Stability-indicating high performance thin layer chromatography determination of Paroxetine hydrochloride in bulk drug and pharmaceutical formulations

2007 ◽  
Vol 598 (2) ◽  
pp. 312-317 ◽  
Author(s):  
A. Venkatachalam ◽  
Vidya S. Chatterjee
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Pharmaceutical Formulations ◽  
Stability Indicating ◽  
Bulk Drug ◽  
Paroxetine Hydrochloride ◽  
Layer Chromatography

Determination of poloxamer 188 and poloxamer 407 using high-performance thin-layer chromatography in pharmaceutical formulations

2008 ◽  
Vol 46 (4) ◽  
pp. 799-803 ◽  
Author(s):  
Z. Urbán-Morlán ◽  
R. Castro-Ríos ◽  
A. Chávez-Montes ◽  
L.M. Melgoza-Contreras ◽  
E. Piñón-Segundo ◽  
...  
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Pharmaceutical Formulations ◽  
Poloxamer 407 ◽  
Poloxamer 188 ◽  
Layer Chromatography

scholarly journals Comparison of high-performance thin layer chromatography/UV-densitometry and UV-derivative spectrophotometry for the determination of trimetazidine in pharmaceutical formulations

2019 ◽  
Vol 69 (3) ◽  
pp. 413-422
Author(s):  
Marcin Gackowski ◽  
Marcin Koba ◽  
Katarzyna Mądra-Gackowska ◽  
Stefan Kruszewski
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Pharmaceutical Formulations ◽  
Linear Calibration ◽  
Accuracy And Precision ◽  
Significant Difference ◽  
Trimetazidine Dihydrochloride ◽  
Layer Chromatography

Abstract New methods for assaying trimetazidine dihydrochloride on the basis of thin layer chromatography and spectrophotometry are proposed and compared in the paper. In HPTLC/UV-densitometry, separation is achieved by using a mobile phase composed of ammonia-methanol (30:70, V/V) on silica gel HPTLC plates F254. Quantification using a non-linear calibration curve is accomplished by densito-metric detection at 230 nm. Derivative spectrophotometric determination of trimetazidine dihydrochloride is carried out from the fourth derivative of the absorbance at 233 nm in peak-zero mode. Statistical comparison led to the conclusion that there is no significant difference between the two studied methods and, moreover, that they demonstrate satisfactory accuracy and precision for routine applications.

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