Purpose: The use of technology (e.g., telehealth) in clinical settings has rapidly increased and its use in research settings continues to grow. The aim of this report is to provide detailed methods for conducting a multi-timepoint (test-retest) virtual paradigm, assessing lifestyle, physiological, cognitive, and linguistic factors in persons with and without aphasia. Methods: Procedures for virtual assessment are detailed in a sample of non-brain damaged adults (NB; N=24) and persons with aphasia (PWA; N=9) on a test-retest paradigm (data collection approximately 10 +/- 3 days apart). This report provides practical information about pre-assessment (e.g. recruitment, scheduling), assessment (e.g. aphasia-friendly consent presentation, investigator fidelity), and post-assessment (e.g. data storage, quality check) procedures for human behavior research using a virtual platform.Results: Preliminary study data is provided, demonstrating high retention rates and feasibility. Common technological troubles and solutions are discussed, and solutions offered. The results suggest that our pre-assessment, assessment, and post-assessment procedures were core to the success of our study. Conclusion: We provide practical methodology for conducting a multi-timepoint study, with considerations for persons with aphasia, adding to the body of research on telehealth in clinical populations. Future studies should continue to evaluate tele-methodology, which may be core for diversifying studies, improving study retention, and enrolling larger sample sizes.