Protective effects of Osbeckia octandra against galactosamine and tert-butyl hydroperoxide induced hepatocyte damage

1995 ◽  
Vol 49 (2) ◽  
pp. 69-76 ◽  
Author(s):  
M.Ira Thabrew ◽  
Christopher D. Gove ◽  
Robin D. Hughes ◽  
Ian G. McFarlane ◽  
Roger Williams
Keyword(s):  
Protective Effects ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Hepatocyte Damage

scholarly journals Protective Effects of Saponin Mixture, Isolated from <i>Astragalus monspessulanus</i> subsp. <i>monspessulanus</i> on Tert-Butyl Hydroperoxide—Induced Oxidative Stress in Isolated Rat Hepatocytes

2015 ◽  
Vol 06 (06) ◽  
pp. 799-803 ◽  
Author(s):  
Magdalena Spasova Kondeva-Burdina ◽  
Viktor Bratkov ◽  
Rumyana Lubomirova Simeonova ◽  
Vessela Bisserova Vitcheva ◽  
Ilina Nikolaeva Krasteva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Hepatocytes ◽  
Protective Effects ◽  
Isolated Rat Hepatocytes ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Isolated Rat

Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes

2010 ◽  
Vol 48 (10) ◽  
pp. 2980-2987 ◽  
Author(s):  
Mingcang Chen ◽  
Honggang Gu ◽  
Yiyi Ye ◽  
Bing Lin ◽  
Lijuan Sun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Hepatocytes ◽  
Protective Effects ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

Protective effects of Hibiscus tiliaceus L. methanolic extract to V79 cells against cytotoxicity and genotoxicity induced by hydrogen peroxide and tert-butyl-hydroperoxide

2007 ◽  
Vol 21 (8) ◽  
pp. 1442-1452 ◽  
Author(s):  
Renato Moreira Rosa ◽  
Dinara Jaqueline Moura ◽  
Maria Inês S. Melecchi ◽  
Rafael Santos dos Santos ◽  
Marc François Richter ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Methanolic Extract ◽  
Protective Effects ◽  
V79 Cells ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

The Effect of Tert-butyl Hydroperoxide on Peritoneal Macrophages and the Protective Effect of Protein-bound Polysaccharide Administered Intraperitoneally and Orally

1998 ◽  
Vol 26 (03n04) ◽  
pp. 301-310 ◽  
Author(s):  
Mei Zhou ◽  
Yuan Chen ◽  
Qian Ouyang ◽  
Shangxi Liu ◽  
Zhan-Jun Pang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Morphological Changes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Peritoneal Macrophages ◽  
Protective Effects ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

Our previous studies have shown that a protein-bound polysaccharide, polysaccharide krestin (PSK), can protect macrophages from lipoperoxidative injury induced by tert-butyl hydroperoxide (tbOOH) and oxidatively modified low density lipoprotein (O-LDL). PSK was administered intraperitoneally to mice, and the peritoneal macrophages harvested were used as an experimental model. PSK does not reveal any protective effect on macrophages injured by tbOOH when incubated in vitro. In order to elucidate its mode of action, in the present study, the protective effects of PSK were further investigated using morphological changes and viability as indices. It was shown that, compared with the non-PSK group, the viability of macrophages was much higher in the PSK group, and the morphological changes in the PSK group were much less than those in the non-PSK group. The protective effect of PSK administered intraperitoneally and orally on macrophages injured by tbOOH was comparable. Furthermore, the serum of the PSK treated mice had the same protective effect.

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