Malignant hyperthermia syndrome and hydrogen sulfide signaling: Role of Kv7 channels

: There is considerable evidence in the heart that autophagy in cardiomyocytes is activated by hypoxia/reoxygenation (H/R) or in hearts by ischemia/reperfusion (I/R). Depending upon the experimental model and duration of ischemia, increases in autophagy in this setting maybe beneficial (cardioprotective) or deleterious (exacerbate I/R injury). Aside from the conundrum as to whether or not autophagy is an adaptive process, it is clearly regulated by a number of diverse molecules including reactive oxygen species (ROS), various kinases, hydrogen sulfide (H2S) and nitric oxide (NO). The purpose this review is to address briefly the controversy regarding the role of autophagy in this setting and to examine a variety of disparate molecules that are involved in its regulation.

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Taurine treatment reverses protein malnutrition-induced endothelial dysfunction of the pancreatic vasculature: the role of hydrogen sulfide

Metabolism ◽

10.1016/j.metabol.2021.154701 ◽

2021 ◽

pp. 154701

Author(s):

Daniele M. Guizoni ◽

Israelle N. Freitas ◽

Jamaira A. Victorio ◽

Isabela R. Possebom ◽

Thiago R. Araujo ◽

...

Keyword(s):

Hydrogen Sulfide ◽

Endothelial Dysfunction ◽

Protein Malnutrition ◽

Taurine Treatment

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Role of hydrogen sulfide in cerebrovascular alteration during aging

Archives of Pharmacal Research ◽

10.1007/s12272-019-01135-y ◽

2019 ◽

Vol 42 (5) ◽

pp. 446-454 ◽

Cited By ~ 1

Author(s):

Juyeon Mun ◽

Hye-Min Kang ◽

Junyang Jung ◽

Chan Park

Keyword(s):

Hydrogen Sulfide

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NaHS inhibits NF-κB signal against inflammation and oxidative stress in post-infectious irritable bowel syndrome

RSC Advances ◽

10.1039/c6ra13849g ◽

2016 ◽

Vol 6 (69) ◽

pp. 64208-64214 ◽

Cited By ~ 2

Author(s):

Shenglan Yang ◽

Danfang Deng ◽

Yingying Luo ◽

Yanran Wu ◽

Rui Zhu ◽

...

Keyword(s):

Oxidative Stress ◽

Irritable Bowel Syndrome ◽

Hydrogen Sulfide ◽

Murine Model ◽

Irritable Bowel ◽

And Oxidative Stress ◽

Post Infectious

In this study, the alleviating role of hydrogen sulfide (H2S) was investigated in a Post-Infectious Irritable Bowel Syndrome (PI-IBS) murine model and Caco-2 cells.

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Role of molybdenum in corrosion of iron-based alloys in contact with hydrogen sulfide containing solution

Materials and Corrosion ◽

10.1002/maco.201609247 ◽

2016 ◽

Vol 68 (6) ◽

pp. 595-603 ◽

Cited By ~ 4

Author(s):

G. Genchev ◽

C. Bosch ◽

E. Wanzenberg ◽

A. Erbe

Keyword(s):

Hydrogen Sulfide ◽

Iron Based ◽

Corrosion Of Iron

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Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential

Clinical Science ◽

10.1042/cs20100462 ◽

2010 ◽

Vol 120 (6) ◽

pp. 219-229 ◽

Cited By ~ 104

Author(s):

Madhav Lavu ◽

Shashi Bhushan ◽

David J. Lefer

Keyword(s):

Blood Pressure ◽

Cardiovascular Disease ◽

Hydrogen Sulfide ◽

Therapeutic Potential ◽

Blood Pressure Regulation ◽

Pressure Regulation ◽

Signalling Molecule ◽

Anti Inflammatory ◽

Antioxidant Effects

H2S (hydrogen sulfide), viewed with dread for more than 300 years, is rapidly becoming a ubiquitously present and physiologically relevant signalling molecule. Knowledge of the production and metabolism of H2S has spurred interest in delineating its functions both in physiology and pathophysiology of disease. Although its role in blood pressure regulation and interaction with NO is controversial, H2S, through its anti-apoptotic, anti-inflammatory and antioxidant effects, has demonstrated significant cardioprotection. As a result, a number of sulfide-donor drugs, including garlic-derived polysulfides, are currently being designed and investigated for the treatment of cardiovascular conditions, specifically myocardial ischaemic disease. However, huge gaps remain in our knowledge about this gasotransmitter. Only by additional studies will we understand more about the role of this intriguing molecule in the treatment of cardiovascular disease.

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