Exploitation of P-glycoprotein Over-expression for Targeted Drug Delivery to Breast Cancer

2011 ◽  
Author(s):  
David Putnam
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Over Expression ◽  
P Glycoprotein ◽  
Targeted Drug

Identification of protein targets and the mechanism of the cytotoxic action of Ipomoea turpethum extract loaded nanoparticles against breast cancer cells

2019 ◽  
Vol 7 (39) ◽  
pp. 6048-6063 ◽  
Author(s):  
Mohd Mughees ◽  
Mohd Samim ◽  
Yadhu Sharma ◽  
Saima Wajid
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Breast Cancer Cells ◽  
Cytotoxic Action ◽  
Protein Targets ◽  
Targeted Drug

The shortcomings of the currently available anti-breast cancer agents compel the development of the safer targeted drug delivery for the treatment of breast cancer.

ROS-Switchable Polymeric Nanoplatform with Stimuli-Responsive Release for Active Targeted Drug Delivery to Breast Cancer

2017 ◽  
Vol 9 (14) ◽  
pp. 12227-12240 ◽  
Author(s):  
Yu Zhang ◽  
Qin Guo ◽  
Sai An ◽  
Yifei Lu ◽  
Jianfeng Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Stimuli Responsive ◽  
Targeted Drug

Overcoming multidrug resistance by a combination of chemotherapy and photothermal therapy mediated by carbon nanohorns

2016 ◽  
Vol 4 (36) ◽  
pp. 6043-6051 ◽  
Author(s):  
Junling Wang ◽  
Ran Wang ◽  
Fangrong Zhang ◽  
Yajun Yin ◽  
Leixia Mei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multidrug Resistance ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Carbon Nanohorns ◽  
P Glycoprotein ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

A targeted drug delivery system based on carbon nanohorns for targeting P-glycoprotein and delivering etoposide into cells to overcome multidrug resistance.

scholarly journals Targeted Drug Delivery Systems Mediated by a Novel Peptide in Breast Cancer Therapy and Imaging

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66128 ◽  
Author(s):  
Ruei-Min Lu ◽  
Min-Shan Chen ◽  
De-Kuan Chang ◽  
Chien-Yu Chiu ◽  
Wei-Chuan Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Breast Cancer Therapy ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Synthesis of a novel, sequentially active-targeted drug delivery nanoplatform for breast cancer therapy

Biomaterials ◽  
2015 ◽  
Vol 59 ◽  
pp. 88-101 ◽  
Author(s):  
Arpan Satsangi ◽  
Sudipa S. Roy ◽  
Rajiv K. Satsangi ◽  
Anthony W. Tolcher ◽  
Ratna K. Vadlamudi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Breast Cancer Therapy ◽  
Targeted Drug

A Review on Targeting Nanoparticles for Breast Cancer

2019 ◽  
Vol 20 (13) ◽  
pp. 1087-1107 ◽  
Author(s):  
Hasanain Gomhor J. Alqaraghuli ◽  
Soheila Kashanian ◽  
Ronak Rafipour
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Targeted Drug Delivery ◽  
Breast Cancer Cells ◽  
Pharmaceutical Research ◽  
Chemotherapeutic Agents ◽  
Great Promise ◽  
Targeted Drug

Chemotherapeutic agents have been used extensively in breast cancer remedy. However, most anticancer drugs cannot differentiate between cancer cells and normal cells, leading to toxic side effects. Also, the resulted drug resistance during chemotherapy reduces treatment efficacy. The development of targeted drug delivery offers great promise in breast cancer treatment both in clinical applications and in pharmaceutical research. Conjugation of nanocarriers with targeting ligands is an effective therapeutic strategy to treat cancer diseases. In this review, we focus on active targeting methods for breast cancer cells through the use of chemical ligands such as antibodies, peptides, aptamers, vitamins, hormones, and carbohydrates. Also, this review covers all information related to these targeting ligands, such as their subtypes, advantages, disadvantages, chemical modification methods with nanoparticles and recent published studies (from 2015 to present). We have discussed 28 different targeting methods utilized for targeted drug delivery to breast cancer cells with different nanocarriers delivering anticancer drugs to the tumors. These different targeting methods give researchers in the field of drug delivery all the information and techniques they need to develop modern drug delivery systems.

Herbal Based Polymeric Nanoparticles as a Therapeutic Remedy for Breast Cancer

2020 ◽  
Vol 20 ◽  
Author(s):  
Mohd Mughees ◽  
Saima Wajid
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Herbal Extract ◽  
Future Research ◽  
Delivery Methods ◽  
Cancer Breast ◽  
Conventional Drug ◽  
Targeted Drug

Background: The currently available anti breast cancer agents as well as conventional drug delivery methods have some limitations. Objective: In view of these limitations, researchers used phytochemicals/herbal extracts as anti-breast cancer agents together with the polymeric nanoparticles to provide an effective way of targeted drug delivery with lesser /no side effects. Methods: The literature for this review was searched during the year 2014 to 2018 by using the keywords, ‘ ‘breast cancer’, ‘breast cancer and its current treatments’, ‘plants against the breast cancer’, ‘polymeric nanoparticles’, ‘herbal based polymeric nanoparticles’. The databases i.e. PubMed, Science Direct and Google Scholar were used for collecting the information. Results: In the present review, we try to summarize the potential of herbal based nanoformulation as specific and high efficacy therapeutic strategy in order to pave a way for the future research involving screening and use of herbal nanoparticles for the treatment of breast cancer. Conclusion: The encapsulation of the herbal extract in the polymeric nanoparticles is the prominent, effective and emerging way of targeted drug delivery for cancer. It may serve as safer way of targeted drug delivery and may be the answer of the complications related to the currently available anti-breast cancer agents as well as limitations of conventional method of drug delivery.

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