Characterization of β-cyclodextrin for direct compression tableting

1994 ◽  
Vol 101 (1-2) ◽  
pp. 71-80 ◽  
Author(s):  
Girish S. Pande ◽  
Ralph F. Shangraw
Keyword(s):  
Direct Compression

scholarly journals Preparation and Characterization of Highly Porous Direct Compression Carrier Particles with Improved Drug Loading During an Interactive Mixing Process

2010 ◽  
Vol 11 (2) ◽  
pp. 698-707 ◽  
Author(s):  
Mingna Song ◽  
Ning Li ◽  
Louwrens R. Tiedt ◽  
Michael D. Degennaro ◽  
Melgardt M. de Villiers
Keyword(s):  
Drug Loading ◽  
Direct Compression ◽  
Mixing Process ◽  
Highly Porous

scholarly journals DESIGN AND CHARACTERIZATION OF CHLORZOXAZONE FLOATING BIOADHESIVE DRUG DELIVERY SYSTEM

2018 ◽  
Vol 11 (11) ◽  
pp. 222
Author(s):  
Manish Kumar Pal ◽  
Ganesh Deshmukh
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
The Other ◽  
Direct Compression ◽  
Total Dosage ◽  
Carbopol 934P

Objective: The objective of the work is to formulate chlorzoxazone floating bioadhesive tablets which will significantly improve the bioavailability of drugs under the condition of prolonged use of drugs and reduce the total dosage of administered drug and reduce the side effect.Methods: Floating bioadhesive tablet was prepared by direct compression of polymer such as HPMCK4M and Carbopol934p in combination.Result: After analysis of different evaluation parameter and drug release, F9 batch was selected as promising formulation for delivery of chlorzoxazone floating bioadhesive tablets with 92.1% drug release at 12th h.Conclusion: It was observed that the combination of polymers in 22.5% (HPMCK4M) and 12.5% (Carbopol 934p) give the best drug release and sustain the drug release for 12 h. Among the other batches, F9 batch was selected as an optimized batch because the pre- and post-compression parameters results are satisfactory.

Characterization of acid modifiedDioscoreastarches as direct compression excipient

2009 ◽  
Vol 14 (3) ◽  
pp. 259-270 ◽  
Author(s):  
Oluwatoyin A. Odeku ◽  
Katharina M. Picker-Freyer
Keyword(s):  
Direct Compression

scholarly journals FORMULATION AND CHARACTERIZATION OF MUCOADHESIVE MATRIX TABLET OF NIZATIDINE

2018 ◽  
Vol 11 (6) ◽  
pp. 277
Author(s):  
Saritadevi Gupta ◽  
Asish Dev
Keyword(s):  
Drug Release ◽  
Ethyl Cellulose ◽  
Matrix Tablets ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Total Dosage ◽  
Equal Concentration ◽  
Compression Parameter ◽  
Carbopol 934P

Objective: The objective of the work is to formulate nizatidine mucoadhesive matrix tablets which will significantly improve the bioavailability of drugs under the condition of prolonged use of drugs and reduce the total dosage of administered drug and reduce the side effect.Method: Matrix tablet was prepared by direct compression of polymer such as HPMC K4M, carbopol-934p, and ethyl cellulose alone and in combination.Result: After analysis of different evaluation parameter and drug release, F9 batch was selected as promising formulation for delivery of nizatidine as a mucoadhesive matrix tablet with 94.18% drug release at the 12th h.Conclusion: It was observed that the combination of both polymers in equal concentration gives the best drug release and sustains the drug release for 12 h. Among the other batches, F9 batch was selected as an optimized batch because the pre- and post-compression parameter results are satisfactory.

scholarly journals DEVELOPMENT AND CHARACTERIZATION OF DIRECT COMPRESSED MATRIX MINI TABLETS OF NAPROXEN SODIUM

2018 ◽  
Author(s):  
Oyeniran Taiwo Opeyemi ◽  
Obanewa opeyemi Adegbenro
Keyword(s):  
Naproxen Sodium ◽  
Direct Compression ◽  
Compatibility Studies ◽  
High Quality ◽  
Rate Study ◽  
In Vitro Performance ◽  
Pvp K30 ◽  
Good Flow

The present study was carried out to formulate and evaluate multiparticulate system containing mini-tablets of Naproxen sodium. Naproxen is a nonsteroidal anti-inflammatory drug (NSAIDs) with analgesic and antipyretic properties. Pre-formulation studies showed good flow and compaction capacity, leading to the production of high quality mini-tablets. The drug-excipients compatibility studies were performed using FTIR techniques. Ten different matrix mini tablets were manufactured by direct compression using various polymers like HPMC K4M, PVP K30 in different ratio. The prepared mini tablets were subjected to pre and post compressional parameters and the values were within the prescribed limits. The in-vitro performance showed the desired biphasic behaviour. Drug release from matrix mini tablets was sustained over a period of 10 hours and release rate. Study concludes that Naproxen sodium can be successfully released in a controlled manner by the use of developed matrix mini-tablets.

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