Antiinflammatory effects of turmeric (Curcuma longa) and ginger (Zingiber officinale)

Los aceites esenciales son compuestos orgánicos importantes en el sector farmacéutico debido a sus propiedades antimicrobianas, volviéndose una alternativa de solución para determinadas fitopatologías. En el presente estudio se evaluó in vitro la actividad inhibitoria de aceites esenciales de Curcuma longa y Zingiber officinale contra Colletotrichum sp. obtenidas a partir de cultivos de Dioscorea rotundata en Toluviejo (Sucre, Colombia). Concentraciones de 3,000; 5,000; 8,000 y 10,000 mg/L de extracciones de aceite (método de hidrodestilación asistida por microondas) fueron aplicados a cultivos in vitro del hongo. Además, se empleó un testigo absoluto y controles positivo y negativo. Los aceites fueron caracterizados por cromatografía de gases acoplado a espectrometría de masa. La actividad inhibitoria se realizó por medio de la prueba de siembra en superficie (porcentaje de índice de inhibición). Los mayores valores de índice antifúngico se observaron a 10,000 mg/L similar al obtenido con el control positivo por benomil. De la caracterización química de los aceites esenciales el metabolito secundario que se presentó con mayor rango fue el monoterpeno 3-Thujeno y el citral. Los aceites esenciales de C. longa y Z. officinale generaron actividad inhibitoria contra el crecimiento de Colletotrichum sp., y por lo tanto pueden ser empleados para reducir la antracnosis.

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Extraction of selected prohealth substances from Curcuma longa and Zingiber officinale in artificial digestive juices

Journal of the Science of Food and Agriculture ◽

10.1002/jsfa.11575 ◽

2021 ◽

Author(s):

Agata Krakowska ◽

Katarzyna Kała ◽

Bartłomiej Rospond ◽

Agnieszka Szewczyk ◽

Włodzimierz Opoka ◽

...

Keyword(s):

Curcuma Longa ◽

Zingiber Officinale

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WS-5 Extract of Curcuma longa, Chaenomeles sinensis, and Zingiber officinale Contains Anti-AChE Compounds and Improves β-Amyloid-Induced Memory Impairment in Mice

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/5160293 ◽

2019 ◽

Vol 2019 ◽

pp. 1-16 ◽

Cited By ~ 2

Author(s):

Ju Eun Kim ◽

Abinash Chandra Shrestha ◽

Hyo Shin Kim ◽

Ha Neul Ham ◽

Jun Hyeong Kim ◽

...

Keyword(s):

Memory Impairment ◽

Antioxidant Activities ◽

Curcuma Longa ◽

Senile Plaques ◽

Total Antioxidant Status ◽

Ethanol Extract ◽

Zingiber Officinale ◽

Chaenomeles Sinensis

Alzheimer's disease (AD) is linked to an extensive neuron loss via accumulation of amyloid-beta (Aβ) as senile plaques associated with reactive astrocytes and microglial activation in the brain. The objective of this study was to assess the therapeutic effect of WS-5 ethanol extract in vitro and in vivo against Aβ-induced AD in mice and to identify the extract’s active constituents. In the present study, WS-5 exerted a significant inhibitory effect on acetylcholinesterase (AChE). Analysis by transmission electron microscopy (TEM) revealed that WS-5 prevented Aβ oligomerization via inhibition of Aβ1-42 aggregation. Evaluation of antioxidant activities using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) demonstrated that WS-5 possessed a high antioxidant activity, which was confirmed by measuring the total antioxidant status (TAS). Furthermore, the anti-inflammatory properties of WS-5 were examined using lipopolysaccharide-stimulated BV-2 microglial cells. WS-5 significantly inhibited the lipopolysaccharide–induced production of nitric oxide and two proinflammatory cytokines, TNF-α and IL-6. The memory impairment in mice with Aβ-induced AD was studied using the Morris water maze and passive avoidance test. Immunohistochemistry was performed to monitor pathological changes in the hippocampus and cortex region of the mouse brain. The animal study showed that WS-5 (250 mg/kg) treatment improved learning and suppressed memory impairment as well as reduced Aβ plaque accumulation in Aβ-induced AD. HPLC analysis identified the extract’s active compounds that exert anti-AChE activity. In summary, our findings suggest that WS-5 could be applied as a natural product therapy with a focus on neuroinflammation-related neurodegenerative disorders.

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Ethnopharmacological Assessment of Medicinal Plants Used against Livestock Infections by the People Living around Indus River

BioMed Research International ◽

10.1155/2014/616858 ◽

2014 ◽

Vol 2014 ◽

pp. 1-14 ◽

Cited By ~ 8

Author(s):

Sakina Mussarat ◽

Rahila Amber ◽

Akash Tariq ◽

Muhammad Adnan ◽

Naser M. AbdElsalam ◽

...

Keyword(s):

Medicinal Plants ◽

Curcuma Longa ◽

Zingiber Officinale ◽

Punica Granatum ◽

Preference Ranking ◽

Conservation Strategies ◽

Melia Azedarach ◽

Withania Coagulans ◽

The People ◽

Preferred Species

The present study was aimed to document detailed ethnopharmacological knowledge of medicinal plants against livestock infections of an unexplored remote region of Pakistan. Semistructured questionnaires were used for data collection. Total 43 plants belonging to 26 families were found to be used in ethnoveterinary practices. Seeds (29%) were found to be the most frequent plant part used followed by leaves (22%). Ethnoveterinary recipes were mostly prepared in the form of decoction and powdering. Informant consensus factor (Fic) results revealed high consensus for gastrointestinal (0.81), mastitis (0.82), and dermatological infections (0.80).Curcuma longaranked first with highest fidelity level (FL) value (66%) followed byTrachyspermum ammithat ranked second (58%). Preference ranking (PR) results showed thatZingiber officinale,Punica granatum,Triticum aestivum,Gossypium hirsutum, andWithania coagulanswere the most preferred species for the treatment of diarrhea. Direct matrix ranking (DMR) results showed thatMorus alba,Melia azedarach,Withania coagulans,Cassia fistula,Azadirachta indica, andTamarix aphyllawere the multipurpose species of the region. We invite the attention of pharmacologists and chemists for further exploration of plants having high Fic, FL, and PR values in the present study. Conservation strategies should be adopted for the protection of multipurpose plant species.

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