Characterization of factors affecting the release of low-solubility drug from prolonged release tablets

2004 ◽  
Vol 502 (1) ◽  
pp. 107-113 ◽  
Author(s):  
M Kincl ◽  
F Vrečer ◽  
M Veber
Keyword(s):  
Prolonged Release ◽  
Factors Affecting ◽  
Low Solubility

scholarly journals Conditions to Prolonged Release of Microencapsulated Carvacrol on Alginate Films as Affected by Emulsifier Type and PH

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Silvia Matiacevich ◽  
Natalia Riquelme ◽  
María Lidia Herrera
Keyword(s):  
Storage Time ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Edible Film ◽  
Initial Time ◽  
Tween 20 ◽  
Prolonged Release ◽  
E Coli ◽  
Fresh Foods

Alginate from algal biomass is used as edible film and the incorporation of antimicrobial agents improves its performance to increase the shelf-life of fresh foods. However, environmental conditions and intrinsic properties of films influence their release. The aim of this study was to investigate the effect of the concentration and type of encapsulating agent and pH of emulsions on the physical and antimicrobial properties of alginate-carvacrol films. Films containing alginate, carvacrol as antimicrobial agent, and Tween 20 or trehalose (0.25 and 0.75% w/w) as encapsulating agents were obtained from suspensions at pH 4 and pH 8. Physical characterization of emulsions and films and antimicrobial properties (E. coliandB. cinerea) was evaluated. Results showed that droplets size depended on trehalose concentration, but emulsion stability depended on pH and type of encapsulating agent, being more stable samples with trehalose at pH 4. Although films with Tween 20 presented the highest opacity, they showed the best antimicrobial properties at initial time; however, during storage time, they lost their activity before samples with trehalose and relative humidity (RH) was the principal factor to influence their release. Therefore, sample formulated with 0.25% trehalose at pH 4 and stored at 75% RH had the best potential as edible film for fresh fruits.

scholarly journals Obtaining and Characterization of a Polyurethane Carrier Used for Eugenol as a Possible Remedy in Oral Therapies

2018 ◽  
Vol 55 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Zoran Popa ◽  
Laura Cristina Rusu ◽  
Razvan Susan ◽  
Iulia Pinzaru ◽  
Elena Ardelean ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Thermal Stability ◽  
Thermal Decomposition ◽  
Drug Delivery System ◽  
Transmembrane Transport ◽  
Vein Wall ◽  
Good Thermal Stability ◽  
Toxicity Effect ◽  
Low Solubility

The cloves are antiseptic, antiparasitic, antibacterial, antifungal, antiviral, anesthetic, analgesic, anti-inflammatory, tonic, carminative, anti-ulcer, antithrombotic, antioxidant and anti-cancerous. They contain eugenol, tannins and flavonoids that also help to strengthen the vein wall. This paper presents the obtaining and the characterization of a polyurethane drug delivery system which can be used for the transmembrane transport of eugenol in oral therapies. The products were analyzed by pH and solubility measurements, thermal decomposition and zetasizer tests and they were applied on mice skin to evaluate their harmfulness. The results suggest that were obtained neutral pH structures with low solubility and a good thermal stability, with sizes between 241 and 289 nm and no toxicity effect was found in the case of studied samples.

scholarly journals Crystallographic and structural characterization of heterometallic platinum compounds. Part II. Heterobinuclear Pt compounds with Pt⋯M (M = transition or lantanide metal) > 3.0 Å

2012 ◽  
Vol 10 (6) ◽  
pp. 1709-1759 ◽  
Author(s):  
Milan Melnik ◽  
Ondrej Sprusansky ◽  
Clive Holloway
Keyword(s):  
Transition Metal ◽  
Chlorine Atom ◽  
Structural Characterization ◽  
Platinum Compounds ◽  
Factors Affecting ◽  
Bond Lengths ◽  
Trigonal Bipyramidal ◽  
Square Planar ◽  
Independent Molecules

AbstractThis review covers almost two hundred and twenty heterobinuclear platinum compounds in which Pt⋯M separation is over 3.0 Å. The M is a transition metal (Cu, Ag, Au, Ti, V, Cr, Mo, W, Mn, Re, Fe, Ru, Os, Co, Rh, Ir, Ni and Pd). There is an example of a lanthanide, Yb and a actinide, U. The Pt atom has oxidation numbers 0, +2 and +4. The Pt coordination geometries include trigonal planar Pt(0); square planar Pt(II); trigonal bipyramidal, and pseudo octahedral Pt(IV), with the most frequent being square planar. The most common ligands for Pt are P and C donor atoms, as well as a chlorine atom. The Pt — Ag distance of 3.002(1) Å is the shortest found in this series. There are examples which contain two crystallographically independent molecules, which differ mostly by degree of distortion and even one unique example, which contains eight such molecules. These are examples of distortion isomerism. Factors affecting bond lengths and angles are discussed and some ambiguities in coordination polyhedral are outlined.

Study on genetic parameters of some economic traits in Iranian indigenous silkworm races

2005 ◽  
Vol 2005 ◽  
pp. 136-136
Author(s):  
S. Z. Mirhosseini ◽  
M. Mavajpoor ◽  
M. Ghanipoor ◽  
A. Seidavi
Keyword(s):  
Natural Fiber ◽  
Phenotypic Characterization ◽  
Economic Traits ◽  
Shell Weight ◽  
Essential Information ◽  
Factors Affecting ◽  
Breeding Programmes ◽  
Low Performance ◽  
Successive Generations

Silkworms are well-known industrial insects, which produce natural fiber silk. Because of economic importance for silk yarn, an effort to breed new silkworm variety has been made for thousand years. High cocoon yielding due to high resistance, high silk reeling ability and productivity, better silk quality in neatness and lousiness is essential for new silkworm variety to increase silk productivity. Today, several hundred varieties have been bred accordingly various interests and purposes (Kang et al., 2001, 2002). Pupation rate, single cocoon weight, cocoon shell weight and cocoon shell percentage are the main factors affecting the high yielding of cocoon (Kang et al., 2001, 2002). Native silkworm varieties have the low performance and could not be commercially employed. Indigenous strains are valuable genetic resources. They have been affected by natural selection in the successive generations and adapted to indigenous diseases and environmental conditions. Genetic and phenotypic characterization of locally available native silkworm populations provides essential information to make rational decisions for the improvement and development of effective breeding programmes. Hence, the present study was undertaken to identify genetic potential of indigenous silkworm for designing suitable breeding programmes.

scholarly journals Genetic diversity in Italian Lactobacillus sanfranciscensis strains assessed by multilocus sequence typing and pulsed-field gel electrophoresis analyses

Microbiology ◽  
2010 ◽  
Vol 156 (7) ◽  
pp. 2035-2045 ◽  
Author(s):  
Claudia Picozzi ◽  
Gaia Bonacina ◽  
Ileana Vigentini ◽  
Roberto Foschino
Keyword(s):  
Multilocus Sequence Typing ◽  
Geographical Area ◽  
Housekeeping Genes ◽  
Processing Conditions ◽  
Clonal Population ◽  
Factors Affecting ◽  
Lactobacillus Sanfranciscensis ◽  
Mlst Scheme ◽  
Sequence Types

Lactobacillus sanfranciscensis is a lactic acid bacterium that characterizes the sourdough environment. The genetic differences of 24 strains isolated in different years from sourdoughs, mostly collected in Italy, were examined and compared by PFGE and multilocus sequence typing (MLST). The MLST scheme, based on the analysis of six housekeeping genes (gdh, gyrA, mapA, nox, pgmA and pta) was developed for this study. PFGE with the restriction enzyme ApaI proved to have higher discriminatory power, since it revealed 22 different pulsotypes, while 19 sequence types were recognized through MLST analysis. Notably, restriction profiles generated from three isolates collected from the same firm but in three consecutive years clustered in a single pulsotype and showed the same sequence type, emphasizing the fact that the main factors affecting the dominance of a strain are correlated with processing conditions and the manufacturing environment rather than the geographical area. All results indicated a limited recombination among genes and the presence of a clonal population in L. sanfranciscensis. The MLST scheme proposed in this work can be considered a useful tool for characterization of isolates and for in-depth examination of the strain diversity and evolution of this species.

scholarly journals Characterization of Factors Affecting Properties of Rice Cake and Its Structure.

1997 ◽  
Vol 3 (1) ◽  
pp. 6-9 ◽  
Author(s):  
Toshiyuki WATANABE ◽  
Yutaka HASHIMOTO ◽  
Toshio JOH ◽  
Toshiro HAYAKAWA
Keyword(s):  
Rice Cake ◽  
Factors Affecting
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