Comparative Study of Cerebral Blood Flow in Patients With Normal-tension Glaucoma and Control Subjects

2006 ◽  
Vol 141 (2) ◽  
pp. 394-396 ◽  
Author(s):  
Tetsuya Sugiyama ◽  
Keita Utsunomiya ◽  
Hitoya Ota ◽  
Yasuharu Ogura ◽  
Isamu Narabayashi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Comparative Study ◽  
Normal Tension Glaucoma ◽  
Control Subjects ◽  
And Control

scholarly journals Interictal cortical hyperresponsiveness in migraine is directly related to the presence of aura

Cephalalgia ◽  
2013 ◽  
Vol 33 (6) ◽  
pp. 365-374 ◽  
Author(s):  
Ritobrato Datta ◽  
Geoffrey K Aguirre ◽  
Siyuan Hu ◽  
John A Detre ◽  
Brett Cucchiara
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Visual Stimulus ◽  
Visual Stimulation ◽  
Blood Oxygen Level Dependent ◽  
Blood Oxygen Level ◽  
Visual Discomfort ◽  
Bold Fmri ◽  
Control Subjects ◽  
And Control

Objective The objective of this study was to compare the interictal cortical response to a visual stimulus between migraine with aura (MWA), migraine without aura (MwoA), and control subjects. Methods In a prospective case-control study, blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) was used to assess the response to a visual stimulus and arterial spin labeled perfusion MR to determine resting cerebral blood flow. A standardized questionnaire was used to assess interictal visual discomfort. Results Seventy-five subjects (25 MWA, 25 MwoA, and 25 controls) were studied. BOLD fMRI response to visual stimulation within primary visual cortex was greater in MWA (3.09 ± 0.15%) compared to MwoA (2.36 ± 0.13%, p = 0.0008) and control subjects (2.47 ± 0.11%, p = 0.002); responses were also greater in the lateral geniculate nuclei in MWA. No difference was found between MwoA and control groups. Whole brain analysis showed that increased activation in MWA was confined to the occipital pole. Regional resting cerebral blood flow did not differ between groups. MWA and MwoA subjects had significantly greater levels of interictal visual discomfort compared to controls ( p = 0.008 and p = 0.005, respectively), but this did not correlate with BOLD response. Conclusions Despite similar interictal symptoms of visual discomfort, only MWA subjects have cortical hyperresponsiveness to visual stimulus, suggesting a direct connection between cortical hyperresponsiveness and aura itself.

Early Evidence of Sepsis-Associated Hyperperfusion—A Study of Cerebral Blood Flow Measured With MRI Arterial Spin Labeling in Critically Ill Septic Patients and Control Subjects*

2018 ◽  
Vol 46 (7) ◽  
pp. e663-e669 ◽  
Author(s):  
Marie-Hélène Masse ◽  
Marie Anne Richard ◽  
Frédérick D’Aragon ◽  
Charles St-Arnaud ◽  
Michael Mayette ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Critically Ill ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Control Subjects ◽  
Early Evidence ◽  
And Control

scholarly journals Cerebral blood flow increases during insulin-induced hypoglycaemia in Type 1 (insulin-dependent) diabetic patients and control subjects

Diabetologia ◽  
1987 ◽  
Vol 30 (5) ◽  
pp. 305-309 ◽  
Author(s):  
H. A. W. Neil ◽  
E. A. M. Gale ◽  
S. J. C. Hamilton ◽  
I. Lopez-Espinoza ◽  
R. Kaura ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Diabetic Patients ◽  
Control Subjects ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
And Control

scholarly journals Cerebral blood flow in children with syndromic craniosynostosis: cohort arterial spin labeling studies

2020 ◽  
Vol 25 (4) ◽  
pp. 340-350 ◽  
Author(s):  
Priya N. Doerga ◽  
Maarten H. Lequin ◽  
Marjolein H. G. Dremmen ◽  
Bianca K. den Ottelander ◽  
Katya A. L. Mauff ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Convenience Sample ◽  
Control Subjects ◽  
Syndromic Craniosynostosis ◽  
Development Change ◽  
And Control ◽  
Neurological Pathology

OBJECTIVEIn comparison with the general population, children with syndromic craniosynostosis (sCS) have abnormal cerebral venous anatomy and are more likely to develop intracranial hypertension. To date, little is known about the postnatal development change in cerebral blood flow (CBF) in sCS. The aim of this study was to determine CBF in patients with sCS, and compare findings with control subjects.METHODSA prospective cohort study of patients with sCS using MRI and arterial spin labeling (ASL) determined regional CBF patterns in comparison with a convenience sample of control subjects with identical MRI/ASL assessments in whom the imaging showed no cerebral/neurological pathology. Patients with SCS and control subjects were stratified into four age categories and compared using CBF measurements from four brain lobes, the cerebellum, supratentorial cortex, and white matter. In a subgroup of patients with sCS the authors also compared longitudinal pre- to postoperative CBF changes.RESULTSSeventy-six patients with sCS (35 female [46.1%] and 41 male [53.9%]), with a mean age of 4.5 years (range 0.2–19.2 years), were compared with 86 control subjects (38 female [44.2%] and 48 male [55.8%]), with a mean age of 6.4 years (range 0.1–17.8 years). Untreated sCS patients < 1 year old had lower CBF than control subjects. In older age categories, CBF normalized to values observed in controls. Graphical analyses of CBF by age showed that the normally expected peak in CBF during childhood, noted at 4 years of age in control subjects, occurred at 5–6 years of age in patients with sCS. Patients with longitudinal pre- to postoperative CBF measurements showed significant increases in CBF after surgery.CONCLUSIONSUntreated patients with sCS < 1 year old have lower CBF than control subjects. Following vault expansion, and with age, CBF in these patients normalizes to that of control subjects, but the usual physiological peak in CBF in childhood occurs later than expected.

scholarly journals Cerebral Blood Flow in Patients with Intracranial Pressure Elevation due to Traumatic Brain Edema

1976 ◽  
Vol 3 (1) ◽  
pp. 35-37 ◽  
Author(s):  
W. A. Tweed ◽  
Jørn Overgaard
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Intracranial Pressure ◽  
Brain Edema ◽  
Cerebral Perfusion ◽  
Perfusion Pressure ◽  
Monitoring And Control ◽  
Intracranial Pressure Elevation ◽  
Flow Through ◽  
And Control

SUMMARY:The object of this study was to determine if traumatic brain edema (BE) and increased intracranial pressure (ICP) reduce cerebral blood flow (CBF). Two groups of patients were studied, one with slight BE and ICP less than 20 mm Hg., the other with pronounced BE and ICP over 20 mm Hg. Although ICP was higher and cerebral perfusion pressure lower in pro-nounced edema there was only a small and non-significant reduction in CBF and no difference in cerebro-vascular resistance. Since traumatic BE does not increase resistance to blood flow through the brain, cerebral perfusion can be maintained if an adequate perfusion pressure is established. This in turn, demands the monitoring and control of ICP.

Impaired sympathetic regulation of cerebral blood flow in patients with cirrhosis of the liver

2002 ◽  
Vol 103 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Alfonso LAGI ◽  
Giacomo LAFFI ◽  
Simone CENCETTI ◽  
Giuseppe BARLETTA ◽  
Marco FOSCHI ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Circulation ◽  
Cerebral Blood Flow Velocity ◽  
Bivariate Analysis ◽  
Lag Phase ◽  
Inadequate Response ◽  
Control Subjects ◽  
Baroreceptor Stimulation ◽  
Sympathetic Regulation

Continuous recording of mean cerebral blood flow velocity (MCBFV) by Doppler ultrasound allows detection of low-frequency (LF) oscillations, which reflect sympathetic activity in the cerebral circulation. To establish whether the sympathetic drive to the cerebral circulation is altered in patients with compensated cirrhosis, and, if so, where alterations take place, LF oscillations of MCBFV, heart rate (RR interval) and systolic arterial pressure (SAP) were analysed in 10 patients with cirrhosis and 10 control subjects during supine rest and on stimulation of carotid baroreceptors using a neck chamber applying sinusoidal suction. Bivariate analysis was used to study the relationship between pairs of oscillations. In the case of a significant association, the delay in the appearance of the oscillation in MCBFV, SAP and RR was calculated. Baroreceptor stimulation induced significant increases in SAP LF and RR LF power in both groups, while MCBFV LF power increased only in controls. During baroreceptor stimulation, the lag phase between SAP LF and MCBFV LF power was significantly lower in cirrhotic patients than in control subjects (0.96 compared with 1.59 rad; P<0.01), indicating altered sympathetic regulation of the cerebral circulation. The baroreflex arc was intact, as indicated by the similar pattern of RR-SAP interval in patients and controls. Plasma noradrenaline levels increased significantly in both groups in response to head-up tilt. These results indicate that patients with cirrhosis have an altered sympathetic regulation of the cerebral circulation that is characterized by an inadequate response of resistance microvessels, despite adequate baroreceptor function.

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