Recent study has connected obesity disorders including improper lipid, cholesterol, and glucose metabolism to lncRNAs, which may lead to obesity or type 2 diabetes. RNA sequencing and microarray analysis are helpful techniques to detect obesity-related lncRNAs. However, the important participation of several lncRNAs in controlling obesity problems is yet unexplored.Several lncRNAs interact with and influence lipid, cholesterol, and glucose metabolism genes, proteins, and enzymes. However, the number of lncRNAs found is substantially smaller than the number of lncRNAs detailing the lipid, cholesterol, and glucose metabolic activity. This is due in part to the complexity of the action mechanism of lncRNAs and the lack of reliable methodologies to predict functional properties of lncRNA. Consequently, if technologies exist to uncover and define lncRNAs connected to obesity syndrome, it will disclose possible therapeutic goals and drive the creation of novel, very useful ways for obesity therapy. Moreover, lncRNA can alter cholesterol accumulation, synthesis, intracellular transit, and excretion. Whether lncRNAs impact cholesterol homeostasis through cholesterol esterification, deesterification, and/or absorption remained unresolved till recently. It's worth highlighting that lncRNAs have poor species conservation levels. According to a recent study, about 10% of lncRNAs are preserved between mammals and chickens and 2% between mammals and fish,106 showing that preserved lncRNAs between species may play a crucial role in modulating the metabolism of obesity in animal evolution. Despite their poor conservation between species, however, most nonconservative lncRNAs have the potential to be transformed into nucleic acid medications to treat obesity syndrome in animal studies or for therapeutic advantages.LncRNAs play a function in food intake, associated with obesity diseases. LncRNA was revealed to have a role in HFD-induced obesity diseases, which have intergenerational characteristics. Complete decipherment of lncRNA with regard to metabolic control of obesity might open the way for precise medication and prevention of obesity transmission from generation to generation. Moreover, as indicated in this study review, lncRNA-based therapeutic approaches may minimize genetic toxicity and maybe treat obesity problems. Natural products may have a lot of promise in the treatment of obesity syndrome and additional studies are needed. Future investigation may focus on finding effective and nontoxic strategies to introduce lncRNA interference agents to obese patients via natural products and gene therapy. As a consequence, discovering a unique mechanism for influencing obesity on the expression of lncRNA might help us better understand the pathophysiology of obesity syndromes and support the design of new tools to prevent and cure obesity syndrome, especially from food.