Association Between Platelet Function and Disc Hemorrhage in Patients With Normal-Tension Glaucoma: A Prospective Cross-Sectional Study

Background/Aims: Optic disc hemorrhage (DH) is an important glaucoma risk factor, and occurs in a wide intraocular pressure (IOP) range. We sought to characterize distinct clinical subtypes of patients with high- (HTDH) and low-tension DHs (LTDH). Methods: In this cross-sectional study, treated glaucomatous patients with DHs from two Glaucoma Services were consecutively enrolled. Disc photographs were evaluated for the presence of DH by two glaucoma specialists. After inclusion, patients were classified on HTDH (IOP≥16mmHg) and LTDH (IOP<16mmHg; median split). Clinical and ocular data from the time of DH detection were compared between groups. Results: One hundred thirty-three DH patients were included (LTDH=66 eyes; HTDH=67 eyes). Patients with LTDH were more often women than those with HTDH (77% vs 42%; p=0.030). There was also a trend for a higher prevalence of Asian descendants (24% vs 9%; p=0.058) and symptoms suggestive of vascular dysregulation (34% vs 14%; p=0.057) in LTDH patients. Eyes with LTDH also had worse visual field (VF) mean deviation index (p=0.037), higher prevalence of normal-tension glaucoma (NTG) diagnosis (46% vs 17%; p<0.001) and tended to have thinner central corneas (p=0.066). Conclusion: Patients developing DHs with treated IOPs in the low teens seem to more frequently fit in a profile represented by women, NTG diagnosis and greater VF loss. The presence of symptoms suggestive of vascular dysregulation and race also seem to differ between these two clinical subtypes. A closer optic disc surveillance is recommended for patients with the LTDH subtype, as they may develop DHs despite seemingly well-controlled IOP.

Download Full-text

Visual Field Changes in Normal Tension Glaucoma (NTG)

10.53350/pjmhs211592266 ◽

2021 ◽

Vol 15 (9) ◽

pp. 2266-2267

Author(s):

Ossama Ali Khan ◽

Sajjad Mohammad ◽

Imran Khan ◽

Muhammad Faiq Nisar ◽

Amir Khan ◽

...

Keyword(s):

Visual Field ◽

Open Angle Glaucoma ◽

Visual Fields ◽

Normal Tension Glaucoma ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Medical College ◽

Paracentral Scotoma ◽

The Right

Aim: To observe the visual field changes in normal tension glaucoma Study design: Cross sectional study Study site: Department of Physiology, Khyber Medical College, Peshawar Study period: six months Sample size: 100 cases were included who fulfil the criteria. Results: There were 33(33%) males and 67(67%) females in the study. Visual fields of eyes were investigated. It was revealed that in cases with the right eye problem, 67(67%) had paracentral scotoma, 27(27%) had superior & inferior nasal steps, 1(1%) had scotoma closer to fixation and 5(5%) had arcuate scotoma, while in the left eye cases, 67(67%) had paracentral scotoma, 30 (30%) had superior & inferior nasal steps, 1(1%) had scotoma closer to fixation and 2(2%) had arcuate scotoma. Conclusion: Visual fields of eyes revealed that in cases with the right eye problem, 67(67%) had paracentral scotoma, 27(27%) had superior & inferior nasal steps, 1(1%) had scotoma closer to fixation and 5(5%) had arcuate scotoma, while in the left eye cases, 67(67%) had paracentral scotoma, 30(30%) had superior & inferior nasal steps, 1 (1%) had scotoma closer to fixation and 2(2%) had arcuate scotoma. Keywords: Visual field, open angle glaucoma, normal tension glaucoma

Download Full-text

Central corneal thickness and normal tension glaucoma: A cross-sectional study

Optometry - Journal of the American Optometric Association ◽

10.1016/j.optm.2005.12.013 ◽

2006 ◽

Vol 77 (3) ◽

pp. 134-140 ◽

Cited By ~ 7

Author(s):

Michael Sullivan-Mee ◽

Kathy D. Halverson ◽

Mollie C. Saxon ◽

Glenn B. Saxon ◽

Clifford Qualls

Keyword(s):

Central Corneal Thickness ◽

Corneal Thickness ◽

Normal Tension Glaucoma ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Optic disc hemorrhage in nonglaucomatous eyes: A cross-sectional study with average 8-year follow-up

PLoS ONE ◽

10.1371/journal.pone.0237796 ◽

2020 ◽

Vol 15 (8) ◽

pp. e0237796

Author(s):

Yeo-Yang Koh ◽

Chi-Chun Lai ◽

Henry S. L. Chen ◽

Ling Yeung ◽

Wan-Chen Ku ◽

...

Keyword(s):

Optic Disc ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Disc Hemorrhage

Download Full-text

Ophthalmoscopic Changes of Normal Tension Glaucoma: A Study in Peshawar

10.53350/pjmhs211592264 ◽

2021 ◽

Vol 15 (9) ◽

pp. 2264-2265

Author(s):

Muhammad Faiq Nisar ◽

Sajjad Mohammad ◽

Imran Khan ◽

Ossama Ali Khan ◽

Amir Khan ◽

...

Keyword(s):

Sample Size ◽

Study Design ◽

Open Angle Glaucoma ◽

Normal Tension Glaucoma ◽

Cross Sectional Study ◽

Open Angle ◽

Sectional Study ◽

Cross Sectional ◽

Medical College ◽

Direct Ophthalmoscopy

Aim: To determine the ophthalmoscopic findings of normal tension glaucoma. Study design: This is a cross sectional study Study site: Department of Physiology, Khyber Medical College, Peshawar. Study period: six months Sample size: One hundred cases were selected. Results: In this study, 33(33%) males and 67(67%) females. On direct ophthalmoscopy, in right eye glaucoma, there were 93(93%) cases with cupped discs, while 7(7%) had gross cupping of the discs. In left eye glaucoma, there were 98(98%) cases who had cupped discs, while 2(2%) had gross cupping of the discs. Conclusion: On direct ophthalmoscopy, there were 93(93%) cases who had cupped discs in right eye glaucoma. Keywords: Ophthalmoscope examination, open angle glaucoma, normal tension glaucoma

Download Full-text

Optic Disc Hemorrhage after Phacoemulsification in Patients with Glaucoma

ISRN Ophthalmology ◽

10.1155/2014/574054 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Karine D. Bojikian ◽

Daniel B. Moore ◽

Philip P. Chen ◽

Mark A. Slabaugh

Keyword(s):

Optic Disc ◽

Pressure Fluctuations ◽

Cross Sectional Study ◽

Clinic Visit ◽

Optic Disk ◽

Slit Lamp ◽

Sectional Study ◽

Cross Sectional ◽

Disc Hemorrhage ◽

Slit Lamp Biomicroscopy

Background. Optic disk hemorrhage is known to be a risk factor for glaucoma progression. Cataract surgery by phacoemulsification results in large intraocular pressure fluctuations. We aim to investigate whether phacoemulsification is associated with optic disc hemorrhage in patients with glaucoma. Methods. This is a retrospective review of consecutive university clinic based glaucoma patients undergoing phacoemulsification alone, with at least 3 visits in the year before and at least 5 visits in the year following phacoemulsification. The presence of optic disk hemorrhage was evaluated with slit lamp biomicroscopy at each clinic visit prior to and following phacoemulsification. Results. We evaluated 158 eyes of 158 subjects; 15 (9.5%) had ODH noted at least once during the 2-year study period. Four eyes had ODH identified on postoperative day 1, for a cross-sectional prevalence of 2.5%. Fourteen ODH episodes were noted preoperatively versus 12 episodes postoperatively (P=0.68). Aspirin use was associated with ODH (P=0.015). Conclusions. Our cross-sectional study found a prevalence of ODH immediately after CE that was similar to other published rates, and our longitudinal study did not find an increase in ODH in the year after phacoemulsification when compared to the year prior to surgery.

Download Full-text

Ocular findings in patients with novel A/H1N1 infection: an observational cross-sectional study

F1000Research ◽

10.12688/f1000research.18927.1 ◽

2019 ◽

Vol 8 ◽

pp. 738

Author(s):

Salil Mehta ◽

Conrad Rui Vas

Keyword(s):

Retrospective Study ◽

H1n1 Influenza ◽

Cross Sectional Study ◽

Macular Area ◽

H1n1 Infection ◽

Sectional Study ◽

Cross Sectional ◽

Disc Hemorrhage ◽

Large Disc ◽

Ocular Lesions

Background: The systemic findings of novel A (H1N1) influenza have been well documented but data on ocular lesions is scarce. We report the systemic and ophthalmoscopic findings of 14 patients with proven H1N1 infection. Methods: An observational non-interventional retrospective study. During a period of nine years, 14 patients (six female and eight males), were referred for an ophthalmic evaluation. All patients underwent a detailed systemic and ocular evaluation. Results: Three patients (21.4 %) showed ocular lesions in the form of a unilateral intraretinal hemorrhage. Of these, one patient (7.1%) had a large disc hemorrhage and an area of retinal whitening, consistent with ischemia in the macular area. Conclusions: Physicians dealing with H1N1 infection should be aware of these findings and may include an ocular evaluation as part of their protocol.

Download Full-text