Multilayer Injectable Hydrogel System Sequentially Delivers Bioactive Substances for Each Wound Healing Stage

2020 ◽  
Author(s):  
Zhijie Ma ◽  
Wei Song ◽  
Yaohua He ◽  
Haiyan Li
Keyword(s):  
Wound Healing ◽  
Bioactive Substances ◽  
Injectable Hydrogel ◽  
Hydrogel System

scholarly journals Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing

2020 ◽  
Author(s):  
Alexandr Basov ◽  
Liliya Fedulova ◽  
Ekaterina Vasilevskaya ◽  
Ekaterina Trofimova ◽  
Nataliya Murashova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sus Scrofa ◽  
Skin Wound ◽  
Bioactive Substances ◽  
Skin Wound Healing ◽  
Immune Tissues

Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment

2019 ◽  
Vol 7 (10) ◽  
pp. 4195-4207 ◽  
Author(s):  
Thai Minh Duy Le ◽  
Bo-Kyeong Jung ◽  
Yi Li ◽  
Huu Thuy Trang Duong ◽  
Thanh Loc Nguyen ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Temperature Responsive ◽  
Oncolytic Adenoviruses ◽  
Term Delivery ◽  
Physically Crosslinked ◽  
Hydrogel System

A dual pH- and temperature-responsive physically crosslinked and injectable hydrogel system was developed for efficient and long-term delivery of oncolytic adenoviruses (Ads).

Injectable hydrogel composed of hydrophobically modified chitosan/oxidized-dextran for wound healing

2019 ◽  
Vol 104 ◽  
pp. 109930 ◽  
Author(s):  
Xinchen Du ◽  
Yujie Liu ◽  
Xin Wang ◽  
Hongyu Yan ◽  
Lina Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Injectable Hydrogel ◽  
Oxidized Dextran ◽  
Modified Chitosan ◽  
Hydrophobically Modified

scholarly journals Effect of Oral Administration of Active Peptides of Pinctada Martensii on the Repair of Skin Wounds

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 697 ◽  
Author(s):  
Faming Yang ◽  
Xiaoming Qin ◽  
Ting Zhang ◽  
Chaohua Zhang ◽  
Haisheng Lin
Keyword(s):  
Amino Acids ◽  
Wound Healing ◽  
Clinical Problem ◽  
Skin Wound ◽  
Type Iii Collagen ◽  
Bioactive Substances ◽  
Skin Wound Healing ◽  
Active Peptides ◽  
Pinctada Martensii

Skin wound healing, especially chronic wound healing, is a common challenging clinical problem. It is urgent to broaden the sources of bioactive substances that can safely and efficiently promote skin wound healing. This study aimed to observe the effects of active peptides (APs) of the mantle of Pinctada martensii on wound healing. After physicochemical analysis of amino acids and mass spectrometry of APs, the effect of APs on promoting healing was studied through a whole cortex wound model on the back of mice for 18 consecutive days. The results showed that APs consisted of polypeptides with molecular weights in the range 302.17–2936.43 Da. The content of polypeptides containing 2–15 amino acids accounted for 73.87%, and the hydrophobic amino acids accounted for 56.51%. Results of in vitro experimentation showed that mice in APs-L group which were fed a low dose of APs (0.5 g/kg bw) had a shortened epithelialization time due to a shortening inflammatory period (p < 0.05). Mechanistically, this relied on its specific ability to promote the proliferation of CD31, FGF and EGF which accelerated the percentage of wound closure. Moreover, the APs-L group mice had enhanced collagen synthesis and increased type III collagen content in their wounds through a TGF-β/Smad signaling pathway (p > 0.05). Consequently, scar formation was inhibited and wound healing efficiency was significantly improved. These results show that the APs of Pinctada martensii promote dermal wound healing in mice and have tremendous potential for development and utilization in skin wound healing.

A novel injectable hydrogel system based on polyampholyte microgels

2017 ◽  
Vol 259 ◽  
pp. e101-e102
Author(s):  
Peijian Sun ◽  
Cong Nie ◽  
Zhihua Gan
Keyword(s):  
Injectable Hydrogel ◽  
Hydrogel System

scholarly journals Platelet Rich Plasma: a short overview of certain bioactive components

Open Medicine ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. 242-247 ◽  
Author(s):  
Voja Pavlovic ◽  
Milan Ciric ◽  
Vladimir Jovanovic ◽  
Predrag Stojanovic
Keyword(s):  
Wound Healing ◽  
Reference Data ◽  
Platelet Rich Plasma ◽  
Physiological Role ◽  
Potential Effect ◽  
Bioactive Components ◽  
Bioactive Substances ◽  
New Approach ◽  
Different Tissues

AbstractPlatelet rich plasma (PRP) represents a relatively new approach in regenerative medicine. It is obtained from patient’s own blood and contains different growth factors and other biomolecules necessary for wound healing. Since there are various protocols for PRP preparing, it usually results with PRP generation with different amounts of bioactive substances, which finally may modulate the intensity of wound healing. The reference data about potential effect of some PRP compounds on wound healing, in different tissues, are still controversial. This review summarizes recently known facts about physiological role of certain PRP components and guidance for further research. Also, this review discusses different procedure for PRP generation and potential effect of leukocytes on wound healing.

scholarly journals Advances in Skin Wound and Scar Repair by Polymer Scaffolds

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6110
Author(s):  
Shuiqing Zhou ◽  
Qiusheng Wang ◽  
Ao Huang ◽  
Hongdou Fan ◽  
Shuqin Yan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Drug Application ◽  
Surgical Excision ◽  
Skin Wound ◽  
Great Promise ◽  
Wound Healing Process ◽  
Polymer Scaffolds ◽  
Bioactive Substances ◽  
Cell Adhesion And Migration

Scars, as the result of abnormal wound-healing response after skin injury, may lead to loss of aesthetics and physical dysfunction. Current clinical strategies, such as surgical excision, laser treatment, and drug application, provide late remedies for scarring, yet it is difficult to eliminate scars. In this review, the functions, roles of multiple polymer scaffolds in wound healing and scar inhibition are explored. Polysaccharide and protein scaffolds, an analog of extracellular matrix, act as templates for cell adhesion and migration, differentiation to facilitate wound reconstruction and limit scarring. Stem cell-seeded scaffolds and growth factors-loaded scaffolds offer significant bioactive substances to improve the wound healing process. Special emphasis is placed on scaffolds that continuously release oxygen, which greatly accelerates the vascularization process and ensures graft survival, providing convincing theoretical support and great promise for scarless healing.

scholarly journals A Novel Effective Formulation of Bioactive Compounds for Wound Healing: Preparation, In Vivo Characterization, and Comparison of Various Postbiotics Cold Creams in a Rat Model

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Nasim Golkar ◽  
Yousef Ashoori ◽  
Reza Heidari ◽  
Navid Omidifar ◽  
Seyedeh Narjes Abootalebi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bacillus Subtilis ◽  
Lactobacillus Reuteri ◽  
Healing Process ◽  
Wound Healing Process ◽  
Sprague Dawley ◽  
Bioactive Substances ◽  
Cold Cream ◽  
Healing Property

The wound is a break in the integrity of the skin produced by injury, illness, or operation. Wound healing is an essential dynamic biological/physiological process that occurs in response to tissue damage. The huge health, economic, and social effects of wounds on patients and societies necessitate the research to find novel potential therapeutic agents in order to promote wound healing. Postbiotics, the newest member of the biotics family, are valuable functional bioactive substances produced by probiotics through their metabolic activity, which have several beneficial properties, including immunomodulatory, anti-inflammatory, antimicrobial, and angiogenesis characteristics, resulting in acceleration of wound healing. In the current study, three topical cold cream formulations containing postbiotics obtained from Lactobacillus fermentum, Lactobacillus reuteri, or Bacillus subtilis sp. natto probiotic strains were prepared. The effectiveness and wound healing activity of the developed postbiotics cold cream formulations were investigated compared to cold cream without postbiotics and no treatment via wound closure investigation, hydroxyproline content assay, and histological assessment in 25 Sprague Dawley rats divided into five groups. Interestingly, analysis of the results revealed that all three formulations containing postbiotics significantly accelerated the wound healing process. However, in general, the Bacillus subtilis natto cold cream manifested a better wound healing property. The pleasing wound healing characteristics of the topical postbiotics cold creams through the in vivo experiment suggest that formulations containing postbiotics can be considered as a promising nominee for wound healing approaches.

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