Urinary β2-Microglobulin in Full-Term Newborns: Evidence for Proximal Tubular Dysfunction in Infants With Meconium-Stained Amniotic Fluid

PEDIATRICS ◽  
1985 ◽  
Vol 76 (6) ◽  
pp. 958-964 ◽  
Author(s):  
J. W. Cole ◽  
R. J. Portman ◽  
Y. Lim ◽  
J. M. Perlman ◽  
A. M. Robson
Keyword(s):  
Amniotic Fluid ◽  
Tubular Dysfunction ◽  
Term Infants ◽  
Β2 Microglobulin ◽  
Tubular Necrosis ◽  
Normal Term ◽  
Normal Mean ◽  
Proximal Tubular ◽  
Term Newborns ◽  
Meconium Stained Amniotic Fluid

Urinary concentrations of β2-microglobulin (β2M) and creatinine were measured in normal term infants and in those born with meconium-stained amniotic fluid. None of the infants or their mothers had conditions known to modify β2M excretion. Measurements of β2M were made on urines collected by bagging; urines obtained from diapers were not satisfactory. Urinary β2M concentrations increased significantly (P < .02) in the normal infants from the first day (0.36 ± 0.29 mg/L: n = 29) to the third day (0.60 ± 0.43 mg/L: n = 21) postpartum. Compared with the normal infants, values for the infants with meconium-stained amniotic fluid were increased significantly on days 1 (1.64 ± 2.16 mg/L: n = 25: P < .005) and 3 (2.12 ± 2.04 mg/L: n = 23: P < .005). Levels exceeded two standard deviations above the normal mean in 12 of the 26 infants with meconium-stained amniotic fluid on postpartum day 1, and 12 of the 23 infants with meconium-stained amniotic fluid on day 3. Urinary creatinine levels were similar in both the normal infants and those with meconium-stained amniotic fluid. All infants with meconium-stained amniotic fluid with a one-minute Apgar score of 6 or less had an elevated urinary β2M concentration. The elevated levels of urinary β2M in infants with meconium-stained amniotic fluid indicate the existence of tubular dysfunction, probably mild acute tubular necrosis secondary to hypoxia.

scholarly journals TUBULAR DYSFUNCTION IN INFANTS WITH MECONIUM STAINED AMNIOTIC FLUID - DIAGNOSIS USING B2 MICROGLOBULIN

1984 ◽  
Vol 18 ◽  
pp. 341A-341A
Author(s):  
Ronald J Portman ◽  
Jennifer W Cole ◽  
Jeffrey M Perlman ◽  
Yin Lim ◽  
Alan M Robson
Keyword(s):  
Amniotic Fluid ◽  
Tubular Dysfunction ◽  
Meconium Stained Amniotic Fluid

Adrenocorticotropic hormone and cortisol levels in term infants born with meconium-stained amniotic fluid

2014 ◽  
Vol 42 (6) ◽  
Author(s):  
Kaninghat Prasanth ◽  
Medha Kamat ◽  
Manhal Khilfeh ◽  
Vanessa Davis
Keyword(s):  
Respiratory Distress ◽  
Amniotic Fluid ◽  
Cord Blood ◽  
Adrenocorticotropic Hormone ◽  
Inadequate Response ◽  
Term Infants ◽  
Group 3 ◽  
Cortisol Levels ◽  
Group 2 ◽  
Meconium Stained Amniotic Fluid

AbstractTo evaluate cord blood concentrations of adrenocorticotropic hormone (ACTH) and cortisol in well term infants born with and without meconium-stained amniotic fluid (MSAF) and term infants born with MSAF who experienced respiratory distress (RD).This was a prospective observational study. Fifty-four term infants were enrolled in the study in three groups: group 1 consisted of 18 well infants who were born with clear amniotic fluid, group 2 had 18 well infants born with MSAF, and group 3 had 18 infants born with MSAF who experienced RD in the first 24 h of age. Cord blood ACTH and cortisol concentrations were measured in infants born in all three groups. Groups 2 and 3 had serum ACTH and cortisol levels re-measured at 22–26 h of age.The mean ACTH and cortisol levels at birth in group 3 infants were 18.3 pg/mL and 12.6 mg/dL, respectively. These were significantly lower than those in group 2 infants.Term infants born with MSAF and who experienced respiratory distress had significantly lower levels of ACTH and cortisol at birth compared with well term infants born with MSAF or clear amniotic fluid. This study suggests that inadequate response of ACTH and cortisol hormones may play a role in the development of respiratory distress in term infants with MSAF.

scholarly journals Ifosfamide nephrotoxicity in adult patients

2019 ◽  
Vol 13 (4) ◽  
pp. 660-665
Author(s):  
Gaël Ensergueix ◽  
Nicolas Pallet ◽  
Dominique Joly ◽  
Charlène Levi ◽  
Sophie Chauvet ◽  
...  
Keyword(s):  
Kidney Injury ◽  
Adult Patients ◽  
Tubular Dysfunction ◽  
Mitochondrial Toxicity ◽  
Kidney Dysfunction ◽  
Renal Epithelial Cells ◽  
Tubular Necrosis ◽  
Proximal Tubular ◽  
Histological Characteristics

Abstract Background Ifosfamide, a widely prescribed antineoplasic agent, is frequently associated with kidney dysfunction. Its nephrotoxicity is well documented in children, but data are lacking in adult patients. Methods The aim of this retrospective study was to describe the clinical, biological and histological characteristics of ifosfamide nephrotoxicity. Results We report 34 patients (median age: 41 years) admitted in six French nephrology departments for kidney failure and/or tubular dysfunction. Fifteen patients (44.1%) received cisplatin as part of their chemotherapy. In 6 patients (17.7%), ifosfamide nephrotoxicity was revealed by a proximal tubular dysfunction (PTD), in 5 patients (14.4%) by an acute kidney injury (AKI), in 6 patients (17.7%) by a chronic kidney disease (CKD) and in 17 patients (49.7%) by an association of PTD and AKI. Fourteen renal biopsies (41.2%) were performed and revealed acute tubular necrosis (85.7%), vacuolation (78.6%) and nuclear atypias (71.4%) of renal epithelial cells, interstitial inflammation (71.4%) and fibrosis (57.1%). Electron microscopy showed mitochondrial enlargement and dysmorphic changes suggestive of mitochondrial toxicity. Ten patients (29.4%) progressed to Stage 5 CKD, six (17.6%) required haemodialysis and six patients died during a median follow-up period of 31 months. Risk factors for Stage 5 CKD were age and cisplatin co-administration.

scholarly journals A Population-Based Study of Meconium Aspiration Syndrome in Neonates Born between 37 and 43 Weeks of Gestation

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
C. Fischer ◽  
C. Rybakowski ◽  
C. Ferdynus ◽  
P. Sagot ◽  
J. B. Gouyon
Keyword(s):  
Amniotic Fluid ◽  
Low Frequency ◽  
Population Based ◽  
Meconium Aspiration Syndrome ◽  
Population Based Study ◽  
Term Neonates ◽  
Meconium Aspiration ◽  
High Prevalence ◽  
Term Newborns ◽  
Meconium Stained Amniotic Fluid

The epidemiology of meconium aspiration syndrome (MAS) in term neonates is described in a population-based retrospective study of data recorded for all births from 2000 to 2007 in a French region (Burgundy). Of the 132 884 eligible term newborns, the rate of meconium-stained amniotic fluid (MSAF) was 7.93%. The prevalence of severe MAS was 0.067% in the overall population. MAS rate was 0.11% at 37-38 weeks of gestation (WG), 0.20% at 39–41 WG, and 0.49% at 42-43 WG. Factors independently associated with severe MAS were identified by a case-control study, that is, thick meconium amniotic fluid, fetal tachycardia, Apgar score ≤3 at 1 minute, and birth in a level III facility. Our results confirm the high prevalence of MSAF after 37 WG but also show the low frequency of severe MAS in a period corresponding to the new international recommendations on the management of birth with MSAF.

Significance of meconium stained amniotic fluid in the preterm population

1998 ◽  
Vol 5 (1) ◽  
pp. 167A-167A
Author(s):  
H SCOTT ◽  
M WALKER ◽  
L OPPENHEIMER ◽  
A GRUSLINGIROUX
Keyword(s):  
Amniotic Fluid ◽  
Meconium Stained Amniotic Fluid

PS-095a The Mean Platelet Volume In Infants With Meconium Stained Amniotic Fluid

2014 ◽  
Vol 99 (Suppl 2) ◽  
pp. A144.4-A145
Author(s):  
M Tekin ◽  
C Konca ◽  
Z Kahramaner ◽  
A Erdemir ◽  
A Gulyuz ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
The Mean ◽  
Meconium Stained Amniotic Fluid

scholarly journals Levels of Predominant Intestinal Microorganisms in 1 Month-Old Full-Term Babies and Weight Gain During the First Year of Life

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2412
Author(s):  
Sonia González ◽  
Marta Selma-Royo ◽  
Silvia Arboleya ◽  
Cecilia Martínez-Costa ◽  
Gonzalo Solís ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gut Microbiota ◽  
Early Life ◽  
Later Life ◽  
Full Term ◽  
First Year ◽  
Term Infants ◽  
Term Newborns ◽  
Infant Weight Gain ◽  
First Year Of Life

The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this early microbiota may constitute a target for the promotion of healthy neonatal growth and development with potential consequences for later life. Unfortunately, we are still far from understanding the association between neonatal microbiota and weight gain and growth. In this context, we evaluated the relationship between early microbiota and weight in a cohort of full-term infants. The absolute levels of specific fecal microorganisms were determined in 88 vaginally delivered and 36 C-section-delivered full-term newborns at 1 month of age and their growth up to 12 months of age. We observed statistically significant associations between the levels of some early life gut microbes and infant weight gain during the first year of life. Classifying the infants into tertiles according to their Staphylococcus levels at 1 month of age allowed us to observe a significantly lower weight at 12 months of life in the C-section-delivered infants from the highest tertile. Univariate and multivariate models pointed out associations between the levels of some fecal microorganisms at 1 month of age and weight gain at 6 and 12 months. Interestingly, these associations were different in vaginally and C-section-delivered babies. A significant direct association between Staphylococcus and weight gain at 1 month of life was observed in vaginally delivered babies, whereas in C-section-delivered infants, lower Bacteroides levels at 1 month were associated with higher later weight gain (at 6 and 12 months). Our results indicate an association between the gut microbiota and weight gain in early life and highlight potential microbial predictors for later weight gain.

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