antioxidative and anti-inflammatory properties of NDGA against TPA-induced cutaneous inflammation and oxidative stress corroborating its chemopreventive potential against skin cancer.

Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata)

1998 ◽  
Vol 346 (1) ◽  
pp. 77-79 ◽  
Author(s):  
Jian Luo ◽  
Tom Chuang ◽  
Jeanne Cheung ◽  
Josephine Quan ◽  
Joyce Tsai ◽  
...  
Keyword(s):  
Nordihydroguaiaretic Acid ◽  
Larrea Tridentata ◽  
Creosote Bush

A new species of Brethesiella (Hymenoptera: Encyrtidae) from California, USA, a parasitoid of Steatococcus tabernicolus (Hemiptera: Margarodidae)

Zootaxa ◽  
2006 ◽  
Vol 1167 (1) ◽  
pp. 1 ◽  
Author(s):  
VLADIMIR A. TRJAPITZIN ◽  
SERGUEI V. TRIAPITSYN
Keyword(s):  
New Species ◽  
Mojave Desert ◽  
New World ◽  
Larrea Tridentata ◽  
Creosote Bush ◽  
Type Series ◽  
A New Species

A new species of the encyrtid wasp genus Brethesiella Porter, 1920 is described from the Mojave Desert in California, USA. The type series of B. mojave sp. n. was reared from the margarodid scale Steatococcus tabernicolus Ferris on creosote bush, Larrea tridentata. The genus Aztecencyrtus Timberlake, 1926 is synonymized under Brethesiella and its two described species are transferred to the latter as B. flava (Timberlake, 1926) comb. n. and B. iceryae (Howard, 1892) comb. n. A brief review of the encyrtid parasitoids of Margarodidae, a diagnosis of Brethesiella, and an annotated key to its six described species with known females in the New World are provided.

Enterolactone and Other Lignan Metabolites as Taxon-Specifi c Markers in Modern and Ancient Woodrat Middens

2013 ◽  
Vol 68 (7-8) ◽  
pp. 327-335
Author(s):  
David A. Zinniker ◽  
Camille A. Holmgren ◽  
Bernd R. T. Simoneit
Keyword(s):  
Natural Products ◽  
Microbial Communities ◽  
Degradation Products ◽  
Nordihydroguaiaretic Acid ◽  
Structural Elements ◽  
Creosote Bush ◽  
Higher Plant ◽  
Plant Source ◽  
Related Compounds ◽  
Plant Lignans

Diversely sourced degradation products of higher plant lignans were identifi ed in modern and ancient woodrat (Neotoma) middens. The markers indicate extensive chemical modifi cation by intestinal microbial communities of mammals. The observed defunctionalized phenols represent a group of natural products, and their structural elements reveal information about the plant source. The phenols are derived mainly from two precursor types: (1) enterolactone and derivatives from conifer lignans, and (2) 2,3-bis(3’-hydroxybenzyl)butane and related compounds from lignans such as nordihydroguaiaretic acid common in Larrea sp. (e.g. creosote bush)

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