Insular dentin formation pattern in human odontogenesis in relation to the scalloped dentino-enamel junction

In cases of pulp injury, capping materials are used to enhance tertiary dentin formation; Ca(OH)2 and MTA are the current gold standards. The aim of this study was to evaluate the capacity of a new calcium-silicate-based restorative cement to induce pulp healing in a rat pulp injury model. For that purpose, cavities with mechanical pulp exposure were prepared on maxillary first molars of 27 six-week-old male rats, and damaged pulps were capped with either the new calcium-silicate-based restorative cement (Biodentine), MTA, or Ca(OH)2. Cavities were sealed with glass-ionomer cement, and the repair process was assessed at several time-points. At day 7, our results showed that both the evaluated cement and MTA induced cell proliferation and formation of mineralization foci, which were strongly positive for osteopontin. At longer time-points, we observed the formation of a homogeneous dentin bridge at the injury site, secreted by cells displaying an odontoblastic phenotype. In contrast, the reparative tissue induced by Ca(OH)2 showed porous organization, suggesting a reparative process different from those induced by calcium silicate cements. Analysis of these data suggests that the evaluated cement can be used for direct pulp-capping.

Download Full-text

Spine formation pattern of new neurons is modulated by induction of long-term potentiation (LTP) in adult dentate gyrus

Neuroscience Research ◽

10.1016/j.neures.2009.09.321 ◽

2009 ◽

Vol 65 ◽

pp. S83

Author(s):

Noriaki Ohkawa ◽

Yoshito Saitoh ◽

Eri Tokunaga ◽

Toshio Kitamura ◽

Kaoru Inokuchi

Keyword(s):

Dentate Gyrus ◽

Long Term Potentiation ◽

Spine Formation ◽

Term Potentiation ◽

Formation Pattern

Download Full-text

Involvement of the Klotho Protein in Dentin Formation and Mineralization

The Anatomical Record ◽

10.1002/ar.20630 ◽

2008 ◽

Vol 291 (2) ◽

pp. 183-190 ◽

Cited By ~ 9

Author(s):

Hironobu Suzuki ◽

Norio Amizuka ◽

Kimimitsu Oda ◽

Masaki Noda ◽

Hayato Ohshima ◽

...

Keyword(s):

Klotho Protein ◽

Dentin Formation

Download Full-text

PHEX neutralizing agent inhibits dentin formation in mouse tooth germ

Tissue and Cell ◽

10.1016/j.tice.2010.12.008 ◽

2011 ◽

Vol 43 (2) ◽

pp. 125-130 ◽

Cited By ~ 2

Author(s):

Hongbing Lv ◽

Sheng Fu ◽

Gancha Wu ◽

Fuhua Yan

Keyword(s):

Tooth Germ ◽

Neutralizing Agent ◽

Dentin Formation

Download Full-text

Local Irradiation of Mouse Tooth Germ Gives Insight into the Direct Effects of Irradiation on Root Development

Radiation Research ◽

10.1667/rade-20-00081.1 ◽

2021 ◽

Author(s):

Yoshiaki Ide ◽

Taka Nakahara ◽

Tetsuya Fukada ◽

Masanori Nasu

Keyword(s):

Root Development ◽

Root Formation ◽

Tooth Germ ◽

Lead Glass ◽

Local Irradiation ◽

Root Sheath ◽

Calcified Tissue ◽

Radiation Induced ◽

Dentin Formation ◽

Root Apices

To elucidate the mechanism underlying the failure of root formation after irradiation, we established a method of local irradiation of the molar tooth germ and demonstrated that radiation directly affected dental root development. In the current study, to locally irradiate the lower first molars of 5-day-old C57BL/6J mice, we used lead glass containing a hole as a collimator. We confirmed that our local irradiation method targeted only the tooth germ. The irradiated root was immature in terms of apical growth, and dentin formation was irregular along the outside of the root apices. Moreover, calcified tissue apically surrounded Hertwig's epithelial root sheath, which disappeared abnormally early. This method using a local irradiation experimental model will facilitate research into radiation-induced disorders of dental root formation.

Download Full-text

Morphologie und Semantik der n-Erweiterung bei Muttern und Vatern im Deutschen

Zeitschrift für Wortbildung / Journal of Word Formation ◽

10.3726/zwjw.2021.01.02 ◽

2021 ◽

Vol 5 (1) ◽

pp. 37-79

Author(s):

Alexander Werth

Keyword(s):

Word Formation ◽

Limited Extent ◽

Prepositional Phrases ◽

Low German ◽

German Dialects ◽

Semantic Concepts ◽

Formation Pattern ◽

Word Forms ◽

Comparative Constructions

Abstract: This paper deals with German kinship terms ending with the form n (Muttern, Vatern). Firstly, data from newspapers are presented that show that especially Muttern denotes very special meanings that can only be derived to a limited extent from the lexical base: a) Muttern referring to a home where mother cares for you, b) Muttern standing for overprotection, and c) Muttern representing a special food style (often embedded in prepositional phrases and/or comparative constructions like wie bei or wie von Muttern). Secondly, it is argued that the addition of n to kinship terms is not a word-formation pattern, but that these word forms are instead lexicalized and idiomatized in contemporary German. Hence, a diachronic scenario is applied to account for the data. It is argued in the present paper that the n-forms have been borrowed from Low German dialects, especially from constructional idioms of the type ‘X-wie bei Muttern’ and that forms were enriched by semantic concepts associated with the dialect.

Download Full-text

A Novel Framework for Multi-Agent Systems Using a Decentralized Strategy

Robotica ◽

10.1017/s0263574718001261 ◽

2018 ◽

Vol 37 (4) ◽

pp. 691-707 ◽

Cited By ~ 4

Author(s):

Mehmet Serdar Güzel ◽

Vahid Babaei Ajabshir ◽

Panus Nattharith ◽

Emir Cem Gezer ◽

Serhat Can

Keyword(s):

Detection Algorithm ◽

Multi Agent Systems ◽

Efficient Manner ◽

Agent Systems ◽

Cluttered Environment ◽

Formation Pattern ◽

Multi Agent ◽

Overall Performance ◽

Goal Detection ◽

New Framework

SummaryThis work addresses a new framework that proposes a decentralized strategy for collective and collaborative behaviours of multi-agent systems. This framework includes a new clustering behaviour that causes agents in the swarm to agree on attending a group and allocating a leader for each group, in a decentralized and local manner. The leader of each group employs a vision-based goal detection algorithm to find and acquire the goal in a cluttered environment. As soon as the leader starts moving, each member is enabled to move in the same direction by staying coordinated with the leader and maintaining the desired formation pattern. In addition, an exploration algorithm is designed and integrated into the framework so as to allow each group to be able to explore goals in a collaborative and efficient manner. A series of comprehensive experiments are conducted in order to verify the overall performance of the proposed framework.

Download Full-text

Control of wave formation pattern in self-oscillating gel by addition of hydroquinone in the Belosov-Zhabotinsky reaction solution

Polymer Bulletin ◽

10.1007/s00289-005-0373-6 ◽

2005 ◽

Vol 54 (3) ◽

pp. 215-223

Author(s):

Do Sung Huh ◽

Jong Kon Kang ◽

Young Joon Kim ◽

Ryo Yoshida

Keyword(s):

Wave Formation ◽

Reaction Solution ◽

Formation Pattern

Download Full-text

Lithium Chloride Exerts Differential Effects on Dentinogenesis and Osteogenesis in Primary Pulp Cultures

Frontiers in Dental Medicine ◽

10.3389/fdmed.2021.649500 ◽

2021 ◽

Vol 2 ◽

Author(s):

Anushree Vijaykumar ◽

Mina Mina

Keyword(s):

Dental Pulp ◽

Osteoblast Differentiation ◽

Prolonged Treatment ◽

Odontoblast Differentiation ◽

Positive Effects ◽

Reparative Dentin ◽

Dentin Formation ◽

Reparative Dentin Formation

Wnt/β-catenin signaling is known to play essential roles in odontoblast differentiation and reparative dentin formation. Various Wnt activators including LiCl have been increasingly studied for their effectiveness to induce repair of the dentin-pulp complex. LiCl is a simple salt thought to activate Wnt/β-catenin signaling by inhibiting GSK3β. Previous in vitro and in vivo studies showed that LiCl increased odontoblast differentiation and enhanced reparative dentin formation. However, the underlying molecular and cellular mechanisms by which LiCl regulates odontoblast and osteoblast differentiation during reparative dentinogenesis are not well-understood. Our in vitro studies show that exposure of early dental pulp progenitors to LiCl increased the survival and the pool of αSMA+ progenitors, leading to enhanced odontoblast and osteoblast differentiation. The positive effects of LiCl in the differentiation of osteoblasts and odontoblasts from αSMA+ progenitors are mediated by Wnt/β-catenin signaling. Our results also showed that continuous and late exposure of dental pulp cells to LiCl increased the expression of odontoblast markers through Wnt/β-catenin signaling, and the number of odontoblasts expressing DMP1-Cherry and DSPP-Cerulean transgenes. However, unlike the early treatment, both continuous and late treatments decreased the expression of Bsp and the expression of BSP-GFPtpz transgene. These observations suggest that prolonged treatment with LiCl in more mature cells of the dental pulp has an inhibitory effect on osteoblast differentiation. The inhibitory effects of LiCl on osteogenesis and Bsp were not mediated through Wnt/β-catenin signaling. These observations suggest that the effects of LiCl, and GSK3β antagonists on reparative dentinogenesis involve multiple pathways and are not specific to Wnt/β-catenin signaling.

Download Full-text