A single dose of morphine sulfate increases the incidence of vomiting after outpatient inguinal surgery in children

A single dose (10 mg/70 kg) of morphine sulfate was administered to 18 male chronic schizophrenics, using a double-blind procedure. Performance on 29 physiological and sensory variables was measured. Only on two variables was there any statistically significant effect.

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Can single dose preoperative intrathecal morphine sulfate provide cost-effective postoperative analgesia and patient satisfaction during radical prostatectomy in the current era of cost containment?

Prostate Cancer and Prostatic Diseases ◽

10.1038/sj.pcan.4500584 ◽

2002 ◽

Vol 5 (3) ◽

pp. 226-230 ◽

Cited By ~ 10

Author(s):

J A Eandi ◽

R W de Vere White ◽

H S G R Tunuguntla ◽

C H Bohringer ◽

C P Evans

Keyword(s):

Patient Satisfaction ◽

Single Dose ◽

Radical Prostatectomy ◽

Postoperative Analgesia ◽

Cost Containment ◽

Intrathecal Morphine ◽

Cost Effective ◽

Morphine Sulfate

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Evaluation of a single-dose of intravenous magnesium sulphate for prevention of postoperative pain after inguinal surgery

Indian Journal of Anaesthesia ◽

10.4103/0019-5049.76605 ◽

2011 ◽

Vol 55 (1) ◽

pp. 31 ◽

Cited By ~ 20

Author(s):

Shashi Kiran ◽

Rachna Gupta ◽

Deepak Verma

Keyword(s):

Single Dose ◽

Postoperative Pain ◽

Magnesium Sulphate ◽

Intravenous Magnesium ◽

Inguinal Surgery

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Relative oral bioavailability of morphine and naltrexone derived from crushed morphine sulfate and naltrexone hydrochloride extended-release capsules versus intact product and versus naltrexone solution: A single-dose, randomized-sequence, open-label, three-way crossover trial in healthy volunteers

Clinical Therapeutics ◽

10.1016/j.clinthera.2010.05.011 ◽

2010 ◽

Vol 32 (6) ◽

pp. 1149-1164 ◽

Cited By ~ 18

Author(s):

Franklin K. Johnson ◽

Jeffrey G. Stark ◽

Frederick A. Bieberdorf ◽

Joe Stauffer

Keyword(s):

Single Dose ◽

Healthy Volunteers ◽

Oral Bioavailability ◽

Extended Release ◽

Crossover Trial ◽

Morphine Sulfate ◽

Open Label ◽

Naltrexone Hydrochloride

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Comparison of Single Dose Diclofenac Sodium Vs Paracetamol Suppository for Pain Relief Following Inguinal Surgery in Children

Indian Journal of Anaesthesia and Analgesia ◽

10.21088/ijaa.2349.8471.6619.24 ◽

2019 ◽

Vol 6 (6 (P-1)) ◽

pp. 2013-2018

Author(s):

Ravindra Bhat R ◽

◽

Murugananth N ◽

Vasudevan A ◽

Hemavathy B ◽

...

Keyword(s):

Single Dose ◽

Pain Relief ◽

Diclofenac Sodium ◽

Inguinal Surgery

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The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053929 ◽

1982 ◽

Vol 40 ◽

pp. 252-253

Author(s):

D.E. Philpott ◽

W. Sapp ◽

C. Williams ◽

J. Stevenson ◽

S. Black ◽

...

Keyword(s):

Stem Cell ◽

Single Dose ◽

B Cell ◽

Cell Survival ◽

Spermatogonial Stem Cell ◽

Low Doses ◽

Particle Irradiation ◽

Stem Cell Survival ◽

Irradiation Injury ◽

Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

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Gastric Ulcers Produced by Cisplatin

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100099337 ◽

1981 ◽

Vol 39 ◽

pp. 582-583

Author(s):

S.K. Aggarwal ◽

J. San Antonio

Keyword(s):

Electron Microscopy ◽

Single Dose ◽

Side Effects ◽

Antitumor Agent ◽

Gastric Ulcers ◽

Enzyme Cytochemistry ◽

Intestinal Toxicity ◽

Ovarian Cancers ◽

Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

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Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: A randomized, double-blind single-dose study

Clinical Pharmacology & Therapeutics ◽

10.1016/s0009-9236(99)90073-5 ◽

1999 ◽

Vol 66 (6) ◽

pp. 625-635

Author(s):

E BREIVIK ◽

P BARKVOLL ◽

E SKOVLUND

Keyword(s):

Single Dose ◽

Oral Surgery ◽

Double Blind ◽

Single Dose Study ◽

Dose Study

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