Bioactive compounds from Punica granatum, Curcuma longa and Zingiber officinale and their therapeutic potential

2008 ◽  
Vol 33 (4) ◽  
pp. 329 ◽  
Author(s):  
I. Ahmad ◽  
M. Zahin ◽  
F. Aqil ◽  
S. Hasan ◽  
M.S.A. Khan ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Curcuma Longa ◽  
Zingiber Officinale ◽  
Punica Granatum

Anti-giardial therapeutic potential of dichloromethane extracts of Zingiber officinale and Curcuma longa in vitro and in vivo

2016 ◽  
Vol 115 (7) ◽  
pp. 2637-2645 ◽  
Author(s):  
Ahmad K. Dyab ◽  
Doaa A. Yones ◽  
Zedan Z. Ibraheim ◽  
Tasneem M. Hassan
Keyword(s):  
Therapeutic Potential ◽  
Curcuma Longa ◽  
Zingiber Officinale

scholarly journals Ethnopharmacological Assessment of Medicinal Plants Used against Livestock Infections by the People Living around Indus River

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Sakina Mussarat ◽  
Rahila Amber ◽  
Akash Tariq ◽  
Muhammad Adnan ◽  
Naser M. AbdElsalam ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Curcuma Longa ◽  
Zingiber Officinale ◽  
Punica Granatum ◽  
Preference Ranking ◽  
Conservation Strategies ◽  
Melia Azedarach ◽  
Withania Coagulans ◽  
The People ◽  
Preferred Species

The present study was aimed to document detailed ethnopharmacological knowledge of medicinal plants against livestock infections of an unexplored remote region of Pakistan. Semistructured questionnaires were used for data collection. Total 43 plants belonging to 26 families were found to be used in ethnoveterinary practices. Seeds (29%) were found to be the most frequent plant part used followed by leaves (22%). Ethnoveterinary recipes were mostly prepared in the form of decoction and powdering. Informant consensus factor (Fic) results revealed high consensus for gastrointestinal (0.81), mastitis (0.82), and dermatological infections (0.80).Curcuma longaranked first with highest fidelity level (FL) value (66%) followed byTrachyspermum ammithat ranked second (58%). Preference ranking (PR) results showed thatZingiber officinale,Punica granatum,Triticum aestivum,Gossypium hirsutum, andWithania coagulanswere the most preferred species for the treatment of diarrhea. Direct matrix ranking (DMR) results showed thatMorus alba,Melia azedarach,Withania coagulans,Cassia fistula,Azadirachta indica, andTamarix aphyllawere the multipurpose species of the region. We invite the attention of pharmacologists and chemists for further exploration of plants having high Fic, FL, and PR values in the present study. Conservation strategies should be adopted for the protection of multipurpose plant species.

Natural Products and their Promise against COVID 19: Review

2021 ◽  
Vol 17 ◽  
Author(s):  
Fatma Abo-Elghiet ◽  
Hanan M. Alharbi ◽  
Abeer Temraz
Keyword(s):  
Respiratory Infections ◽  
Nigella Sativa ◽  
Curcuma Longa ◽  
Zingiber Officinale ◽  
Punica Granatum ◽  
Echinacea Purpurea ◽  
In Vivo Studies ◽  
Traditional Treatment ◽  
Global Health Problem

Background: Since the beginning of medical history, plants have been exemplary sources of a variety of pharmacological compounds that are still used in modern medication. Respiratory infections are a serious and persistent global health problem, most acute and chronic respiratory infections are caused by viruses, whose ability to rapidly mutate may result in epidemics and pandemics, as seen recently with MERS-COV (2012) and SARS-COV-2 (2019), the latter causing coronavirus disease 2019 (COVID-19). Methods: Highlight the tremendous benefits of plants that have been widely used as dietary supplements or traditional treatment for various respiratory infections, with a focus on the most effective constituents and studies that revealed their activities against COVID-19. Results: Several traditional plants and their phytoconstituents have shown activity against respiratory viruses, including SARS-COV-2. The presented plants are Nigella sativa, Punica granatum, Panax ginseng, Withania somnifera, Glycyrrhiza glabra, Curcuma longa, Zingiber officinale, Camellia sinensis, Echinacea purpurea, Strobilanthes cusia, Stephania tetrandra, and genus Sambucus. Conclusion: The data discussed in this review can encourage carrying out in-vivo studies that may help to the discovery of herbal leads that can be feasibly used to alleviate, prevent or treat COVID-19 infection.

scholarly journals In Silico Targeting DENV2's Prefusion Envelope Protein by Several Natural Products' Bioactive Compounds

2021 ◽  
Vol 20 (3) ◽  
Author(s):  
Arief Hidayatullah ◽  
Wira Eka Putra ◽  
Sustiprijatno ◽  
Galuh Wening Permatasari ◽  
Wa Ode Salma ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Envelope Protein ◽  
In Silico ◽  
Curcuma Longa ◽  
Zingiber Officinale ◽  
Viral Fusion ◽  
Tropical Regions ◽  
Kaempferia Galanga ◽  
Protein Dimer ◽  
Severe Health Problem

Dengue caused by the dengue virus (DENV) is a severe health problem in tropical regions such as Southeast Asia, especially Indonesia. Indonesian have used rhizome as traditional medicine for 1300 years. This study investigated the compounds from Kaempferia galanga, Curcuma longa, Zingiber officinale, Curcuma aeruginosa, Curcuma zanthorrhiza, Alpinia galanga, and Allium sativum as antivirals agents, explicitly targeting the DENV envelope protein to inhibit viral fusion. This study involved 121 bioactive compounds and DENV2's prefusion envelope protein. The virtual screening and molecular docking were done through occupied the Lipinski rule of five checker (http://www.scfbio-iitd.res.in/software/drugdesign/lipinski.jsp) and AutoDock Vina (https://pyrx.sourceforge.io/) respectively. The top nine compounds with the strongest binding affinity were galangin, kampferide, demetoxy curcumin, bisdemethoxycurcumin, β-selinene, 6-(hydroxymethyl)-1,4,4-trimethylbicyclo[3.1.0]hexan-2-ol, piperine, estra-1,3, 5(10)-trien-17β-ol, and curcumin. These compounds' affinity values were significantly lower, around 45-62%, than chloroquine. Most of them interact with the kl hairpin and hydrophobic pocket formed by residues Val130, Leu135, Phe193, Leu198, and Phe279of critical domains that can interfere with the conformational change and rearrangement of protein dimer in the post-fusion stage. This study suggested that the galangin, demethoxycurcumin, and bisdemethoxycurcumin are considered the most potential compounds to be developed as anti-prefusion E DENV2 low-affinity and intense interaction with those. Keywords: DENV2, envelope protein, in silico, viral fusion, viral infection

Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances for Drug Discovery

2020 ◽  
Vol 26 ◽  
Author(s):  
Kondeti Ramudu Shanmugam ◽  
Bhasha Shanmugam ◽  
Gangigunta Venkatasubbaiah ◽  
Sahukari Ravi ◽  
Kesireddy Sathyavelu Reddy
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Diabetes Management ◽  
Therapeutic Potential ◽  
Public Health Problem ◽  
In Vivo Studies ◽  
Major Public Health Problem

Background : Diabetes is a major public health problem in the world. It affects each and every part of the human body and also leads to organ failure. Hence, great progress made in the field of herbal medicine and diabetic research. Objectives: Our review will focus on the effect of bioactive compounds of medicinal plants which are used to treat diabetes in India and other countries. Methods: Information regarding diabetes, oxidative stress, medicinal plants and bioactive compounds were collected from different search engines like Science direct, Springer, Wiley online library, Taylor and francis, Bentham Science, Pubmed and Google scholar. Data was analyzed and summarized in the review. Results and Conclusion: Anti-diabetic drugs that are in use have many side effects on vital organs like heart, liver, kidney and brain. There is an urgent need for alternative medicine to treat diabetes and their disorders. In India and other countries herbal medicine was used to treat diabetes. Many herbal plants have antidiabetic effects. The plants like ginger, phyllanthus, curcumin, aswagandha, aloe, hibiscus and curcuma showed significant anti-hyperglycemic activities in experimental models and humans. The bioactive compounds like Allicin, azadirachtin, cajanin, curcumin, querceitin, gingerol possesses anti-diabetic, antioxidant and other pharmacological properties. This review focuses on the role of bioactive compounds of medicinal plants in prevention and management of diabetes. Conclusion: Moreover, our review suggests that bioactive compounds have the potential therapeutic potential against diabetes. However, further in vitro and in vivo studies are needed to validate these findings.

scholarly journals Technologies and Extraction Methods of Polyphenolic Compounds Derived from Pomegranate (Punica granatum) Peels. A Mini Review

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 236
Author(s):  
Dimitrios Lampakis ◽  
Prodromos Skenderidis ◽  
Stefanos Leontopoulos
Keyword(s):  
Electric Fields ◽  
Bioactive Compounds ◽  
New Technologies ◽  
Ohmic Heating ◽  
Punica Granatum ◽  
Extraction Methods ◽  
Added Value ◽  
Green Solvents ◽  
Ultrasound Assisted Extraction ◽  
Functional Product

The interest in using plant by-product extracts as functional ingredients is continuously rising due to environmental and financial prospects. The development of new technologies has led to the achievement of aqueous extracts with high bioactivity that is preferable due to organic solvents nonuse. Recently, widely applied and emerging technologies, such as Simple Stirring, Pressure-Applied Extraction, Enzymatic Extraction, Ultrasound-Assisted Extraction, Pulsed Electric Fields, High Hydrostatic Pressure, Ohmic Heating, Microwave Assistant Extraction and the use of “green” solvents such as the deep eutectic solvents, have been investigated in order to contribute to the minimization of disadvantages on the extraction of bioactive compounds. This review is focused on bioactive compounds derived from pomegranate (Punica granatum) peels and highlighted the most attractive extraction methods. It is believed that these findings could be a useful tool for the pomegranate juices industry to apply an effective and economically viable extraction process, transforming a by-product to a high added value functional product.

scholarly journals Extraction of bioactive compounds from Curcuma longa L. using deep eutectic solvents: In vitro and in vivo biological activities

2021 ◽  
pp. 102697
Author(s):  
Grazielle Oliveira ◽  
Caroline Marques ◽  
Anielle de Oliveira ◽  
Amanda de Almeida dos Santos ◽  
Wanderlei do Amaral ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Curcuma Longa ◽  
Deep Eutectic Solvents

Identification and detection of bioactive compounds in turmeric (Curcuma longa L.) using gas sensor array based on molecularly imprinted polymer quartz crystal microbalance

2021 ◽  
Author(s):  
Fajar IAIN Hardoyono ◽  
Kikin Windhani
Keyword(s):  
Gas Sensor ◽  
Bioactive Compounds ◽  
Quartz Crystal Microbalance ◽  
Molecularly Imprinted Polymer ◽  
Quartz Crystal ◽  
Sensor Array ◽  
Curcuma Longa ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Gas Sensor Array

This study aimed to identify four bioactive compounds in turmeric (Curcuma longa L.) using gas sensor array based on molecularly imprinted polymer-quartz crystal microbalance (MIP-QCM). Four QCM sensors coated with...

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