Bimolecular-conjugated nanoparticles (NP) demonstrate unique properties with wide-ranging
applications in the diagnosis of infectious diseases as well as application in gene therapy and drug
delivery therapies. The unique properties and utility of NP arise from a variety of attributes, including
the similar size of nanoparticles and biomolecules. Biological functions depend primarily on units that
have nanoscale dimensions, such as viruses, ribosomes, molecular motors and components of the
extra cellular matrix. In addition, engineered devices at the nanoscale are small enough to interact
directly with sub-cellular compartments and to probe intracellular events. This review focuses on the
methods of nanoparticle interaction with different biomolecules such as antibodies, DNA, lipids, and
proteins. More specifically, there is discussion about bioconjugation linkage and a summary of
potential biomedical applications of bio-conjugated nanoparticles as targeted drug delivery vehicles.
Targeted drug delivery to the peripheral nervous system using gene therapy
