Local ventilation

Author(s):  
Zhixiang Cao ◽  
Yu Zhou ◽  
Shijie Cao ◽  
Yi Wang
Keyword(s):  
2013 ◽  
Vol 12 (3) ◽  
pp. 135-144 ◽  
Author(s):  
Erik R. Swenson

Hypoxic vasoconstriction in the lung is a unique and fundamental characteristic of the pulmonary circulation. It functions in health and disease states to better preserve ventilation-perfusion matching by diverting blood flow to better ventilated regions when local ventilation is compromised. As more areas of lung become hypoxic either with high altitude or global lung disease, then hypoxic pulmonary vasoconstriction (HPV) becomes less effective in ventilation-perfusion matching and can lead to pulmonary hypertension. HPV is intrinsic to the vascular smooth muscle and its mechanisms remain poorly understood. In addition, the pulmonary vascular endothelium, red cells, lung innervation, and numerous circulating vasoactive agents also affect the strength of HPV. This review will discuss the pathophysiology of HPV and address its role in pulmonary hypertension associated with World Health Organization Group 3 diseases. When sustained beyond many hours, HPV may initiate pulmonary vascular remodeling and lead to more fixed and less oxygen-responsive pulmonary hypertension if the hypoxic stimulus is maintained.


Author(s):  
Dhaval Desai ◽  
Jiang Zhou

In a world where the increasing demand on developing energy-efficient systems is probably the most stringent design constraint, the trend in engineering research in recent years has been to optimize the existing technologies rather than to implement new ones. The present work addresses a robust axial-type fan design technique developed using an optimization technique. A fan is indispensable equipment for primary and local ventilation in mining industries. We always pursue the fan with high working efficiency and low noise. In this paper, an optimization method is developed to improve the pneumatic properties of the fan based on the blade element theory. A new type of fan used in local ventilation is designed with the help of computer. It is shown that the new design enhanced the efficient up to 88%. Numerical analysis is also conducted to validate the optimization design results.


1990 ◽  
Vol 106 (12) ◽  
pp. 725-729 ◽  
Author(s):  
Sohei SHIMADA ◽  
Shoji OHMURA

2021 ◽  
pp. 103491
Author(s):  
Jia-Ning Fan ◽  
Yang Yang ◽  
Yi Wang ◽  
Yuming Zhang ◽  
Yingrong Wei ◽  
...  

1991 ◽  
Vol 70 (6) ◽  
pp. 2514-2521 ◽  
Author(s):  
A. Kaise ◽  
A. N. Freed ◽  
W. Mitzner

In the present study, we investigated the interaction between CO2 concentration and rate of delivered flow on peripheral airway resistance (Rp) in the intact canine lung. Dogs were anesthetized, intubated, paralyzed, and mechanically ventilated with room air to maintain end-tidal CO2 between 4.8 and 5.2%. Using a wedged bronchoscope technique, we measured Rp at functional residual capacity. The relationship between CO2 concentration and Rp was measured at flow rates of 100 and 400 ml/min with 5, 3, 2, 1, and 0% CO2 in air. Measurements were made at the end of a 3-min exposure to each gas. At low flow rates (100 ml/min) responses to hypocapnia were small, whereas at high flow rates (400 ml/min) responses were large. The PC50 (defined as the CO2 concentration required to produce a 50% increase in Rp above baseline Rp established on 5% CO2) at 400 ml/min (1.73%) was significantly larger than that at 100 ml/min (0.38%). We also directly measured the relationship between Rp and flow rate with 5% CO2 (normocapnia) or 1% CO2 (hypocapnia) delivered into the wedged segment. Increases in normocapnic flow caused small but significant decreases in Rp. In contrast, increases in hypocapnic flow from 100 to 400 ml/min caused a 108% increase in Rp. Thus the response to hypocapnia is augmented by increasing flow rate. This interaction can be explained by a simple model that considers the effect of local ventilation-perfusion ratio and gas mixing on the local CO2 concentration at the site of peripheral airway contraction.


Atmosphere ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 33 ◽  
Author(s):  
Yunlong Peng ◽  
Zhi Gao ◽  
Riccardo Buccolieri ◽  
Wowo Ding

Urban outdoor ventilation and pollutant dispersion have important implications for urban design and planning. In this paper, two urban morphology parameters, i.e. the floor area ratio (FAR) and the building site coverage (BSC), are considered to investigate their quantitative correlation with urban ventilation indices. An idealized model, including nine basic units with FAR equal to 5, is considered and the BSC is increased from 11% to 77%, generating 101 non-repetitive asymmetric configurations, with attention to the influence of plan density, volume ratio, and building layout on ventilation performance within urban plot areas. Computational Fluid Dynamics (CFD) simulations are used to assess the ventilation efficiency at pedestrian level (2m above the ground) within each model central area. Six indices, including the air flow rate (Q), the mean age of air (τP), the net escape velocity (NEV), the purging flow rate (PFR), the visitation frequency (VF), and the resident time (TP) are used to assess the local ventilation performance. Results clearly show that, fixing the FAR, the local ventilation performance is not linearly related to BSC, but it also depends on buildings arrangement. Specifically, as the BSC increases, the ventilation in the central area does not keep reducing. On the contrary, some forms with low BSC have poor ventilation and some particular configurations with high BSC have better ventilation, which indicates that not all high-density configurations experience poor ventilation. The local ventilation performance can be effectively improved by rationally arranging the buildings. Even though the application of these results to real cities requires further research, the present findings suggest a preliminary way to build up a correlation between urban morphology parameters and ventilation efficiency tailored to develop a feasible framework for urban designers.


Sign in / Sign up

Export Citation Format

Share Document