Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications

Abstract Antimicrobial resistance not only increases the contagiousness of infectious diseases but also a threat for the future as it is one of the health care concern around the globe. Conventional antibiotics are unsuccessful in combating chronic infections caused by multidrug-resistant (MDR) bacteria, therefore it is important to design and develop novel strategies to tackle this problems. Among various novel strategies, Structurally Nanoengineered Antimicrobial Peptide Polymers (SNAPPs) have been introduced in recent years to overcome this global health care issue and they are found to be more efficient in their performance. Many facile methods are adapted to synthesize complex SNAPPs with required dimensions and unique functionalities. Their unique characteristics and remarkable properties have been exploited for their immense applications in various fields including biomedicine, targeting therapies, gene delivery, bioimaging, and many more. This review article deals with its background, design, synthesis, mechanism of action, and wider applications in various fields of SNAPPs. Graphic abstract

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Simulated Clustering Dynamics of Colloidal Magnetic Nanoparticles

Nanoscale ◽

10.1039/d0nr08561h ◽

2021 ◽

Author(s):

Frederik Laust Durhuus ◽

Lau Halkier Wandall ◽

Mathias Hoeg Boisen ◽

Mathias Kure ◽

Marco Beleggia ◽

...

Keyword(s):

Magnetic Nanoparticles ◽

Self Assembly ◽

Biomedical Applications ◽

Magnetic Nanoparticle ◽

Bottom Up ◽

Novel Materials ◽

Nanoparticle Clusters ◽

Clustering Dynamics

Magnetically guided self-assembly of nanoparticles is a promising bottom-up method to fabricate novel materials and superstructures, such as, for example, magnetic nanoparticle clusters for biomedical applications. The existence of assembled...

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Magnetic nanoparticles: biomedical applications and challenges

Journal of Materials Chemistry ◽

10.1039/c0jm00994f ◽

2010 ◽

Vol 20 (40) ◽

pp. 8760 ◽

Cited By ~ 223

Author(s):

Nhiem Tran ◽

Thomas J. Webster

Keyword(s):

Magnetic Nanoparticles ◽

Biomedical Applications

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Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept

Materials ◽

10.3390/ma14154300 ◽

2021 ◽

Vol 14 (15) ◽

pp. 4300

Author(s):

Marta Multigner ◽

Irene Morales ◽

Marta Muñoz ◽

Victoria Bonache ◽

Fernando Giacomone ◽

...

Keyword(s):

Mechanical Properties ◽

Magnetic Nanoparticles ◽

Electromagnetic Fields ◽

Biomedical Applications ◽

Infrared Camera ◽

Proof Of Concept ◽

Scanning Calorimetry ◽

Radiofrequency Electromagnetic Fields ◽

Degradation Properties ◽

Heat Released

To modulate the properties of degradable implants from outside of the human body represents a major challenge in the field of biomaterials. Polylactic acid is one of the most used polymers in biomedical applications, but it tends to lose its mechanical properties too quickly during degradation. In the present study, a way to reinforce poly-L lactic acid (PLLA) with magnetic nanoparticles (MNPs) that have the capacity to heat under radiofrequency electromagnetic fields (EMF) is proposed. As mechanical and degradation properties are related to the crystallinity of PLLA, the aim of the work was to explore the possibility of modifying the structure of the polymer through the heating of the reinforcing MNPs by EMF within the biological limit range f·H < 5·× 109 Am−1·s−1. Composites were prepared by dispersing MNPs under sonication in a solution of PLLA. The heat released by the MNPs was monitored by an infrared camera and changes in the polymer were analyzed with differential scanning calorimetry and nanoindentation techniques. The crystallinity, hardness, and elastic modulus of nanocomposites increase with EMF treatment.

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