Conventional and Emerging Renal Biomarkers

2019 ◽  
pp. 267-275
Author(s):  
Sue M. Ford
Keyword(s):  
Renal Biomarkers

The Clinical Utility and Assessment of Renal Biomarkers in Acute Kidney Injury After Abdominal Endovascular Aneurysm Repair. A Systematic Review

2020 ◽  
Vol 25 (44) ◽  
pp. 4695-4701 ◽  
Author(s):  
Georgios Karaolanis ◽  
Zachary F. Williams ◽  
Chris Bakoyiannis ◽  
Dimitrios Hadjis ◽  
Mitchell W. Cox ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Kidney Injury ◽  
Systematic Reviews ◽  
Clinical Utility ◽  
Binding Protein ◽  
Endovascular Aneurysm Repair ◽  
Kidney Injury ◽  
Aortic Aneurysms ◽  
Renal Biomarkers ◽  
Aneurysm Repair

: The widespread adoption of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA) is due to the obvious advantages of the procedure compared to the traditional open repair. However, these advantages have to be weighed against the increased risk of renal dysfunction with EVAR. The evaluation of the perioperative renal function after EVAR has been hampered by the lack of sensitive and specific biochemical markers of acute kidney injury (AKI). The purpose of this study was to summarize all novel renal biomarkers and to evaluate their clinical utility for the assessment of the kidney function after EVAR. A systematic review of the current literature, as the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines, was performed to identify relevant studies with novel renal biomarkers and EVAR. Pubmed and Scopus databases were systemically searched. Studies reporting on thoracic endovascular aortic repair (TEVAR), case reports, case series, letters to the editor, and systematic reviews were excluded. Neutrophil-Gelatinase-Associated Lipocalin, Cystatin C, Liver-type fatty-acid-binding protein were the most common among the eligible studies while Interleukin-18, Retinol binding protein, N-acetyle-b-D-glucosaminidase and microalbumin have a sparse appearance in the literature. These biomarkers have been assessed in plasma as well as urine samples with each sample material having its own advantages and drawbacks. Which of these biomarkers has the most potential for assessing postoperative renal failure after EVAR, remains to be proved. The few studies presented in the literature show the potential clinical utility of these biomarkers, but larger studies with longer follow-up are required to determine the precise relationship between these biomarkers and postoperative acute kidney injury.

High Prevalence of Vitamin D Deficiency and Correlation with Cystatin-C and Other Cardiovascular and Renal Risk Biomarkers in Patients with Type 2 Diabetes Mellitus Complicated with Hypertension

2020 ◽  
Vol 17 (1) ◽  
pp. 81-90
Author(s):  
Mohammad J. Alkhatatbeh ◽  
Sajedah A. Smadi ◽  
Khalid K. Abdul-Razzak ◽  
Nesreen A. Saadeh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Cystatin C ◽  
P Values ◽  
Renal Biomarkers ◽  
Risk Biomarkers

Background: Vitamin D is increasingly investigated as having a role in Type 2 Diabetes Mellitus (T2DM) and its cardiovascular and renal complications. Objective: This study aimed to investigate the association between 25-hydroxyvitamin D (25-OHD) and biomarkers of cardiovascular and renal complications, including cystatin-C. Methods: This cross-sectional study involved 117 participants with T2DM that was not complicated with cardiovascular or renal diseases except hypertension. 25-OHD was measured by electrochemiluminescence immunoassay, while cystatin-C was measured by enzyme-linked-immunosorbent-assay. Other biomarkers, including lipids, creatinine, urea and glycemic measures, were determined by the routine biochemistry assays. Results: The prevalence of vitamin D deficiency was 74.36%. There was no significant difference in cardiovascular and renal biomarkers, including glucose, HbA1c, lipids, urea, creatinine and cystatin-C between participants with adequate and deficient vitamin D (p-values>0.05). Participants with adequate vitamin D were older in age, more obese and having lower eGFR (p-values<0.05). 25-OHD was weakly correlated with age, duration of DM, urea, creatinine and inversely correlated with eGFR (rvalues< 0.32, p-values<0.05). Although creatinine and cystatin-C were directly correlated (r=0.42, pvalue< 0.001), cystatin-C and 25-OHD were not correlated (p-value>0.05). Hypertensive participants were more obese, having a longer duration of DM and higher urea and cystatin-C compared to nonhypertensive participants (p-values<0.05). Binary logistic regression analysis revealed that hypertension could be predicted from increased BMI. Conclusion: 25-OHD was not found to be correlated with cardiovascular risk biomarkers, but it was correlated with renal biomarkers, including urea, creatinine and eGFR. Cystatin-C and 25-OHD were not observed to be correlated to each other, but both were correlated to renal function. Obesity was a significant predictor of hypertension.

Renal biomarkers for assessment of kidney function in renal transplant recipients: how do they compare?

2012 ◽  
Vol 44 (6) ◽  
pp. 1871-1876 ◽  
Author(s):  
Samra Abouchacra ◽  
Ahmed Chaaban ◽  
Raafat Hakim ◽  
Nicole Gebran ◽  
Hanan El-Jack ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Kidney Function ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Renal Biomarkers

Diet quality and diet patterns in relation to circulating renal biomarkers in uninephrectomized rats

2018 ◽  
Vol 27 (5) ◽  
pp. 1289-1295
Author(s):  
Nadia A. Mohamed ◽  
Fatma Farag Abdel Hamid ◽  
Dawoud Fakhary Habib ◽  
Aly Mohamed Ezz El-Arab ◽  
Rehab A. Mohamed
Keyword(s):  
Diet Quality ◽  
Diet Patterns ◽  
Renal Biomarkers

scholarly journals Current and novel renal biomarkers in heart failure

2011 ◽  
Vol 17 (2) ◽  
pp. 241-250 ◽  
Author(s):  
Kevin Damman ◽  
Adriaan A. Voors ◽  
Gerjan Navis ◽  
Dirk J. van Veldhuisen ◽  
Hans L. Hillege
Keyword(s):  
Heart Failure ◽  
Renal Biomarkers

scholarly journals Evaluation of Novel Urinary Renal Biomarkers: Biological Variation and Reference Change Values

2012 ◽  
Vol 40 (3) ◽  
pp. 541-549 ◽  
Author(s):  
Mark D. Pinches ◽  
Catherine J. Betts ◽  
Susan J. Bickerton ◽  
Laura Beattie ◽  
Lisa D. Burdett ◽  
...  
Keyword(s):  
Biological Variation ◽  
Renal Biomarkers

Potential Renal Biomarkers in Experimental Left Ventricular Dysfunction

2010 ◽  
Vol 16 (8) ◽  
pp. S30
Author(s):  
Fernando L. Martin ◽  
Brenda K. Huntley ◽  
Paul M. McKie ◽  
S. Jeson Sangaralingham ◽  
Tomoko Ichiki ◽  
...  
Keyword(s):  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Renal Biomarkers

scholarly journals Renal Biomarkers: Review

2016 ◽  
Author(s):  
Hüseyin Koçan ◽  
Şiir Yıldırım ◽  
Enver Özdemir
Keyword(s):  
Renal Biomarkers

scholarly journals Is there a protective effect with remote ischemic preconditioning on contrast-induced acute renal injury after coronary angiography in low-risk patients?

2018 ◽  
Vol 8 (4) ◽  
pp. 38-38
Author(s):  
Sanaz Soleymani ◽  
Hamid Reza Samimagham ◽  
Mohammad Tamaddondar ◽  
Hossein Farshidi ◽  
Mahmood Khayatian ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Serum Creatinine ◽  
Protective Effect ◽  
Ischemic Preconditioning ◽  
Low Risk ◽  
Remote Ischemic Preconditioning ◽  
Control Group ◽  
Renal Biomarkers ◽  
Significant Difference ◽  
Risk Patients

Introduction: Contrast-induced acute kidney injury (CIN-AKI) is a serious complication of coronary angiography. Given the weaknesses in the common protective methods used to prevent CIN-AKI, a safe and effective strategy is needed. RIPC has been shown to have a nephroprotective effect. Objectives: We aimed to determine the protective effect of RIPC on CIN-AKI after angiography or percutaneous coronary intervention (PCI) in low-risk patients. Patients and Methods: In our study, 140 low-risk patients who needed angiography or PCI, were assigned to either RIPC or control group. In each group, serum creatinine and urinary neutrophil gelatinaseassociated lipocalin (uNGAL) were measured before the procedure. Serum creatinine was measured daily for 2 days and uNGAL was measured 6 and 24 hours after the procedure. Diagnosis of AKI was, according to the Kidney Disease; Improving Global Outcomes (KDIGO) criteria (2012). Results: The mean age in the remote ischemic preconditioning (RIPC) group was 56.8 ± 11.4 years and 56.3 ± 11.8 years in the control group. We observed no significant difference regarding patient’s characteristic and renal biomarkers at baseline. There was no significant difference in the incidence of AKI (P = 0.116). The uNGAL increased by 36.2% 6-hour after the procedure in patients with AKI, while at the same time, this biomarker increased only by 4.3% in patients without AKI. Conclusion: We concluded that RIPC, with 3 cycles of 5-minute ischemia and 5-minute reperfusion, did not decrease CIN-AKI or altering renal biomarkers course in low-risk patients undergoing coronary angiography or PCI. Additionally, uNGAL, seems to be an appropriate biomarker for early diagnosis of CIN-AKI, 6 hours after contrast media exposure.

scholarly journals Pre-Eclampsia: Epidemiology and Renal Biomarkers at Brazzaville University Hospital

2020 ◽  
Author(s):  
Lethso Thibaut Ocko Gokaba ◽  
Jeanne Gambomi Kibah ◽  
Gauthier Buambo ◽  
Clautaire Itoua ◽  
Gaetan Ngakosso ◽  
...  
Keyword(s):  
University Hospital ◽  
Renal Biomarkers
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