Is meconium-stained amniotic fluid in near-term infants associated with increased rates of adverse maternal and neonatal outcomes?

Urinary concentrations of β2-microglobulin (β2M) and creatinine were measured in normal term infants and in those born with meconium-stained amniotic fluid. None of the infants or their mothers had conditions known to modify β2M excretion. Measurements of β2M were made on urines collected by bagging; urines obtained from diapers were not satisfactory. Urinary β2M concentrations increased significantly (P < .02) in the normal infants from the first day (0.36 ± 0.29 mg/L: n = 29) to the third day (0.60 ± 0.43 mg/L: n = 21) postpartum. Compared with the normal infants, values for the infants with meconium-stained amniotic fluid were increased significantly on days 1 (1.64 ± 2.16 mg/L: n = 25: P < .005) and 3 (2.12 ± 2.04 mg/L: n = 23: P < .005). Levels exceeded two standard deviations above the normal mean in 12 of the 26 infants with meconium-stained amniotic fluid on postpartum day 1, and 12 of the 23 infants with meconium-stained amniotic fluid on day 3. Urinary creatinine levels were similar in both the normal infants and those with meconium-stained amniotic fluid. All infants with meconium-stained amniotic fluid with a one-minute Apgar score of 6 or less had an elevated urinary β2M concentration. The elevated levels of urinary β2M in infants with meconium-stained amniotic fluid indicate the existence of tubular dysfunction, probably mild acute tubular necrosis secondary to hypoxia.

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Amniotic fluid embolism-risk factors, maternal and neonatal outcomes

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767050902787216 ◽

2009 ◽

Vol 22 (5) ◽

pp. 439-444 ◽

Cited By ~ 11

Author(s):

Michail Spiliopoulos ◽

Isha Puri ◽

Neetu J. Jain ◽

Lakota Kruse ◽

Dimitrios Mastrogiannis ◽

...

Keyword(s):

Risk Factors ◽

Amniotic Fluid ◽

Neonatal Outcomes ◽

Amniotic Fluid Embolism ◽

Maternal And Neonatal Outcomes

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Association of gestational age, Apgar score and neonatal outcomes in newborns with meconium stained amniotic fluid

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20192755 ◽

2019 ◽

Vol 6 (4) ◽

pp. 1563

Author(s):

Preeti Garg ◽

Devendra Barua ◽

Shruti Saxena

Keyword(s):

Amniotic Fluid ◽

Gestational Age ◽

Apgar Score ◽

Tertiary Care ◽

Neonatal Outcomes ◽

Control Group ◽

Study Group ◽

Increased Risk ◽

The Mean ◽

Meconium Stained Amniotic Fluid

Background: Infants born with meconium stained fluid are at increased risk of fetal hypoxia, evidenced by increased rates of abnormalities indicated by fetal monitoring in labor, low neonatal Apgar scores, and fetal deaths. The study is conducted to determine association of gestational age, Apgar score and neonatal outcomes in newborn born with meconium stained amniotic fluid in tertiary care centre of central India.Methods: The study was conducted over a period of 2 years from January 2012 to January 2014 in Department of Pediatrics, Sri Aurobindo Medical College and Hospital, Indore, Madhya Pradesh, India. One hundred newborns with meconium stained amniotic fluid (study group) and one hundred newborns with clear amniotic fluids (control group) were studied in this period. Gestational age, Apgar score and neonatal outcomes were compared among two groups.Results: The mean gestational age in study group was 38.89±1.14 weeks and in control group was 38.59±0.99 weeks. The mean Apgar score at 1 min was 5.80±1.59 in study group and in the control group was 7.86±0.35. 32 babies in meconium stained liquor had hypoxia of which 11 had respiratory distress, 11 required mechanical ventilation (MAS 08, sepsis 03), 2 newborns had HIE stage 2 and 5 patients died. The above findings suggest higher gestational age, lower Apgar score and poor neonatal outcomes are associated with meconium stained liquor.Conclusions: The study depicts significant co-relation with higher gestational age, lower Apgar at 1 and 5 minutes and poor neonatal outcome in babies with meconium stained amniotic fluid.

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Adrenocorticotropic hormone and cortisol levels in term infants born with meconium-stained amniotic fluid

Journal of Perinatal Medicine ◽

10.1515/jpm-2014-0244 ◽

2014 ◽

Vol 42 (6) ◽

Cited By ~ 2

Author(s):

Kaninghat Prasanth ◽

Medha Kamat ◽

Manhal Khilfeh ◽

Vanessa Davis

Keyword(s):

Respiratory Distress ◽

Amniotic Fluid ◽

Cord Blood ◽

Adrenocorticotropic Hormone ◽

Inadequate Response ◽

Term Infants ◽

Group 3 ◽

Cortisol Levels ◽

Group 2 ◽

Meconium Stained Amniotic Fluid

AbstractTo evaluate cord blood concentrations of adrenocorticotropic hormone (ACTH) and cortisol in well term infants born with and without meconium-stained amniotic fluid (MSAF) and term infants born with MSAF who experienced respiratory distress (RD).This was a prospective observational study. Fifty-four term infants were enrolled in the study in three groups: group 1 consisted of 18 well infants who were born with clear amniotic fluid, group 2 had 18 well infants born with MSAF, and group 3 had 18 infants born with MSAF who experienced RD in the first 24 h of age. Cord blood ACTH and cortisol concentrations were measured in infants born in all three groups. Groups 2 and 3 had serum ACTH and cortisol levels re-measured at 22–26 h of age.The mean ACTH and cortisol levels at birth in group 3 infants were 18.3 pg/mL and 12.6 mg/dL, respectively. These were significantly lower than those in group 2 infants.Term infants born with MSAF and who experienced respiratory distress had significantly lower levels of ACTH and cortisol at birth compared with well term infants born with MSAF or clear amniotic fluid. This study suggests that inadequate response of ACTH and cortisol hormones may play a role in the development of respiratory distress in term infants with MSAF.

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