Bone Tumours (1): General Characteristics and Benign Lesions

2008 ◽  
pp. 1029-1057
Author(s):  
Dennis J. Stoker ◽  
Asif Saifuddin
Keyword(s):  
Bone Tumours ◽  
Benign Lesions

scholarly journals Central compact osteoma of mandibular condyle

2020 ◽  
Vol 13 (2) ◽  
pp. e233082 ◽  
Author(s):  
Kumar Nilesh ◽  
Aaditee Vande ◽  
Sridhar Reddy
Keyword(s):  
Female Patient ◽  
Paranasal Sinuses ◽  
Mandibular Condyle ◽  
Frontal Bone ◽  
Bone Tumours ◽  
Craniofacial Skeleton ◽  
Benign Lesions ◽  
Comprehensive Review ◽  
Jaw Bones ◽  
Slow Growing

Osteomas are bone tumours arising from the cortical or medullary bones of craniofacial skeleton. Involvement of frontal bone and paranasal sinuses is more frequent than jaw bones. Jaw osteomas are slow growing benign lesions, which are usually asymptomatic or present as painless swelling. Those involving mandibular condyle are relatively rare and result in significant functional and aesthetic disturbances. This paper reports a case of solitary central compact osteoma of mandibular condyle in an adult Indian female patient. A comprehensive review of previously published reports is also presented.

The imaging of cartilaginous bone tumours. I. Benign lesions

2012 ◽  
Vol 41 (10) ◽  
pp. 1195-1212 ◽  
Author(s):  
H. Douis ◽  
A. Saifuddin
Keyword(s):  
Bone Tumours ◽  
Benign Lesions

Pathological fracture in paediatric bone tumours and tumour-like lesions: A predictor of benign lesions?

2021 ◽  
pp. 20201341
Author(s):  
Boussad Chaib ◽  
Karan Malhotra ◽  
Michael Khoo ◽  
Asif Saifuddin
Keyword(s):  
Pathological Fracture ◽  
Plain Radiograph ◽  
Proximal Phalanx ◽  
Bone Tumour ◽  
Final Diagnosis ◽  
Bone Tumours ◽  
Imaging Features ◽  
Benign Lesions ◽  
Pathological Fractures ◽  
Malignant Lesions

Objective: To determine the incidence and causes of pathological fractures in paediatric bone tumours and tumour-like lesions, and to determine if they are predictive of benign lesions. Methods and materials: Retrospective review of children with suspected bone tumours referred to a specialist musculoskeletal oncology service between September 2019 and August 2020. Data recorded included patient age and gender, lesion location, the presence of a pathological fracture on the initial plain radiograph, and the final diagnosis made either by image-guided biopsy/curettage or based on typical imaging features. Results: 231 patients were included with 233 lesions (138 males and 93 females with mean age 10.5 years, range 3 months–18 years). Final diagnosis was based on histology in 85 (36.5%) cases and imaging in 148 (63.5%) cases, 52 (22.3%) lesions classed as non-neoplastic, 139 (59.7%) as benign and 42 (18%) as malignant. Pathological fractures were seen in 41 cases (17.6%) at presentation, involving the humerus in 19 (46.3%), the femur in 14 (34.1%), the tibia in 3 (7.3%), the fibula and radius in two each (4.9%) and the second toe proximal phalanx in 1 (2.4%) (p < 0.001). The commonest underlying lesions included simple bone cyst (n = 17; 41.5%) and non-ossifying fibroma (n = 10; 24.4%). Only 4 cases (9.75%) were malignant, one case each of osteosarcoma, Ewing sarcoma, leukaemia and BCOR undifferentiated round cell sarcoma. Pathological fracture occurred in 27.7% of non-malignant lesions and 9.5% of malignant lesions, this difference being statistically significant (p < 0.001). Conclusion: Pathological fractures were seen in 17.6% of paediatric bone tumours, tumour-like lesions, being significantly associated with humeral location and non-malignant diagnosis. Advances in knowledge: Demonstrates the frequency, location and underlying diagnosis of pathological fractures in paediatric bone tumour and tumour-like lesions.

531: Quantitative Real-Time RT-PCR for AMACR Distinguishes Prostate Cancer with High Specificity From Benign Lesions

2005 ◽  
Vol 173 (4S) ◽  
pp. 145-145 ◽  
Author(s):  
Martin Schostak ◽  
Hans Krause ◽  
Jens Köllermann ◽  
Mark Schrader ◽  
Bernd Straub ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Real Time ◽  
High Specificity ◽  
Rt Pcr ◽  
Benign Lesions

90: Incidence of Benign Lesions for Clinically Localized Renal Masses < 7cm in Radiologic Diameter: Influence of Gender

2006 ◽  
Vol 175 (4S) ◽  
pp. 29-29
Author(s):  
Mark E. Snyder ◽  
Ariadne Bach ◽  
Michael W. Kattan ◽  
Ganesh V. Raj ◽  
Victor E. Reuter ◽  
...  
Keyword(s):  
Benign Lesions ◽  
Renal Masses

Positron emission mammography in the diagnosis of breast cancer

2016 ◽  
Vol 55 (01) ◽  
pp. 15-20 ◽  
Author(s):  
J. Farahati ◽  
A. G. Müller ◽  
E. Gillman ◽  
M. Hentschel ◽  
F. H. H. Müller
Keyword(s):  
Breast Cancer ◽  
High Specificity ◽  
Diagnostic Value ◽  
Glandular Tissue ◽  
Breast Cancer Patients ◽  
Malignant Tumours ◽  
Benign Lesions ◽  
Interventional Study ◽  
Positron Emission Mammography ◽  
Positron Emission

SummaryAim: To evaluate the diagnostic value (sensitivity, specificity) of positron emission mammography (PEM) in a single site non-interventional study using the maximum PEM uptake value (PUVmax). Patients, methods: In a singlesite, non-interventional study, 108 patients (107 women, 1 man) with a total of 151 suspected lesions were scanned with a PEM Flex Solo II (Naviscan) at 90 min p.i. with 3.5 MBq 18F-FDG per kg of body weight. In this ROI(region of interest)-based analysis, maximum PEM uptake value (PUV) was determined in lesions, tumours (PUVmaxtumour), benign lesions (PUVmaxnormal breast) and also in healthy tissues on the contralateral side (PUVmaxcontralateral breast). These values were compared and contrasted. In addition, the ratios of PUVmaxtumour / PUVmaxcontralateral breast and PUVmaxnormal breast / PUVmaxcontralateral breast were compared. The image data were interpreted independently by two experienced nuclear medicine physicians and compared with histology in cases of suspected carcinoma. Results: Based on a criteria of PUV>1.9, 31 out of 151 lesions in the patient cohort were found to be malignant (21%). A mean PUVmaxtumour of 3.78 ± 2.47 was identified in malignant tumours, while a mean PUVmaxnormal breast of 1.17 ± 0.37 was reported in the glandular tissue of the healthy breast, with the difference being statistically significant (p < 0.001). Similarly, the mean ratio between tumour and healthy glandular tissue in breast cancer patients (3.15 ± 1.58) was found to be significantly higher than the ratio for benign lesions (1.17 ± 0.41, p < 0.001). Conclusion: PEM is capable of differentiating breast tumours from benign lesions with 100% sensitivity along with a high specificity of 96%, when a threshold of PUVmax >1.9 is applied.

Significance of 18F-fluorocholine PET/CT positive pulmonary lesions in prostate cancer patients

2015 ◽  
Vol 54 (05) ◽  
pp. 211-216 ◽  
Author(s):  
A. Baskin ◽  
G. Amzalag ◽  
F. Buchegger ◽  
R. Miralbell ◽  
O. Ratib ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Primary Lung Cancer ◽  
Final Diagnosis ◽  
Papillary Adenocarcinoma ◽  
Bronchioloalveolar Carcinoma ◽  
Maximum Diameter ◽  
Benign Lesions ◽  
Pulmonary Carcinoid ◽  
Pulmonary Lesions ◽  
Pet Ct

SummaryAim: To assess the frequency and the significance of incidental pulmonary lesions with 18F-fluorocholine (18F-FCH) PET/CT in prostate cancer (PCa) patients. Patients, methods: 225 consecutive PCa patients referred for 18F-FCH PET/CT (median age 68 years) were retrospectively evaluated for the presence of lesions in the lungs: 173 referred for restaging and 52 for initial staging regarding their high risk of extra prostatic extension. The final diagnosis was based on histopathological or on clinical and radiological follow-up. Results: 13 patients had 18F-FCH positive pulmonary and 8 patients malignant lesions: 5 patients (38%) had a primary lung cancer (2 squamous cell carcinomas, 1 papillary adenocarcinoma, 1 typical pulmonary carcinoid, 1 bronchioloalveolar carcinoma) and 3 patients (23%) PCa metastases. Benign lesions were found in 5 subjects (38%). SUVmax and maximum diameter were neither significantly different in primary and metastatic tumors nor between malignant and benign lesions. Conclusions: Although our results suggest that incidental uptake in the lungs in PCa patients are nonspecific, their detection may have a significant impact on patient management knowing that more than 60% represent malignant diseas.

scholarly journals Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Agnieszka Skorupa ◽  
Mateusz Ciszek ◽  
Ewa Chmielik ◽  
Łukasz Boguszewicz ◽  
Małgorzata Oczko-Wojciechowska ◽  
...  
Keyword(s):  
Nmr Spectra ◽  
Univariate Analysis ◽  
Mas Nmr ◽  
Metabolic Reprogramming ◽  
Benign Lesions ◽  
Chronic Thyroiditis ◽  
Malignant Lesions ◽  
Metabolic Heterogeneity ◽  
Benign Thyroid ◽  
Thyroid Lesions

AbstractThe purpose of this work was to investigate the distinct and common metabolic features of the malignant and benign thyroid lesions in reference to the non-transformed tissue from the contralateral gland (chronic thyroiditis and colloid goiter). 1H HR MAS NMR spectra of 38 malignant lesions, 32 benign lesions and 112 samples from the non-tumoral tissue (32 from chronic thyroiditis and 80 samples from colloid goiter) were subjected both to multivariate and univariate analysis. The increased succinate, glutamine, glutathione, serine/cysteine, ascorbate, lactate, taurine, threonine, glycine, phosphocholine/glycerophosphocholine and decreased lipids were found in both lesion types in comparison to either colloid goiter or chronic thyroiditis. The elevated glutamate and choline, and reduced citrate and glucose were additionally evident in these lesions in reference to goiter, while the increased myo-inositol—in comparison to thyroiditis. The malignant lesions were characterized by the higher alanine and lysine levels than colloid goiter and thyroiditis, while scyllo-inositol was uniquely increased in the benign lesions (not in cancer) in comparison to both non-tumoral tissue types. Moreover, the benign lesions presented with the unique increase of choline in reference to thyroiditis (not observed in the cancerous tissue). The metabolic heterogeneity of the non-tumoral tissue should be considered in the analysis of metabolic reprogramming in the thyroid lesions.

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