Iron Homeostasis in Cyanobacteria

Cyanobacteria ◽  
2019 ◽  
pp. 245-260 ◽  
Author(s):  
Manish Singh Kaushik ◽  
Meenakshi Srivastava ◽  
Arun Kumar Mishra
Keyword(s):  
Iron Homeostasis

Age and gender dependent differences in BMP6 mediated hepcidin expression and iron homeostasis

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
S Arndt ◽  
U Mägdefrau ◽  
C Dorn ◽  
K Schardt ◽  
C Hellerbrand ◽  
...  
Keyword(s):  
Iron Homeostasis ◽  
Age And Gender ◽  
Hepcidin Expression ◽  
And Gender

Meeting Report: Intestinal BMP6, a Master Gene for the Regulation of Iron Homeostasis

2011 ◽  
Vol 49 (10) ◽  
Author(s):  
Stephanie Arndt ◽  
Ulrike Maegdefrau ◽  
Christoph Dorn ◽  
Katharina Schardt ◽  
Claus Hellerbrand ◽  
...  
Keyword(s):  
Iron Homeostasis ◽  
Meeting Report

In vivo Experiments of Natural Products Protection of Antagonistic Effects of Lead on Iron

2018 ◽  
Vol 68 (12) ◽  
pp. 2747-2751
Author(s):  
Marioara Nicula ◽  
Nicolae Pacala ◽  
Lavinia Stef ◽  
Ioan Pet ◽  
Dorel Dronca ◽  
...  
Keyword(s):  
Aquatic Environment ◽  
Iron Homeostasis ◽  
Iron Concentration ◽  
Antagonistic Effect ◽  
Tissue Samples ◽  
Antagonistic Effects ◽  
In Vivo Experiments ◽  
Living Organisms ◽  
Toxic Potential

Living organisms take nutrients from the environment, and together with them, substances with toxic potential � such as heavy metals. Lead is one common metal pollutant especially in aquatic environment, from where the fish can be intoxicated very easily. Bioavailability, distribution, toxic action, synergistic and antagonistic effects are characteristics which can alter the fish health. Our experimental study followed the effects of lead overload in water on iron distribution, in different tissues sample Carassius gibelio Bloch fish. We performed the experiment in four different fish groups: control C; lead � Pb (administration of lead in water 0.075mg/mL of water, as Pb(NO3)2 x � H2O); lead (the same dose) and 2% of freeze-dry garlic incorporated into fishes� food � Pb+garlic; lead (the same dose) and 2% chlorella incorporated into fishes� food � Pb+chlorella, for 21 consecutive days. The iron concentration was analysed with AAS (Atomic Absorption Spectroscopy) from gills, muscle, skin (and scales), intestine, liver, heart, brain, ovary, testicles, and kidney. The obtained data presented a significantly decrease of iron content in all tested tissue samples that demonstrated, alteration of iron homeostasis, explained by a strong antagonistic effect of lead on iron. Our experiment showed that biologic active principles from garlic and chlorella act like natural protectors, and potentiate the iron deficiency even in the case of lead overload in aquatic environment, for fish.

Cellular Iron Homeostasis and Therapeutic Implications of Iron Chelators in Cancer

2014 ◽  
Vol 15 (12) ◽  
pp. 1125-1140 ◽  
Author(s):  
Mohsin Raza ◽  
Sankalpa Chakraborty ◽  
Monjoy Choudhury ◽  
Prahlad Ghosh ◽  
Alo Nag
Keyword(s):  
Iron Homeostasis ◽  
Iron Chelators ◽  
Therapeutic Implications ◽  
Cellular Iron ◽  
Cellular Iron Homeostasis

Treponema, Iron and Neurodegeneration

2018 ◽  
Vol 15 (8) ◽  
pp. 716-722 ◽  
Author(s):  
A. Jolivet-Gougeon ◽  
M. Bonnaure-Mallet
Keyword(s):  
Iron Metabolism ◽  
Plasma Proteins ◽  
Iron Homeostasis ◽  
Neurological Diseases ◽  
Host Cells ◽  
Loss Of Function ◽  
Binding Ability ◽  
Iron Binding Proteins ◽  
Oxidative Species ◽  
Iron Reductase

Spirochetes are suspected to be linked to the genesis of neurological diseases, including neurosyphillis or neurodegeneration (ND). Impaired iron homeostasis has been implicated in loss of function in several enzymes requiring iron as a cofactor, formation of toxic oxidative species, inflammation and elevated production of beta-amyloid proteins. This review proposes to discuss the link that may exist between the involvement of Treponema spp. in the genesis or worsening of ND, and iron dyshomeostasis. Proteins secreted by Treponema can act directly on iron metabolism, with hemin binding ability (HbpA and HbpB) and iron reductase able to reduce the central ferric iron of hemin, iron-containing proteins (rubredoxin, neelaredoxin, desulfoferrodoxin metalloproteins, bacterioferritins etc). Treponema can also interact with cellular compounds, especially plasma proteins involved in iron metabolism, contributing to the virulence of the syphilis spirochetes (e.g. treponemal motility and survival). Fibronectin, transferrin and lactoferrin were also shown to be receptors for treponemal adherence to host cells and extracellular matrix. Association between Treponema and iron binding proteins results in iron accumulation and sequestration by Treponema from host macromolecules during systemic and mucosal infections.

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