Electrohydrodynamic atomization and spray-drying for the production of pure drug nanocrystals and co-crystals

2018 ◽  
Vol 131 ◽  
pp. 79-100 ◽  
Author(s):  
Roni Sverdlov Arzi ◽  
Alejandro Sosnik
Keyword(s):  
Spray Drying ◽  
Electrohydrodynamic Atomization ◽  
Pure Drug

scholarly journals FORMULATION AND CHARACTERIZATION OF HPMC AND HPMCAS BASED SOLID DISPERSIONS OF FENOFIBRATE: A COMPARATIVE STUDY

2019 ◽  
pp. 41-48 ◽  
Author(s):  
Ankit Rampal ◽  
Manmeet Singh ◽  
Shanta Mahajan ◽  
Neena Bedi
Keyword(s):  
Ir Spectroscopy ◽  
Optical Microscopy ◽  
Spray Drying ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Hydroxypropyl Methylcellulose ◽  
Pure Drug ◽  
Physical Mixtures ◽  
Spray Dried

Objective: The aim of the present study was to investigate the effect of novel polymeric carriers and to develop solid dispersion formulation that could improve in vitro profile of Fenofibrate (FB). Methods: Spray drying technique was used to fabricate solid dispersions with hydrophilic carriers, mainly hydroxypropyl methylcellulose (HPMC) and hydroxypropyl methylcellulose acetate succinate (HPMCAS). Solid dispersions in the form of spray-dried powder were characterized with respect to the pure drug and the corresponding physical mixtures by optical microscopy, x-ray diffraction (XRD), fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC). Size and morphology of optimized solid dispersion were performed by scanning electron microscopy (SEM). Furthermore, in vitro dissolution comparisons were carried out between the optimized solid dispersion against the pure drug and the physical mixtures. Results: Solubility studies demonstrated that the solubility of FB was not affected by pH change. The transformation of crystalline FB into an amorphous solid dispersion powder has been clearly demonstrated by optical microscopy. The molecular dispersion of drug in the dispersion matrix prepared by spray drying was confirmed in XRD and DSC studies. IR spectroscopy was observed with negligible incompatibility of the drug with polymers. Spherical morphology was observed in SEM with no evidence of FB crystals. The prepared solid dispersions exhibited dissolution improvement as compared to the pure drug and spray dried FB in 0.05 M SLS, with HPMCAS as the superior carrier over HPMC. Conclusion: The present study vouches better in vitro profile of FB from spray-dried HPMCAS based solid dispersions.

scholarly journals Silymarin-solid dispersions: Characterization and influence of preparation methods on dissolution

2010 ◽  
Vol 60 (4) ◽  
pp. 427-443 ◽  
Author(s):  
Dalwadi Sonali ◽  
Soni Tejal ◽  
Thakkar Vaishali ◽  
Gandhi Tejal
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Precipitation Method ◽  
Amorphous Solid Dispersion ◽  
Preparation Methods ◽  
Hydrogen Bond Formation ◽  
Pure Drug ◽  
Co Precipitation

Silymarin-solid dispersions: Characterization and influence of preparation methods on dissolution The influence of preparation methodology of silymarin solid dispersions using a hydrophilic polymer on the dissolution performance of silymarin was investigated. Silymarin solid dispersions were prepared using HPMC E 15LV by kneading, spray drying and co-precipitation methods and characterized by FTIR, DSC, XRPD and SEM. Dissolution profiles were compared by statistical and model independent methods. The FTIR and DSC studies revealed weak hydrogen bond formation between the drug and polymer, while XRPD and SEM confirmed the amorphous nature of the drug in co-precipitated solid dispersion. Enhanced dissolution compared to pure drug was found in the following order: co-precipitation > spray drying > kneading methodology (p < 0.05). All preparation methods enhanced silymarin dissolution from solid dispersions of different characteristics. The co-precipitation method proved to be best and provided a stable amorphous solid dispersion with 2.5 improved dissolution compared to the pure drug.

Preparation and Characterization of Monodispersed and Spherical YAG Powder for Transparent Ceramic by Spray Drying

2015 ◽  
Vol 30 (5) ◽  
pp. 487 ◽  
Author(s):  
ZHANG Le ◽  
ZHOU Tian-Yuan ◽  
YANG Hao ◽  
QIAO Xue-Bin ◽  
WANG Zhong-Ying ◽  
...  
Keyword(s):  
Spray Drying ◽  
Transparent Ceramic

OSA modified starch in lipid encapsulation by spray drying

2013 ◽  
pp. 45-61
Author(s):  
Ewa Domian ◽  
Ewa Świrydow ◽  
Jan Cenkier
Keyword(s):  
Spray Drying ◽  
Modified Starch

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

TEKNOLOGI PENANGANAN EMISI GAS DARI INSINERATOR SAMPAH KOTA

2019 ◽  
Vol 11 (2) ◽  
Author(s):  
Prasetiyadi Prasetiyadi ◽  
Wiharja Wiharja ◽  
Sri Wahyono
Keyword(s):  
Fly Ash ◽  
Pressure Drop ◽  
Spray Drying ◽  
Flue Gas ◽  
Bag Filter

Proses pembakaran sampah kota melalui insinerator akan menghasilkan uap panas yang bisa dimanfaatkan  untuk membangkitkan energi listrik, akan tetapi pada proses ini juga menghasilkan output berupa flue gas yang didominasi oleh partikel (fly ash) dan gas beracun seperti: HCl, SO2, NOx, HF, Hg, Cd dan Dioxin. Sebelum dibuang ke udara bebas, flue gas tersebut harus diolah agar memenuhi baku mutu lingkungan. Teknologi penanganan partikel dan gas polutan tersedia dan dapat dibuat dengan berbagai kapasitas. Untuk menangani flue gas dari insinerator sampah digunakan Quencher untuk menekan laju pembentukan kembali dioksin dan furan setelah proses pembakaran,  Spray Drying Absorption (SDA) untuk mengikat gas asam dan  logam berat serta bag filter untuk menangkap partikel. Selain itu digunakan ID Fan dan Cerobong Asap untuk pengatasi pressure drop yang terjadi akibat pengoperasian peralatan APC dan melepas ke udara.

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