pH-sensitive micelles self-assembled from multi-arm star triblock co-polymers poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery

2013 ◽  
Vol 9 (8) ◽  
pp. 7679-7690 ◽  
Author(s):  
You Qiang Yang ◽  
Bin Zhao ◽  
Zhen Dong Li ◽  
Wen Jing Lin ◽  
Can Yang Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Anticancer Drug ◽  
Methyl Ether ◽  
Ph Sensitive ◽  
Poly Ethylene Glycol ◽  
Ethyl Methacrylate ◽  
Anticancer Drug Delivery ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Facile construction of stabilized, pH-sensitive micelles based on cyclic statistical copolymers of poly(oligo(ethylene glycol)methyl ether methacrylate-st-N,N-dimethylaminoethyl methacrylate) for in vitro anticancer drug delivery

2020 ◽  
Vol 11 (38) ◽  
pp. 6139-6148
Author(s):  
Miao Zhang ◽  
Ying Liu ◽  
Jinlei Peng ◽  
Yuping Liu ◽  
Fangjun Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Anticancer Drug ◽  
Methyl Ether ◽  
Colloidal Stability ◽  
Ph Sensitive ◽  
Anticancer Drug Delivery ◽  
Dimethylaminoethyl Methacrylate ◽  
Glycol Methyl Ether

This study developed a facile approach to improve the colloidal stability of a cyclic polycation as well as presented a pH-sensitive cyclic copolymer-based nanoplatform with great potential for anticancer drug delivery.

The Influences of Monomer Structure and Solvent on the Radical Copolymerization of Tertiary Amine and PEGylated Methacrylates

2021 ◽  
Author(s):  
Priscila Quiñonez-Angulo ◽  
Robin Hutchinson ◽  
Angel Licea-Claverie ◽  
Enrique Saldivar ◽  
Ivan Zapata-Gonzalez
Keyword(s):  
Ethylene Glycol ◽  
Methyl Ether ◽  
Tertiary Amine ◽  
Radical Copolymerization ◽  
Poly Ethylene Glycol ◽  
Ethyl Methacrylate ◽  
Monomer Structure ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Tertiary Amine Methacrylates (TAMAs), such as 2-(N,N-diethylamino)ethyl methacrylate (DEAEMA) and 2-(N,N-dimethylamino)ethyl methacrylate (DMAEMA), and PEGylated (macro)monomers, such as 2-ethoxyethyl methacrylate (EEMA1) and poly(ethylene glycol) methyl ether methacrylates with 9 and...

scholarly journals Hybrid Mesoporous Silica Nanoparticles Grafted with 2-(tert-butylamino)ethyl Methacrylate-b-poly(ethylene Glycol) Methyl Ether Methacrylate Diblock Brushes as Drug Nanocarrier

Molecules ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 195 ◽  
Author(s):  
Abdullah M Alswieleh ◽  
Abeer M Beagan ◽  
Bayan M Alsheheri ◽  
Khalid M Alotaibi ◽  
Mansour D Alharthi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Ethylene Glycol ◽  
Silica Nanoparticles ◽  
Methyl Ether ◽  
Diblock Copolymer ◽  
Mesoporous Silica Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Ethyl Methacrylate ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

This paper introduces the synthesis of well-defined 2-(tert-butylamino)ethyl methacrylate-b-poly(ethylene glycol) methyl ether methacrylate diblock copolymer, which has been grafted onto mesoporous silica nanoparticles (PTBAEMA-b-PEGMEMA-MSNs) via atom transfer radical polymerization (ATRP). The ATRP initiators were first attached to the MSN surfaces, followed by the ATRP of 2-(tert-butylamino)ethyl methacrylate (PTBAEMA). CuBr2/bipy and ascorbic acid were employed as the catalyst and reducing agent, respectively, to grow a second polymer, poly(ethylene glycol) methyl ether methacrylate (PEGMEMA). The surface structures of these fabricated nanomaterials were then analyzed using Fourier Transform Infrared (FTIR) spectroscopy. The results of Thermogravimetric Analysis (TGA) show that ATRP could provide a high surface grafting density for polymers. Dynamic Light Scattering (DLS) was conducted to investigate the pH-responsive behavior of the diblock copolymer chains on the nanoparticle surface. In addition, multifunctional pH-sensitive PTBAEMA-b-PEGMEMA-MSNs were loaded with doxycycline (Doxy) to study their capacities and long-circulation time.

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

2015 ◽  
Vol 3 (7) ◽  
pp. 1105-1113 ◽  
Author(s):  
Rong Sun ◽  
Xiao-Jiao Du ◽  
Chun-Yang Sun ◽  
Song Shen ◽  
Yang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Polylactic Acid ◽  
Anticancer Drug ◽  
Poly Ethylene Glycol ◽  
Anticancer Drug Delivery ◽  
Poly Ethylene

Zwitterionic polyphosphoester containing polymers are synthesized and evaluated as an alternative to poly(ethylene glycol) block copolymers for anticancer drug delivery.

A pH-sensitive, strong double-network hydrogel: Poly(ethylene glycol) methyl ether methacrylates-poly(acrylic acid)

2011 ◽  
Vol 50 (6) ◽  
pp. 423-430 ◽  
Author(s):  
Sina Naficy ◽  
Joselito M. Razal ◽  
Philip G. Whitten ◽  
Gordon G. Wallace ◽  
Geoffrey M. Spinks
Keyword(s):  
Acrylic Acid ◽  
Ethylene Glycol ◽  
Methyl Ether ◽  
Ph Sensitive ◽  
Poly Ethylene Glycol ◽  
Double Network ◽  
Poly Ethylene ◽  
Glycol Methyl Ether ◽  
Poly Acrylic Acid
Sign in / Sign up

Export Citation Format

Share Document