Corrigendum to ‘Ureter tissue engineering with vessel extracellular matrix and differentiated urine-derived stem cells’[Acta Biomaterialia 88 (2019), 266-279]

Modern medicine faces a growing crisis as demand for organ transplantations continues to far outstrip supply. By stimulating the body's own repair mechanisms, regenerative medicine aims to reduce demand for organs, while the closely related field of tissue engineering promises to deliver “of-the-self” organs grown from patients' own stem cells to improve supply. To deliver on these promises, we must have reliable means of generating complex tissues. Thus far, the majority of successful tissue engineering approaches have relied on macroporous scaffolds to provide cells with both mechanical support and differentiative cues. In order to engineer complex tissues, greater attention must be paid to nanoscale cues present in a cell's microenvironment. As the extracellular matrix is capable of driving complexity during development, it must be understood and reproduced in order to recapitulate complexity in engineered tissues. This review will summarize current progress in engineering complex tissue through the integration of nanocomposites and biomimetic scaffolds.

Download Full-text

Combining decellularized human adipose tissue extracellular matrix and adipose-derived stem cells for adipose tissue engineering

Acta Biomaterialia ◽

10.1016/j.actbio.2013.06.035 ◽

2013 ◽

Vol 9 (11) ◽

pp. 8921-8931 ◽

Cited By ~ 69

Author(s):

Lina Wang ◽

Joshua A. Johnson ◽

Qixu Zhang ◽

Elisabeth K. Beahm

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Extracellular Matrix ◽

Adipose Tissue ◽

Human Adipose Tissue ◽

Adipose Derived Stem Cells ◽

Adipose Tissue Engineering

Download Full-text

Vascular extracellular matrix and fibroblasts-coculture directed differentiation of human mesenchymal stem cells toward smooth muscle-like cells for vascular tissue engineering

Materials Science and Engineering C ◽

10.1016/j.msec.2018.07.061 ◽

2018 ◽

Vol 93 ◽

pp. 61-69 ◽

Cited By ~ 12

Author(s):

Na Li ◽

Hanna Sanyour ◽

Tyler Remund ◽

Patrick Kelly ◽

Zhongkui Hong

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Extracellular Matrix ◽

Mesenchymal Stem Cells ◽

Smooth Muscle ◽

Vascular Tissue ◽

Human Mesenchymal Stem Cells ◽

Vascular Tissue Engineering ◽

Directed Differentiation

Download Full-text

Mechanical and Chemical Stimulation of Bone-Marrow Stem Cells in a Three-Dimensional Fibrin Matrix: Preliminary Results

ASME 2008 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2008-193117 ◽

2008 ◽

Author(s):

Jessica L. LoSurdo ◽

Douglas W. Chew ◽

Alejandro Nieponice ◽

David A. Vorp

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Bone Marrow ◽

Extracellular Matrix ◽

Vascular Graft ◽

Three Dimensional ◽

Chemical Stimulation ◽

Alternative Source ◽

Immunological Rejection ◽

Stimulation Of

The primary goal of tissue engineering is to develop a biological, mechanically-robust, and anti-thrombogenic vascular graft to replace diseased or damaged tissue and organs [1]. For example, researchers have incorporated smooth muscle cells (SMCs) into extracellular matrix to provide a living, functional conduits with the intended purpose of replacing SMC-containing tubes, such as the blood vessel, urethra, esophagus, intestine, etc. Although the preferred source is autologous cells to avoid immunological rejection, adult SMCs are difficult to obtain and expand. An alternative source of autologous cells could be bone marrow derived stem cells (BMSCs), which differentiate toward mesenchymal and hematopoietic lineages [2].

Download Full-text

In VitroCartilage Tissue Engineering Using Adipose-Derived Extracellular Matrix Scaffolds Seeded with Adipose-Derived Stem Cells

Tissue Engineering Part A ◽

10.1089/ten.tea.2011.0103 ◽

2012 ◽

Vol 18 (1-2) ◽

pp. 80-92 ◽

Cited By ~ 35

Author(s):

Ji Suk Choi ◽

Beob Soo Kim ◽

Jae Dong Kim ◽

Young Chan Choi ◽

Hee Young Lee ◽

...

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Extracellular Matrix ◽

Adipose Derived Stem Cells ◽

Extracellular Matrix Scaffolds

Download Full-text

A functional extracellular matrix biomaterial enriched with VEGFA and bFGF as vehicle of human umbilical cord mesenchymal stem cells in skin wound healing

Biomedical Materials ◽

10.1088/1748-605x/ac37b0 ◽

2021 ◽

Author(s):

Zhongjuan Xu ◽

Junjun Cao ◽

Zhe Zhao ◽

Yong Qiao ◽

Xingzhi Liu ◽

...

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Extracellular Matrix ◽

Mesenchymal Stem Cells ◽

Umbilical Cord ◽

Limited Resource ◽

Host Cells ◽

Endothelial Differentiation ◽

Human Umbilical Cord ◽

Skin Wound Healing

Abstract The construction of microvascular network is one of the greatest challenges for tissue engineering and cell therapy. Endothelial cells are essential for the construction of network of blood vessels. However, their application meets challenges in clinic due to the limited resource of autologous endothelium. Mesenchymal stem cells (MSCs) can effectively promote the angiogenesis in ischemic tissues for their abilities of endothelial differentiation and paracrine, and abundant sources. Extracellular matrix (ECM) has been widely used as an ideal biomaterial to mimic cellular microenvironment for tissue engineering due to its merits of neutrality, good biocompatibility, degradability, and controllability. In this study, a functional cell derived ECM biomaterial enriched with VEGFA and bFGF by expressing the collagen-binding domain (CBD) fused factor genes in host cells was prepared. This material could induce endothelial differentiation of human umbilical cord mesenchymal stem cells (hUCMSCs) and promote angiogenesis, which may improve the healing effect of skin injury. Our research not only provides a functional ECM material to inducing angiogenesis by inducing endothelial differentiation of hUCMSCs, but also shed light on the ubiquitous approaches to endow ECM materials different functions by enriching different factors. This study will greatly benefit tissue engineering and regenerative medicine researches.

Download Full-text