P12 Role of hydrogen sulfide in heart adaptation to physical training

Nitric Oxide ◽  
2014 ◽  
Vol 39 ◽  
pp. S19-S20
Author(s):  
Vadim Sagach ◽  
Tatiana Shimanskaya ◽  
Yulia Goshovska ◽  
Anatoliy Kotsuruba
2020 ◽  
Vol 16 ◽  
Author(s):  
Andrey Krylatov ◽  
Leonid Maslov ◽  
Sergey Y. Tsibulnikov ◽  
Nikita Voronkov ◽  
Alla Boshchenko ◽  
...  

: There is considerable evidence in the heart that autophagy in cardiomyocytes is activated by hypoxia/reoxygenation (H/R) or in hearts by ischemia/reperfusion (I/R). Depending upon the experimental model and duration of ischemia, increases in autophagy in this setting maybe beneficial (cardioprotective) or deleterious (exacerbate I/R injury). Aside from the conundrum as to whether or not autophagy is an adaptive process, it is clearly regulated by a number of diverse molecules including reactive oxygen species (ROS), various kinases, hydrogen sulfide (H2S) and nitric oxide (NO). The purpose this review is to address briefly the controversy regarding the role of autophagy in this setting and to examine a variety of disparate molecules that are involved in its regulation.


Metabolism ◽  
2021 ◽  
pp. 154701
Author(s):  
Daniele M. Guizoni ◽  
Israelle N. Freitas ◽  
Jamaira A. Victorio ◽  
Isabela R. Possebom ◽  
Thiago R. Araujo ◽  
...  

2019 ◽  
Vol 42 (5) ◽  
pp. 446-454 ◽  
Author(s):  
Juyeon Mun ◽  
Hye-Min Kang ◽  
Junyang Jung ◽  
Chan Park
Keyword(s):  

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64208-64214 ◽  
Author(s):  
Shenglan Yang ◽  
Danfang Deng ◽  
Yingying Luo ◽  
Yanran Wu ◽  
Rui Zhu ◽  
...  

In this study, the alleviating role of hydrogen sulfide (H2S) was investigated in a Post-Infectious Irritable Bowel Syndrome (PI-IBS) murine model and Caco-2 cells.


2016 ◽  
Vol 68 (6) ◽  
pp. 595-603 ◽  
Author(s):  
G. Genchev ◽  
C. Bosch ◽  
E. Wanzenberg ◽  
A. Erbe

2010 ◽  
Vol 120 (6) ◽  
pp. 219-229 ◽  
Author(s):  
Madhav Lavu ◽  
Shashi Bhushan ◽  
David J. Lefer

H2S (hydrogen sulfide), viewed with dread for more than 300 years, is rapidly becoming a ubiquitously present and physiologically relevant signalling molecule. Knowledge of the production and metabolism of H2S has spurred interest in delineating its functions both in physiology and pathophysiology of disease. Although its role in blood pressure regulation and interaction with NO is controversial, H2S, through its anti-apoptotic, anti-inflammatory and antioxidant effects, has demonstrated significant cardioprotection. As a result, a number of sulfide-donor drugs, including garlic-derived polysulfides, are currently being designed and investigated for the treatment of cardiovascular conditions, specifically myocardial ischaemic disease. However, huge gaps remain in our knowledge about this gasotransmitter. Only by additional studies will we understand more about the role of this intriguing molecule in the treatment of cardiovascular disease.


2011 ◽  
Vol 179 (2) ◽  
pp. 869-879 ◽  
Author(s):  
Guangdong Yang ◽  
Guanghua Tang ◽  
Ling Zhang ◽  
Lingyun Wu ◽  
Rui Wang

2018 ◽  
Vol 149 ◽  
pp. 1-4 ◽  
Author(s):  
Khosrow Kashfi

2006 ◽  
Vol 88 (5) ◽  
pp. 459-461
Author(s):  
DE Griffiths ◽  
R Hargrove ◽  
J Clasper

INTRODUCTION As a result of a single spinal injury seen at Frimley Park Hospital, we reviewed the injuries recorded at the Army School of Physical Training since December 1996. PATIENTS AND METHODS This was a retrospective review of all acute accidents and injuries recorded in the Accident Book since its inception. RESULTS Over 75% of the injuries that were serious enough to result in soldiers having their training terminated were as a direct result of gymnastic events such as vaulting, trampolining and somersaults. These events were also responsible for most of the small number of career-threatening injuries. CONCLUSIONS This raises questions about the inclusion of gymnastic events in course training programmes, especially when considering its relevance to army training in general.


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