Tracheobronchial mucoepidermoid carcinoma in childhood with a ten year follow-up

1990 ◽  
Vol 4 (2) ◽  
pp. 112-113 ◽  
Author(s):  
K WATTERSON ◽  
J WISHEART
Keyword(s):  
Mucoepidermoid Carcinoma

Long-term follow-up of a multimodally managed pulmonary mucoepidermoid carcinoma in a cat

2021 ◽  
Vol 163 (4) ◽  
pp. 295-300
Author(s):  
R. Lamolet ◽  
M. Manassero ◽  
E. Reyes-Gomez ◽  
J. Béguin
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Long Term Follow Up

Warthin Tumor–Like Mucoepidermoid Carcinoma

2017 ◽  
Vol 26 (1) ◽  
pp. 31-33 ◽  
Author(s):  
Nicholas Heatley ◽  
Kevin J. Harrington ◽  
Khin Thway
Keyword(s):  
Lymphoid Tissue ◽  
Mucoepidermoid Carcinoma ◽  
Benign Neoplasm ◽  
Warthin Tumor

Mucoepidermoid carcinoma (MEC) shows a wide morphologic spectrum, including epithelium with oncocytic or squamous metaplastic changes overlying a prominent cystic architecture, as well as tumor-associated lymphoid tissue. We illustrate a case of MEC of the parotid in a 17-year-old female, in which all these features occurred extensively, such that they accounted for almost the entire neoplasm, and closely mimicked Warthin tumor histologically. This highlights the need for diagnostic awareness of this particular morphologic variant of MEC, as patients could potentially be inappropriately discharged from follow-up if diagnosed with a benign neoplasm.

scholarly journals Mucoepidermoid Carcinoma in a Minor Salivary Gland in a Child

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Fatih Sengul ◽  
Sera Simsek ◽  
Binali Cakur
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Mucoepidermoid Carcinoma ◽  
Minor Salivary Gland ◽  
Differential Diagnoses ◽  
Common Site ◽  
Radiological Findings ◽  
Pathologic Lesions ◽  
A Minor

Mucoepidermoid carcinoma (MEC), one of the most common salivary gland malignancies, is rare in children. MEC mainly occurs in the parotid gland, along with minor glands being the second common site, particularly in palate. Clinical, histological, and radiological findings of palatal MEC in a 12-year-old girl are presented with three-year follow-up. Pathologic lesions must be considered in differential diagnoses of intraoral asymptomatic lesions, and their detailed inspection should be taken into consideration.

scholarly journals Endobronchial Mucoepidermoid Carcinoma in a child

2021 ◽  
Author(s):  
Sara Fonseca ◽  
Sónia Silva ◽  
Adriana Magalhães ◽  
Rita Lago ◽  
Norberto Estevinho ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Invasive Procedure ◽  
Rigid Bronchoscopy ◽  
Functional Improvement ◽  
Low Grade ◽  
Polypoid Mass ◽  
Exertional Dyspnea ◽  
Chronic Respiratory Insufficiency ◽  
Laser Excision

Endobronchial mucoepidermoid tumors are rare neoplasms but most cases are reported in children. Due to nonspecific symptoms, diagnosis can be challenging, but early diagnosis and treatment are crucial for prognosis. We present the case of a boy, with chronic respiratory insufficiency due to bronchiolitis obliterans, that presented worsening exertional dyspnea at 12 years. Spirometry showed a frank deterioration of respiratory function and CT scan revealed an obstructive polypoid mass in the intermediate bronchus. Given the severe basal ventilatory compromise and risk associated with surgical treatment, rigid bronchoscopy and laser excision, and photocoagulation were performed, with clinical and functional improvement. The histological examination revealed a low-grade mucoepidermoid carcinoma. The option for a minimally invasive procedure requires careful follow-up due to the risk of tumor recurrence.

scholarly journals Reevaluation of Salivary Lymphadenoma

2020 ◽  
Author(s):  
Chunye Zhang ◽  
Ting Gu ◽  
Yuhua Hu ◽  
Jingjing Sun ◽  
Ronghui Xia ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Epithelial Cells ◽  
Mucoepidermoid Carcinoma ◽  
Clinicopathologic Features ◽  
Prognostic Features ◽  
Lymphoid Stroma ◽  
Histologic Evaluation ◽  
Age Range

Context.— Both salivary lymphadenomas (LADs) and Warthin-like mucoepidermoid carcinoma (MEC) contain components of epithelium and lymphoid stroma and their differential diagnosis can be difficult on the basis of morphology alone. Objective.— To clarify whether Warthin-like MEC was diagnosed as a LAD, and to compare their clinicopathologic features. Design.— A total of 16 LAD cases were analyzed for MAML2 rearrangement by using fluorescence in situ hybridization, and the clinical, histologic, immunohistochemical, and prognostic features were compared between MAML2 rearrangement–positive and MAML2 rearrangement–negative groups. Results.— Among the 16 cases investigated, 9 harbored a MAML2 rearrangement and were reclassified as Warthin-like MEC. The remaining 7 cases were classified as LADs with 1 nonsebaceous and 6 sebaceous cases. The patients with Warthin-like MEC had a wider age range (10–75 years) than the patients with LADs (36–68 years). Histologically, 2 of the 9 Warthin-like MECs (22.2%) showed focal invasion, whereas all the LADs had complete capsules. Warthin-like MECs exhibited a diverse epithelial cell morphology, including basaloid, glandular, cuboidal, epidermoid, with mucinous cells, although these cytologic features were seen only focally in some cases. Nonsebaceous LAD was composed of basaloid and glandular epithelial cells predominantly. In sebaceous LAD, the epithelial cells were composed of basaloid and large foamy sebaceous cells. In all cases, the stroma was composed mainly of lymphocytes accompanied by lymphoid follicles, although plasma cell infiltration could be much heavier in Warthin-like MEC. All the patients had a good outcome after a longer follow-up (3∼166 months). Conclusions.— Warthin-like MEC can be misdiagnosed as a LAD owing to overlap in clinicopathologic features of the 2 entities. Careful histologic evaluation and detection of MAML2 rearrangement can facilitate their differential diagnosis.

Clinical, Pathological, and Genomic profiles of Salivary Warthin tumor-like Mucoepidermoid Carcinoma

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S87-S87
Author(s):  
B Li
Keyword(s):  
Transition Zone ◽  
Mucoepidermoid Carcinoma ◽  
Fish Analysis ◽  
Warthin Tumor ◽  
Molecular Features ◽  
Whole Exome ◽  
Main Driver ◽  
Driver Event

Abstract Introduction/Objective Warthin tumor-like mucoepidermoid carcinoma(WTL- MEC) is one of the subvariant of mucoepidermoid carcinoma. It mimics the histological features of metaplastic Warthin tumors (mWTs). To investigate the clinicopathological, molecular features, and bio-behaviors of WTL-MEC, we retrospected a cohort of 29 WTL- MEC patients. Methods/Case Report The clinicopathological and microscopic data were collected. Dual-color FISH analysis was performed on paraffin-embedded sections of 29 WTL- MEC patients and 16 mWTs patients using a MAML2 break- apart probe. Whole-exome sequencing and whole transcription sequencing were performed on 3 WTL-MEC and 3 typical mucoepidermoid carcinomas (TMEC) patients. Genetic data were bioinformatically analyzed by software MuTect (v1.7), PINDEL (v0.2.5), SnpEff (v3.0), and etc. Results (if a Case Study enter NA) The cohort of WTL-MEC included 10 male and 19 female patients with a median age of 42.3 years (range, 8 to 68 years). Microscopically, the WTL-MEC lesion consisted of multi-cysts with variant shapes and sizes. The cystic spaces were lined by bi-layered and multilayered oncocytic cells. A transition zone between the bi-layered oncocytic epithelium to the multilayered oncocytic epithelium was observed in WTL-MEC. The cords of epidermoid cells and mucous cells could be found. The germinal center, extensive hyalinization, and mucus extravasation were observed. MAML2 rearrangement was identified in 29 (100%) WTL-MEC. No rearrangement was observed in mWTs by FISH. MET was the most commonly mutated gene in TMEC, and PRDM11 was the most commonly mutated gene in WTL-MEC. Twenty-nine patients were alive without recurrent at the end of the follow-up periods(5–128M). One Patient died due to the metastasis to the lung. Conclusion compared with mWTs, WTL- MEC usually presented in the young, non-smoking female. The histological feature of WTL-MEC depended mainly on the transition zone of the bi-layered oncocytic epithelium and the multilayered oncocytic epithelium. And MAML2 status can confirm the diagnosis. CRTC1-MAML2 and PRDM11 mutations appear to be the main driver event of WTL-MEC. Prognosis was usually favorable, but recurrence or metastasis may rarely occur.

scholarly journals Treatment of Tracheal Mucoepidermoid Carcinoma by Argon Plasma Coagulation During Pregnancy

2015 ◽  
Vol 100 (5) ◽  
pp. 927-929 ◽  
Author(s):  
Assaad Kesrouani ◽  
Georges Dabar ◽  
Samir Rahal ◽  
Claude Ghorra
Keyword(s):  
Cesarean Section ◽  
Mucoepidermoid Carcinoma ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
Tracheobronchial Tree ◽  
Caucasian Woman ◽  
Plasma Coagulation ◽  
Tumor Bed ◽  
First Case

Mucoepidermoid carcinoma of the tracheobronchial tree is a rare airway tumor (<1% of all lung tumors). In adults, the majority of primary tracheal tumors are malignant. Management during pregnancy is complex and requires weighing maternal and fetal prognosis. Reported cases describe surgical resection following cesarean section. We report the first case to be treated by Argon-Plasma Coagulation (APC) in pregnancy. A 35-year-old Caucasian woman G1P0, at 27 weeks of gestation was admitted to the emergency department because of hemoptysis and severe dyspnea. Bronchoscopy and biopsies diagnosed primary tracheal mucoepidermoid carcinoma. Following an episode of tracheal bleeding, she was intubated. After thorough explanations to the family and obtaining informed consent, therapeutic bronchoscopy, under general anesthesia using a rigid bronchoscope, was performed. The tumor was cored out with the tip of the bronchoscope and removed with an alligator forceps. The tumor bed was coagulated with APC. The obstetrical team was ready to intervene in case of maternal emergency. Immediate follow-up was good, and she left the hospital 4 days later. She delivered at 39 weeks of gestation by cesarean section because of dystocia. Five years later, the patient is doing well without any signs or symptoms of recurrence. Pediatric follow-up is normal. Argon Plasma Coagulation for treatment of mucoepidermoid tracheal carcinoma is feasible during pregnancy. Reporting this case could lead to less aggressive management of mucoepidermoid carcinoma in pregnant patients.

Central mucoepidermoid carcinoma of the mandible: report of four cases with long-term follow-up

2003 ◽  
Vol 32 (4) ◽  
pp. 378-382 ◽  
Author(s):  
F.R. Pires ◽  
O. Paes de Almeida ◽  
M.A. Lopes ◽  
D. Elias Da Cruz Perez ◽  
L.P. Kowalski
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Long Term Follow Up ◽  
Central Mucoepidermoid Carcinoma

Multiple malignancies in a patient with bilateral retinoblastoma

1998 ◽  
Vol 112 (2) ◽  
pp. 189-192 ◽  
Author(s):  
H. M. Eha ◽  
A. J. M. Balm ◽  
D. de Jong ◽  
L. J. Van't Veer
Keyword(s):  
Squamous Cell Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Second Primary ◽  
Cytotoxic Therapy ◽  
Carcinogenic Effect ◽  
Left Lower Extremity ◽  
Bilateral Retinoblastoma ◽  
Second Primary Malignancies ◽  
The Right

AbstractA case is presented of a patient with bilateral retinoblastoma, treated at infancy with surgery, chemotherapy and radiotherapy, who subsequently developed at least four additional histologically distinct malignancies: a Ewing sarcoma of the left fibula, two extraskeletal osteosarcomas of the left lower extremity, a mucoepidermoid carcinoma of the right parotid gland and a squamous cell carcinoma of the left paranasal cavity.In addition to retinoblastoma, patients with a germline RB-1 mutation are at high risk of second primary malignancies. An additive carcinogenic effect of cytotoxic therapy in these patients has been assumed. Patients with hereditary retinoblastoma should be under life-long follow-up programmes including a regular head and neck examination for detection of new primaries, especially in the radiation field of the presenting retinoblastoma.

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