Alternative Set Theories

2012 ◽  
pp. 559-632 ◽  
Author(s):  
M. Randall Holmes ◽  
Thomas Forster ◽  
Thierry Libert
Keyword(s):  
Alternative Set

scholarly journals Non-Nucleoside Agonists of the Adenosine Receptors: An Overview

2019 ◽  
Vol 12 (4) ◽  
pp. 150 ◽  
Author(s):  
Dal Ben ◽  
Lambertucci ◽  
Buccioni ◽  
Martí Navia ◽  
Marucci ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Biological Activities ◽  
Great Majority ◽  
Synthetic Route ◽  
Wide Range ◽  
Pharmacological Interest ◽  
Molecular Modeling Studies ◽  
Synthetic Routes ◽  
Alternative Set ◽  
Structural Classes

Potent and selective adenosine receptor (AR) agonists are of pharmacological interest for the treatment of a wide range of diseases and conditions. Among these derivatives, nucleoside-based agonists represent the great majority of molecules developed and reported to date. However, the limited availability of compounds selective for a specific AR subtype (i.e., A2BAR) and a generally long and complex synthetic route for largely substituted nucleosides are the main drawbacks of this category of molecules. Non-nucleoside agonists represent an alternative set of compounds able to stimulate the AR function and based on simplified structures. This review provides an updated overview on the structural classes of non-nucleoside AR agonists and their biological activities, with emphasis on the main derivatives reported in the literature. A focus is also given to the synthetic routes employed to develop these derivatives and on molecular modeling studies simulating their interaction with ARs.

INTERPERSONAL COORDINATION AND EPISTEMIC SUPPORT FOR INTENTIONS WITH WE-CONTENT

2010 ◽  
Vol 26 (3) ◽  
pp. 345-367 ◽  
Author(s):  
Olivier Roy
Keyword(s):  
Game Theory ◽  
Epistemic Logic ◽  
The Other ◽  
Interpersonal Coordination ◽  
Epistemic Game Theory ◽  
Cast Doubt ◽  
Alternative Set

In this paper I study intentions of the form ‘I intend that we . . .’, that is, intentions with a we-content, and their role in interpersonal coordination. I focus on the notion of epistemic support for such intentions. Using tools from epistemic game theory and epistemic logic, I cast doubt on whether such support guarantees the other agents' conditional mediation in the achievement of such intentions, something that appears important if intentions with a we-content are to count as genuine intentions. I then formulate a stronger version of epistemic support, one that does indeed ensure the required mediation, but I then argue that it rests on excessively strong informational conditions. In view of this I provide an alternative set of conditions that are jointly sufficient for coordination in games, and I argue that these conditions constitute a plausible alternative to the proposed notion of epistemic support.

scholarly journals STOPP/START Criteria and Their Role as a Clinical Tool in Routine Practice

2015 ◽  
Vol 2 (6) ◽  
Author(s):  
Denis O'Mahony
Keyword(s):  
Older Persons ◽  
Screening Tool ◽  
Routine Practice ◽  
Potentially Inappropriate Medications ◽  
Clinical Tool ◽  
Treatment Start ◽  
Start Criteria ◽  
Alternative Set ◽  
Explicit Criteria ◽  
Inappropriate Medications

Screening Tool of Older Persons’ Prescriptions (STOPP)/Screening Tool to Alert to Right Treatment (START) criteria was first published in 2008, primarily as an alternative set of explicit criteria for potentially inappropriate medications (PIMs) to Beers criteria.

scholarly journals Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Miriam Kaltenbach ◽  
Colin J Jackson ◽  
Eleanor C Campbell ◽  
Florian Hollfelder ◽  
Nobuhiko Tokuriki
Keyword(s):  
Active Site ◽  
Adaptive Landscape ◽  
Sequence Structure ◽  
Activity Increase ◽  
Enzyme Active Site ◽  
Fundamental Relationship ◽  
And Function ◽  
Alternative Set ◽  
Shed Light ◽  
New Mutations

Understanding the extent to which enzyme evolution is reversible can shed light on the fundamental relationship between protein sequence, structure, and function. Here, we perform an experimental test of evolutionary reversibility using directed evolution from a phosphotriesterase to an arylesterase, and back, and examine the underlying molecular basis. We find that wild-type phosphotriesterase function could be restored (>104-fold activity increase), but via an alternative set of mutations. The enzyme active site converged towards its original state, indicating evolutionary constraints imposed by catalytic requirements. We reveal that extensive epistasis prevents reversions and necessitates fixation of new mutations, leading to a functionally identical sequence. Many amino acid exchanges between the new and original enzyme are not tolerated, implying sequence incompatibility. Therefore, the evolution was phenotypically reversible but genotypically irreversible. Our study illustrates that the enzyme's adaptive landscape is highly rugged, and different functional sequences may constitute separate fitness peaks.

Arguing about the Evidence: a Logical Approach

2011 ◽  
Author(s):  
JOHN FOX
Keyword(s):  
Probabilistic Methods ◽  
Central Idea ◽  
Logical Approach ◽  
Uncertain Evidence ◽  
Alternative Set

This chapter explores ways in which we can be equally rigorous about how to reason about and assess uncertain evidence, using a framework that allows for uncertainty but does not depend on being able to quantify it. It begins by defining what is meant by ‘evidence’ since it has somewhat different interpretations in different fields. It then attempts to develop a unified perspective. The central idea of this unification is that it is based on logic and the patterns of argumentation which are to be seen in deliberations and debates about evidence. The framework does not reject the importance of probabilistic methods for reasoning about evidence but offers a broader perspective which accommodates probabilistic methods when they are practical, and offers an alternative set of methods when they are not.

2. The history of prehistory

2018 ◽  
pp. 7-24
Author(s):  
Chris Gosden
Keyword(s):  
20Th Century ◽  
19Th Century ◽  
History Of ◽  
Internal Sense ◽  
Alternative Set

‘The history of prehistory’ explains how the idea of prehistory arose gradually between the 16th and early 19th centuries in Europe and America, growing large and influential through debates about evolution in the mid-19th century. National and personal identities were problematical, but deeper issues of identity surfaced through 19th-century debates that have never gone away. At the beginning of the 20th century, an alternative set of views emphasized the local specificity and integrity of human cultures. Today, our questions have shifted away from why some people did not ascend to the top rung of the ladder of progress and towards how people created worlds for themselves that made internal sense.

Envisioning a strategic framework to streamline building operation, sustainability and users’ disease control

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Jorge Furtado Falorca
Keyword(s):  
Research Approach ◽  
Content Type ◽  
Strategic Framework ◽  
Software Applications ◽  
Prevention Guideline ◽  
Key Topics ◽  
The Individual ◽  
Building Operation ◽  
Full Swing ◽  
Alternative Set

Purpose This study aims to present a strategic framework aiming to streamline building operation and sustainability issues. To make available a further contribution to respond to Coronavirus Disease 2019 (COVID-19), an operational prevention guideline relying on the level of spread risk has also been developed, primarily intended for users when accessing and circulating within common spaces of buildings in general. Design/methodology/approach The research approach involved the development of a whole theory, essentially based on a qualitative design, by means of tree schematic representations and explanatory frames. It presents part of a model already developed (called SIAPME), although, in general, besides integrating the underlying aspects of the individual experience of daily life, it is based on insights and impressions taken from the literature review. Findings With an identity of its own, this study offers an overview of an alternative set of well-founded and integrated strategies to improve working processes in a number of fields of the building operation function. A structured vision has thus, been provided with interest in certain key topics of the present time, such as energy management, comfort and sustainability. Still, in this context, based on a frame of knowledge gathered to date, a current, innovative and simple guidance has also been designed to help prevent the contagion of COVID-19. Research limitations/implications The draft of procedures is part of an ambitious goal to serve as a well-founded strategic basis for the eventual development of an advanced software solution. As it is mainly limited to qualitative analysis, from which themes and generalisations have been arranged, this research may need more empirical evidence and additional work will be necessary to overcome any gaps that may be found. Practical implications An overall assessment of this study seems to corroborate the idea that a significant impact on the developments in building operation can occur if stakeholders seek a more integrated way of management, based on cross-referencing of current issues. At a time when great uncertainties remain and knowledge advances are in full swing, the designed framework aims to be an added input towards already existing research. Furthermore, it can be seen as a valuable contribution to improving related software applications. Originality/value The originality lies in trying to better understand how and in which aspects the general day-to-day management of building operation can be handled more effectively, sustainable and framed, following a reasoned scientific line, in addition of trying to figure out greater capacity to deal with users’ contagions, especially in the existing context of the pandemic.

scholarly journals External Economies and International Trade Redux: Comment*

2013 ◽  
Vol 128 (4) ◽  
pp. 1895-1905 ◽  
Author(s):  
Gary Lyn ◽  
Andrés Rodríguez-Clare
Keyword(s):  
International Trade ◽  
Multiple Equilibria ◽  
Mixed Strategy ◽  
Equilibrium Analysis ◽  
Perfect Competition ◽  
Transport Costs ◽  
Trade Patterns ◽  
Strategy Equilibrium ◽  
Pure Strategies ◽  
Alternative Set

Abstract Recently, Gene Grossman and Esteban Rossi-Hansberg (GRH; “External Economies and International Trade: Redux,” Quarterly Journal of Economics 125 [2010], 829–858) proposed a novel way to think about the implications of international trade in the presence of national external economies at the industry level. Instead of perfect competition and two industries, GRH assume Bertrand competition and a continuum of industries. GRH conclude that the equilibrium is unique if transport costs are low, that there is no trade for high transport costs, and that there is no equilibrium in pure strategies when transport costs are intermediate. In this note we reexamine the equilibrium analysis under different transport costs for a single industry (partial equilibrium) version of GRH’s model. We confirm many of GRH’s results, but also find that there are circumstances under which there are multiple equilibria, including equilibria in which trade patterns run counter to “natural” comparative advantage, and also find that there is a profitable deviation to the mixed-strategy equilibrium postulated by GRH for intermediate trading costs. We propose an alternative set of strategies for this case and establish that they constitute an equilibrium.

scholarly journals Topology in the Alternative Set Theory and Rough Sets via Fuzzy Type Theory

Mathematics ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 432 ◽  
Author(s):  
Vilém Novák
Keyword(s):  
Fuzzy Logic ◽  
Set Theory ◽  
Rough Set ◽  
Fuzzy Set ◽  
Fuzzy Set Theory ◽  
Rough Sets ◽  
Type Theory ◽  
Rough Set Theory ◽  
Basic Concepts ◽  
Alternative Set

In this paper, we will visit Rough Set Theory and the Alternative Set Theory (AST) and elaborate a few selected concepts of them using the means of higher-order fuzzy logic (this is usually called Fuzzy Type Theory). We will show that the basic notions of rough set theory have already been included in AST. Using fuzzy type theory, we generalize basic concepts of rough set theory and the topological concepts of AST to become the concepts of the fuzzy set theory. We will give mostly syntactic proofs of the main properties and relations among all the considered concepts, thus showing that they are universally valid.

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