TELMISARTAN AND AZELNIDIPINE QUANTIFICATION EMPLOYING HPLC STRATAGEM; STABILITY INVESTIGATION ON TELMISARTAN AND AZELNIDIPINE

Objective: The focus of our research was to create a fairly sensitive HPLC stratagem for determining telmisartan (TLM) and azelnidipine (AEL) in bulk and tablet types. Methods: Analysis of TLM and AEL was performed on a “C18 Kromasil stationary column (5 µm, 250 mm × 4.6 mm)”. The mobile phase was made of 0.1M NaH2PO4 solution (pH 3.5) and methanol at a comparative volume ratio of 50% each. The analysis of TLM and AEL was isocratic, with the flow velocity adjusted at 1.0 ml/min and indeed, the TLM and AEL analysis was done at 256 nm using a PDA device sensor. TLM and AEL were stressed with acid, peroxide, dry heat, alkali, and sunlight-induced settings. Results: The retention/elution periods for the TLM and AEL were observed at 2.225 min and 3.178 min, respectively. The HPLC stratagem developed have a straight-line relation with relative concentrations in the ranges of 20-60 µg/ml for TLM and 4-12 µg/ml for AEL. The LOQ’s for TLM and AEL were 0.2516 μg/ml and 0.0871 μg/ml, respectively. The validation investigational findings done for TLM and AEL with the established sensitive HPLC stratagem were passed out in conformity with the ICH standards. Conclusion: The established sensitive HPLC stratagem was shown as competent for the quality check of bulk samples of TLM and AEL throughout batch release as well as in the course of TLM and AEL stability investigations.

Editorial Notes: Issues in Islamic Economics, Banking and Financial Institutions during the Covid-19 Pandemic

In this second issue of the 2021 edition, we mostly received manuscripts discussing the challenges of Islamic Banking and Financial Institutions (IBFIs) within the Covid-19 pandemic. Specifically, they discuss various topics within the field, such as institutional and employees' performances, financial stability, waqf institutions, the trend of Islamic economics research, and the relevance of Islamic economics and finance essential components to the modern economy. Approaching the publication deadline, only ten were accepted out of the dozen manuscripts that were reviewed. Nine were ready for publication, while the rest still needed quality improvements. As for the process, each manuscript will have to pass an initial review from our editor(s) before forwarding it to suitable reviewers. Some manuscripts would have to go through several rounds before being accepted. The reviewers' feedback was taken into consideration to provide the final decisions. Following that, the manuscripts would have to pass the editing stages, including proof-reading and layout, where our editor(s) will intensely communicate with the authors if needed. It is to ensure that each published manuscript has undergone a quality check. Interestingly, of the published articles, five of them discuss the performance issues in Islamic financial institutions, whilst the rest discuss Islamic economics and financial matters in other topics ranging from waqf institutions, the trend of Islamic economics research, to the relevance of Islamic economics and finance essential components to the modern economy. Please check the PDF file for detailed information.

Overall Equipment Utilisation (OEU) Monitoring and Remote Quality Check in Legacy Machine with Raspberry Pi

Overall Equipment Utilisation (OEU) plays an important role as a benchmark for manufacturing companies to determine each machine's efficiency. Currently, there is no proper OEU measurement system in legacy machines and only relies on human observation. This project aims to develop a measurement of OEU system by using Optical Character Recognition (OCR). An efficient Optical Character Recognition (OCR) algorithm is needed to have a high percentage of recognition rate. The outcome of this project will be a Graphical User Interface (GUI) that display real-time OEU monitoring and remote quality check for legacy machines. Pytesseract-OCR Version 4 classifier using the Recurrent Neural Network (RNN) method has been proposed in this paper. Furthermore, an error detection feature is designed from OCR output.

Normalisation of SARS-CoV-2 concentrations in wastewater: the use of flow, conductivity and CrAssphages

Over the course of the COVID-19 pandemic in 2020-2021, monitoring of SARS-CoV-2 RNA in wastewater has rapidly evolved into a supplementary surveillance instrument for public health. Short term trends (2 weeks) are used as a basis for policy and decision making on measures for dealing with the pandemic. Normalization is required to account for the varying dilution rates of the domestic wastewater, that contains the shedded virus RNA. The dilution rate varies due to runoff, industrial discharges and extraneous waters. Three normalization methods using flow, conductivity and CrAssphage, have been investigated on 9 monitoring locations between Sep 2020 and Aug 2021, rendering 1071 24-hour flow-proportional samples. In addition, 221 stool samples have been analyzed to determine the daily CrAssphage load per person. Results show that flow normalization supported by a quality check using conductivity monitoring is the advocated normalization method in case flow monitoring is or can be made available. Although Crassphage shedding rates per person vary greatly, the CrAssphage loads were very consistent over time and space and direct CrAssphage based normalization can be applied reliably for populations of 5600 and above.

Analysis of the quality of design documentation for the construction of an apartment building

Within the framework of this article, the analysis of the current situation in the construction industry of the Russian Federation, current scientific and regulatory methods of conducting a high-quality check of the developed design documentation for an apartment building is carried out. The author of the article in the work considers measures that allow to effectively conduct a comprehensive assessment of the effectiveness of design solutions from a technological and regulatory point of view, as well as take into account the entire range of environmental, social, external economic and other consequences that are the result of decisions made.

Onsite Quality Check for Installation of Prefabricated Wall Panels Using Laser Scanning

Prefabricated construction has gained increasing popularity to meet the needs of rapid city development in recent years. Installation quality check is a critical task in prefabricated construction, and currently mostly still carried out manually, which is slow and ineffective. To provide an efficient and practical quality check method to replace the current manual method, this paper elaborates on an approach for checking prefabricated wall panels using laser scanning. The approach is validated in an actual case study. A common laser scanner BLK 360 is adopted to collect onsite 3D scenes after panel installation. The point clouds collected are co-roistered, classified, and segmented. Geometric parameters such as angles and distances allow for determining whether the installation meets the quality requirement. The outcome is compared with the quality check results using the conventional manual method. The results show that the panels, which need rectification, are correctly identified by the proposed approach. The major contribution of this study is determining the set of segmentation parameters to be adopted in similar quality check-up procedures. A practical and efficient quality check process is also proposed and can be readily implemented for certain prefabricated elements in many construction cases.

Review on Classical Preparatory Methods of Rasa Dravyaas

The Ayurveda term Rasashaastra merely involves science of mercury (Parada). This specialized modality works around mineral, metal and precious elements. The drugs or raw materials utilized under category of Rasashaastra are known as ‘Rasa dravyaas’. These drugs offer several therapeutic responses and imparts excellent pattern of drug absorption, assimilation and quick action. Rasa dravyaas are utilized for treating diseases of skin, digestive system, respiratory system, reproductive system and excretory system, etc. The metal and mineral based products are prepared using specific procedures of purification, mixing, heating, incineration and size reduction, etc. The procedures involves in the preparation of these drugs provides particular characteristics in formulation therefore it is very essential to prepare Rasa dravyaas as per the specified protocol with great precaution, the error in preparation of Rasa dravyaas can hamper quality of drugs and also responsible for adverse reaction. Thus ancient Ayurveda philospher advocated that a learned person should involve in the preparation of Rasa dravyaas with quality check in each step. Present article explores classical preparatory methods of Rasa Dravyaas. Keywords: Ayurveda, Rasashaastra, Rasa dravyaas, Parada