THE ROLE OF RNA PROCESSING IN GENE EXPRESSION**This paper is dedicated to Dan Mazia, whose inspirational review and analysis of the Cell Division Problem (1), which I read as a graduate student, had a considerable influence on my decision to pursue a career in cell biology.11This work was supported by grants from the National Science Foundation and U.S. Public Health Service, and an appropriation from the Commonwealth of Pennsylvania.

1978 ◽  
pp. 33-46
Author(s):  
Robert P. Perry
Keyword(s):  
Public Health ◽  
Gene Expression ◽  
Cell Division ◽  
Health Service ◽  
Graduate Student ◽  
Cell Biology ◽  
Division Problem ◽  
Considerable Influence ◽  
National Science

scholarly journals The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes

2020 ◽  
Vol 295 (34) ◽  
pp. 12045-12057
Author(s):  
Christina Schoenherr ◽  
Adam Byron ◽  
Billie Griffith ◽  
Alexander Loftus ◽  
Jimi C. Wills ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cell Biology ◽  
Protein Complexes ◽  
Transcriptional Regulators ◽  
Adaptor Proteins ◽  
Nuclear Pore ◽  
Biochemical Fractionation

Ambra1 is considered an autophagy and trafficking protein with roles in neurogenesis and cancer cell invasion. Here, we report that Ambra1 also localizes to the nucleus of cancer cells, where it has a novel nuclear scaffolding function that controls gene expression. Using biochemical fractionation and proteomics, we found that Ambra1 binds to multiple classes of proteins in the nucleus, including nuclear pore proteins, adaptor proteins such as FAK and Akap8, chromatin-modifying proteins, and transcriptional regulators like Brg1 and Atf2. We identified biologically important genes, such as Angpt1, Tgfb2, Tgfb3, Itga8, and Itgb7, whose transcription is regulated by Ambra1-scaffolded complexes, likely by altering histone modifications and Atf2 activity. Therefore, in addition to its recognized roles in autophagy and trafficking, Ambra1 scaffolds protein complexes at chromatin, regulating transcriptional signaling in the nucleus. This novel function for Ambra1, and the specific genes impacted, may help to explain the wider role of Ambra1 in cancer cell biology.

scholarly journals The 1955 Salk Polio Vaccine and the 1957-61 Niles Leukemia Cluster: A Flawed Investigation by the U.S. Public Health Service

2002 ◽  
Vol 69 (2) ◽  
pp. 169-175
Author(s):  
Herbert Ratner
Keyword(s):  
Public Health ◽  
Health Service ◽  
Physical Environment ◽  
Public Health Service ◽  
Second Graders ◽  
Polio Virus ◽  
Polio Vaccine ◽  
Cluster A ◽  
The U.S

A 1963 U.S. Public Health Service study of the 1957-1961 leukemia cluster of eight children in Niles, IL, gave cursory attention to the possible role of the Salk polio vaccine in the etiology of the leukemia. Entitled “Leukemia among Children in a Suburban Community,” and published in the American Journal of Medicine, 34:796-812 June, 1963, the study was reprinted as a “Classic in Oncology” in CA — A Cancer Journal for Clinicians, 40, 1:27-50 Jan.-Feb., 1990. Focusing on the physical environment of the school and church community to which six of the children belonged, the study either overlooked or ignored the presence of live polio virus in the first two inoculations received by first and second graders in Chicago and its suburbs in the spring of 1955. Had the investigators considered the 1955 vaccine as a vector of the disease, their conclusions might have been other than to say the etiology of the leukemia cluster could not be determined.

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