Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity
to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles
conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges
including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy
through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to
nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid
and polymeric nanoparticles and their application in tumor targeting.
