scholarly journals Visual Function and Disability Are Associated with Increased Retinal Volumetric Vessel Density in Patients with Multiple Sclerosis

2020 ◽  
Vol 213 ◽  
pp. 34-45 ◽  
Author(s):  
Hong Jiang ◽  
Giovana Rosa Gameiro ◽  
Yi Liu ◽  
Ying Lin ◽  
Jeffrey Hernandez ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Visual Function ◽  
Vessel Density

scholarly journals Longitudinal Evaluation of Visual Function in Multiple Sclerosis

2015 ◽  
Vol 92 (10) ◽  
pp. 976-985 ◽  
Author(s):  
Divya Narayanan ◽  
Han Cheng ◽  
Rosa A. Tang ◽  
Laura J. Frishman
Keyword(s):  
Multiple Sclerosis ◽  
Visual Function ◽  
Longitudinal Evaluation

scholarly journals Campimetry changes, optical coherence tomography and visual function changes in patients with multiple sclerosis

2017 ◽  
Vol 76 (3) ◽  
Author(s):  
Régia Bentes de Souza ◽  
Juliana Tessari Dias Rohr ◽  
Ronaldo Maciel Dias ◽  
Milena Magalhães Lima
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Visual Function ◽  
Optical Coherence

scholarly journals Retinal and Choriocapillary Vascular Changes in Early Stages of Multiple Sclerosis: A Prospective Study

2021 ◽  
Vol 10 (24) ◽  
pp. 5756
Author(s):  
Daniela Montorio ◽  
Roberta Lanzillo ◽  
Antonio Carotenuto ◽  
Maria Petracca ◽  
Marcello Moccia ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Retinal Vessel ◽  
Vessel Density ◽  
Ganglion Cell Complex ◽  
Healthy Controls ◽  
Fiber Layer ◽  
Density Reduction ◽  
Capillary Plexus ◽  
Retinal Vessel Density ◽  
A Prospective Study

Optical Coherence Tomography Angiography (OCTA) abnormalities occur in multiple sclerosis (MS) over the course of the disease. OCTA investigations at early MS stages are lacking. We aimed to investigate vessel density in macular and papillary regions over two years after an initial demyelinating event (IDE). Vessel density was analyzed in superficial, deep, choriocapillaris and radial peripapillary plexus at baseline, and after one and two years. We also evaluated structural OCT parameter changes of the ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). We evaluated 30 eyes from 15 IDE patients (7 females, 8 males, mean age 28.4 ± 9.6 years) and 30 eyes from 15 healthy controls. After 2 years, we reported in the IDE group a reduced vessel density in the superficial capillary plexus, deep capillary plexus and radial peripapillary capillary plexus with respect to the baseline (coeff. β = −2.779, p = 0.013; coeff. β = −4.055, p = 0.018 and coeff. β = −2.687, p ≤ 0.001; respectively), while GCC and RNFL thicknesses did not change. Vessel density reduction was not associated with an expanded disability status scale (EDSS) change, relapse occurrence or magnetic resonance imaging activity. The analysis of healthy controls did not reveal any impairment in OCT and OCTA parameters over 2 years of follow-up. Retinal vascular loss occurs in patients with an IDE independently from clinical and radiological disease activity. Retinal vessel density could represent a novel early biomarker to monitor the MS pathological burden.

Self-reported visual dysfunction in multiple sclerosis: results from the 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25)

2000 ◽  
Vol 6 (6) ◽  
pp. 382-385 ◽  
Author(s):  
Laura J Balcer ◽  
Monika L Baier ◽  
Amy M Kunkle ◽  
Richard A Rudick ◽  
Bianca Weinstock-Guttman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Visual Function ◽  
Reference Group ◽  
Clinical Manifestations ◽  
Phase Iii ◽  
Eye Disease ◽  
Visual Dysfunction ◽  
Scale Scores ◽  
Visual Function Questionnaire ◽  
Composite Scores

Visual impairment is one of the most common clinical manifestations of Multiple Sclerosis (MS), and is strongly related to overall health-related quality of life (HRQOL) in MS and other disorders. However, the assessment of vision-specific HRQOL in patients with MS has been limited. The purpose of this study was to examine self-reported visual dysfunction in a clinically heterogeneous MS cohort using the 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25). The VFQ-25 was administered by telephone interview to a subset of participants in a follow-up study to a phase III trial of interferon β-1a for relapsing-remitting MS. Mean VFQ-25 composite scores and selected sub-scale scores were significantly lower (worse) among patients in our MS cohort (n=35) compared with a published reference group of patients with no history of chronic eye disease (n=118). These differences were observed despite a relatively younger age and tighter distribution of binocular visual acuities in the MS cohort. Patients with MS in this study thus demonstrated a greater degree of self-reported visual dysfunction, as measured by the VFQ-25, compared with an eye disease-free reference group. The VFQ-25 is a potentially useful measure of vision-specific HRQOL in patients with MS.

scholarly journals The electrophysiological assessment of visual function in Multiple Sclerosis

2019 ◽  
Vol 4 ◽  
pp. 90-96 ◽  
Author(s):  
Joshua L. Barton ◽  
Justin Y. Garber ◽  
Alexander Klistorner ◽  
Michael H. Barnett
Keyword(s):  
Multiple Sclerosis ◽  
Visual Function

Acute effects of oral phosphate on visual function in multiple sclerosis

Neurology ◽  
1974 ◽  
Vol 24 (7) ◽  
pp. 601-601 ◽  
Author(s):  
F. O. BECKER ◽  
J. A. MICHAEL ◽  
F. A. DAVIS
Keyword(s):  
Multiple Sclerosis ◽  
Visual Function ◽  
Acute Effects

scholarly journals Optical Coherence Tomography and Optical Coherence Tomography Angiography Findings After Optic Neuritis in Multiple Sclerosis

2020 ◽  
Vol 11 ◽  
Author(s):  
Olwen C. Murphy ◽  
Grigorios Kalaitzidis ◽  
Eleni Vasileiou ◽  
Angeliki G. Filippatou ◽  
Jeffrey Lambe ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Visual Function ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Mixed Effect ◽  
Retinal Microvasculature ◽  
History Of

Background: In people with multiple sclerosis (MS), optic neuritis (ON) results in inner retinal layer thinning, and reduced density of the retinal microvasculature.Objective: To compare inter-eye differences (IEDs) in macular optical coherence tomography (OCT) and OCT angiography (OCTA) measures in MS patients with a history of unilateral ON (MS ON) vs. MS patients with no history of ON (MS non-ON), and to assess how these measures correlate with visual function outcomes after ON.Methods: In this cross-sectional study, people with MS underwent OCT and OCTA. Superficial vascular plexus (SVP) density of each eye was quantified using a deep neural network. IEDs were calculated with respect to the ON eye in MS ON patients, and with respect to the right eye in MS non-ON patients. Statistical analyses used mixed-effect regression models accounting for intra-subject correlations.Results: We included 43 MS ON patients (with 92 discrete OCT/OCTA visits) and 14 MS non-ON patients (with 24 OCT/OCTA visits). Across the cohorts, mean IED in SVP density was −2.69% (SD 3.23) in MS ON patients, as compared to 0.17% (SD 2.39) in MS non-ON patients (p = 0.002). When the MS ON patients were further stratified according to time from ON and compared to MS non-ON patients with multiple cross-sectional analyses, we identified that IED in SVP density was significantly increased in MS ON patients at 1–3 years (p = < 0.001) and >3 years post-ON (p < 0.001), but not at <3 months (p = 0.21) or 3–12 months post-ON (p = 0.07), while IED in ganglion cell + inner plexiform layer (GCIPL) thickness was significantly increased in MS ON patients at all time points post-ON (p ≦ 0.01 for all). IED in SVP density and IED in GCIPL thickness demonstrated significant relationships with IEDs in 100% contrast, 2.5% contrast, and 1.25% contrast letter acuity in MS ON patients (p < 0.001 for all).Conclusions: Our findings suggest that increased IED in SVP density can be detected after ON in MS using OCTA, and detectable changes in SVP density after ON may occur after changes in GCIPL thickness. IED in SVP density and IED in GCIPL thickness correlate well with visual function outcomes in MS ON patients.

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