Classification of membrane protein using Tetra Peptide Pattern

2020 ◽  
Vol 606 ◽  
pp. 113845
Author(s):  
A. Sherly Alphonse ◽  
N. Ani Brown Mary ◽  
M.S. Starvin
Keyword(s):  
Membrane Protein ◽  
Peptide Pattern

scholarly journals Piscine reovirus encodes a cytotoxic, non-fusogenic, integral membrane protein and previously unrecognized virion outer-capsid proteins

2013 ◽  
Vol 94 (5) ◽  
pp. 1039-1050 ◽  
Author(s):  
Tim Key ◽  
Jolene Read ◽  
Max L. Nibert ◽  
Roy Duncan
Keyword(s):  
Membrane Protein ◽  
Syncytium Formation ◽  
Integral Membrane Protein ◽  
Capsid Proteins ◽  
The Family ◽  
Farmed Atlantic Salmon ◽  
Outer Capsid ◽  
Sequence Similarities ◽  
Current Report

Piscine reovirus (PRV) is a tentative new member of the family Reoviridae and has been linked to heart and skeletal muscle inflammation in farmed Atlantic salmon (Salmo salar L.). Recent sequence-based evidence suggests that PRV is about equally related to members of the genera Orthoreovirus and Aquareovirus. Sequence similarities have also suggested that PRV might encode a fusion-associated small transmembrane (FAST) protein, which in turn suggests that PRV might be the prototype of a new genus with syncytium-inducing potential. In previous support of this designation has been the absence of identifiable PRV-encoded homologues of either the virion outer-clamp protein of ortho- and aquareoviruses or the virion outer-fibre protein of most orthoreoviruses. In the current report, we have provided experimental evidence that the putative p13 FAST protein of PRV lacks the defining feature of the FAST protein family – the ability to induce syncytium formation. Instead, p13 is the first example of a cytosolic, integral membrane protein encoded by ortho- or aquareoviruses, and induces cytotoxicity in the absence of cell–cell fusion. Sequence analysis also identified signature motifs of the outer-clamp and outer-fibre proteins of other reoviruses in two of the predicted PRV gene products. Based on these findings, we conclude that PRV does not encode a FAST protein and is therefore unlikely to be a new fusogenic reovirus. The presence of a novel integral membrane protein and two previously unrecognized, essential outer-capsid proteins has important implications for the biology, evolution and taxonomic classification of this virus.

scholarly journals A New Functional Classification of Glucuronoyl Esterases by Peptide Pattern Recognition

2017 ◽  
Vol 08 ◽  
Author(s):  
Jane W. Agger ◽  
Peter K. Busk ◽  
Bo Pilgaard ◽  
Anne S. Meyer ◽  
Lene Lange
Keyword(s):  
Pattern Recognition ◽  
Functional Classification ◽  
Peptide Pattern ◽  
Peptide Pattern Recognition

scholarly journals Multilabel Classification of Membrane Protein in Human by Decision Tree (DT) Approach

2018 ◽  
Vol 11 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Nijil Raj N ◽  
T. Mahalekshmi
Keyword(s):  
Membrane Protein ◽  
Decision Tree ◽  
Protein Function ◽  
Cellular Processes ◽  
Semantic Scene ◽  
Class Labels ◽  
Essential Set ◽  
Type Classification ◽  
Better Than

Multi-label classification methods are important in various fields,such as protein type,protein function, semantic scene classification and music categorization . In multi-label classification, each sample can be associated with a set of class labels. In protein type classification, one of the major types of protein is membrane protein. The Membrane proteins are performing different cellular processes and important functions, which are based on the protein types. Each membrane protein have different rolls at the same time. In this study we proposes membrane protein type classification using Decision Tree (DT) classification algorithm. The DT classifies a membrane protein into six types . An essential set of features are extracted from the membrane protein dataset S1 which are used for the proposed method,and it was revealed an accuracy of 69.81%, whereas existing methods network based and shortest path revealed an accuracy of 66.78%,54.97%.The accuracy got in the existing methods are not for the full set of protein in dataset S1, but it is achieved after removal of few unannotated protein. Both accuracy wise and complexity wise, the proposed method seems to be better than the existing method

Proteomic Screening Applied to the Diagnosis of Chronic Graft-Versus-Host-Disease.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 1164-1164
Author(s):  
Eva M. Mischak-Weissinger ◽  
Michael Stadler ◽  
Ernst Holler ◽  
Michael Schleuning ◽  
Hildegard Greinix ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Acute Gvhd ◽  
Chronic Gvhd ◽  
Correct Classification ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Peptide Pattern ◽  
Conditioning Regimens

Abstract Abstract 1164 Poster Board I-186 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for many hematologic malignancies or hematopoietic dysfunction syndromes, but the application is still limited due to major complications, such as severe graft versus host disease (GvHD) and infectious complications. Diagnosis chronic GvHD is based on clinical features and biopsies, a non invasive, unbiased laboratory test does not exist. We used the urine collected from 20 patients (10 with limited cGvHD, 10 with extensive cGvHD) to establish a proteomic pattern that allowed the diagnosis of cGvHD development and tested the resulting set of polypeptide markers (27 differentially excreted peptides) on more than 200 patients prospectively and blinded for the correct classification of cGvHD samples. The majority of the patients included were transplanted for hematological malignancies (n=209), 6 for hematopoietic failure syndromes. Conditioning regimens included dose reduced conditioning regimens (FLAMSA and ClaraC for the majority of the patients of MHH), as well as standard conditioning regimens (TBI+Cy or Busulfan+Cy) for about 35% of the patients, with GvHD-prophylaxis including cyclosporine A and mycophenolate (MMF) or metothrexate (MTX) as appropriate. Eighty percent of the patients received ATG (antithymocyte globulin) prior to HSCT. A peptide pattern of 27 peptides, differentiating chronic from acute GvHD was developed. Controls were patients at least 100 days post HSCT, with no GvHD in the history, no infections and without relapse at the time of sampling. Prospective and blinded evaluation of the patients revealed the correct classification of patients developing cGvHD with a sensitivity of 85% and specificity of 95%.Further evaluation of the cGvHD patterns specific for particular organ manifestations of cGvHD are currently ongoing. Interestingly, the cGvHD pattern seems to be predictive for GvHD developing post DLI, while the aGvHD-specific proteomic pattern only predicts GvHD of the intestine, which may be more similar to “late acute GvHD”. Disclosures Krons: mosaiques-diagnostics GmbH: Employment. Metzger:mosaiques-diagnostics GmbH: Employment.

Note on the spectral classification of carbon stars in the photographic infrared region

1966 ◽  
Vol 24 ◽  
pp. 21-23
Author(s):  
Y. Fujita
Keyword(s):  
Infrared Region ◽  
Spectral Classification ◽  
Carbon Stars

We have investigated the spectrograms (dispersion: 8Å/mm) in the photographic infrared region fromλ7500 toλ9000 of some carbon stars obtained by the coudé spectrograph of the 74-inch reflector attached to the Okayama Astrophysical Observatory. The names of the stars investigated are listed in Table 1.

Diagnostic Value of Electron Microscopy in Soft Tissue Tumors

1970 ◽  
Vol 28 ◽  
pp. 220-221
Author(s):  
Gerald Fine ◽  
Azorides R. Morales
Keyword(s):  
Cardiac Myxoma ◽  
Osteogenic Sarcoma ◽  
Diagnostic Value ◽  
Soft Tissue Tumors ◽  
Amelanotic Melanoma ◽  
Growth Patterns ◽  
Light Microscopic Level ◽  
Mesenchymal Tumors ◽  
Good Agreement

For years the separation of carcinoma and sarcoma and the subclassification of sarcomas has been based on the appearance of the tumor cells and their microscopic growth pattern and information derived from certain histochemical and special stains. Although this method of study has produced good agreement among pathologists in the separation of carcinoma from sarcoma, it has given less uniform results in the subclassification of sarcomas. There remain examples of neoplasms of different histogenesis, the classification of which is questionable because of similar cytologic and growth patterns at the light microscopic level; i.e. amelanotic melanoma versus carcinoma and occasionally sarcoma, sarcomas with an epithelial pattern of growth simulating carcinoma, histologically similar mesenchymal tumors of different histogenesis (histiocytoma versus rhabdomyosarcoma, lytic osteogenic sarcoma versus rhabdomyosarcoma), and myxomatous mesenchymal tumors of diverse histogenesis (myxoid rhabdo and liposarcomas, cardiac myxoma, myxoid neurofibroma, etc.)

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