RELEVANCE OF PRECLINICAL PHARMACOLOGY AND TOXICOLOGY TO PHASE I TRIAL EXTRAPOLATION TECHNIQUES: RELEVANCE OF ANIMAL TOXICOLOGY

Anticancer Drug Development ◽

10.1016/b978-012072651-6/50018-8 ◽

2002 ◽

pp. 301-328 ◽

Author(s):

Joseph E. Tomaszewski ◽

Adaline C. Smith ◽

Joseph M. Covey ◽

Susan J. Donohue ◽

Julie K. Rhie ◽

...

Keyword(s):

Phase I ◽

Phase I Trial ◽

Preclinical Pharmacology ◽

Pharmacology And Toxicology

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604: A Phase I Trial of Vaccination of Personalized Peptides for HLA-A2/A24 Positive Patients with Hormone-Refractory Prostate Cancer

The Journal of Urology ◽

10.1016/s0022-5347(18)30844-9 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 202-202

Author(s):

Hirotsugu Uemura ◽

Motoyoshi Tanaka ◽

Shigeya Uejima ◽

Takafumi Minami ◽

Kiyohide Fujimoto ◽

...

Keyword(s):

Prostate Cancer ◽

Phase I ◽

Phase I Trial ◽

Hormone Refractory Prostate Cancer ◽

Hormone Refractory

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Phase I Trial and Pharmacokinetics Study of the Farnesyltransferase Inhibitor Tipifarnib in Children With Refractory Solid Tumors or Neurofibromatosis Type I and Plexiform Neurofibromas

Yearbook of Oncology ◽

10.1016/s1040-1741(08)70478-0 ◽

2007 ◽

Vol 2007 ◽

pp. 292-293

Author(s):

R.J. Arceci

Keyword(s):

Phase I ◽

Solid Tumors ◽

Phase I Trial ◽

Neurofibromatosis Type ◽

Type I ◽

Neurofibromatosis Type I ◽

Farnesyltransferase Inhibitor ◽

Plexiform Neurofibromas ◽

Pharmacokinetics Study

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The PACOVAR-trial: A multicenter phase I trial of pazopanib (GW786034) and metronomic cyclophosphamide in patients with recurrent platinum-resistant ovarian cancer

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0036-1592664 ◽

2016 ◽

Vol 76 (10) ◽

Author(s):

C Mayer ◽

M Schmidt ◽

EM Grischke ◽

G Gebauer ◽

HC Fricke ◽

...

Keyword(s):

Ovarian Cancer ◽

Phase I ◽

Phase I Trial ◽

Multicenter Phase ◽

Platinum Resistant ◽

Metronomic Cyclophosphamide

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A Randomized, Single-Blind, Phase I Trial (INVICTAN®-1) Assessing the Pharmacokinetic Bioequivalence and Safety of BI 695502, a Bevacizumab Biosimilar Candidate, in Healthy Subjects

10.26226/morressier.57d6b2b8d462b8028d88ea33 ◽

2016 ◽

Author(s):

Mario Altendorfer

Keyword(s):

Phase I ◽

Healthy Subjects ◽

Phase I Trial ◽

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Faculty Opinions recommendation of Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1164720.626529 ◽

2009 ◽

Author(s):

Paul Nghiem ◽

Kelly Paulson

Keyword(s):

Phase I ◽

Metastatic Melanoma ◽

Phase I Trial ◽

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Faculty Opinions recommendation of A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5045975.4981082 ◽

2010 ◽

Author(s):

David Brooks ◽

Nicola Pavese

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Deep Brain Stimulation ◽

Phase I ◽

Brain Stimulation ◽

Phase I Trial ◽

Memory Circuits ◽

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Faculty Opinions recommendation of Phase I trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718040504.793483426 ◽

2013 ◽

Author(s):

Roberto Angioli

Keyword(s):

Ovarian Cancer ◽

Phase I ◽

Phase I Trial ◽

Recurrent Ovarian Cancer ◽

Platinum Sensitive ◽

Docetaxel Chemotherapy

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Faculty Opinions recommendation of Safety and tolerability of intrathecal delivery of autologous bone marrow nucleated cells in children with cerebral palsy: an open-label phase I trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718318264.793494245 ◽

2014 ◽

Author(s):

Joanne Kurtzberg ◽

Jessica Sun

Keyword(s):

Bone Marrow ◽

Cerebral Palsy ◽

Phase I ◽

Phase I Trial ◽

Autologous Bone Marrow ◽

Children With Cerebral Palsy ◽

Open Label Phase ◽

Autologous Bone

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Faculty Opinions recommendation of Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718514016.793503134 ◽

2015 ◽

Author(s):

Qing Zhong

Keyword(s):

Phase I ◽

Solid Tumors ◽

Phase I Trial ◽

Advanced Solid Tumors

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Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non–BRCA1/2-Mutant Cancers

Cancer Discovery ◽

10.1158/2159-8290.cd-20-0163 ◽

2020 ◽

Vol 10 (10) ◽

pp. 1528-1543 ◽

Author(s):

Timothy A. Yap ◽

Rebecca Kristeleit ◽

Vasiliki Michalarea ◽

Stephen J. Pettitt ◽

Joline S.J. Lim ◽

...

Keyword(s):

Phase I ◽

Phase I Trial ◽

Parp Inhibitor ◽

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