LB2: Prospective study of the association between sleep disordered breathing and hypertensive disorders of pregnancy and gestational diabetes

2015 ◽  
Vol 212 (1) ◽  
pp. S424-S425 ◽  
Author(s):  
Francesca L. Facco
Keyword(s):  
Gestational Diabetes ◽  
Prospective Study ◽  
Sleep Disordered Breathing ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Disordered Breathing

scholarly journals Exploring Fetal Sex as a Risk Factor for Sleep Disordered Breathing and Its Complications in Pregnancy

2020 ◽  
Vol 4 ◽  
pp. 247028972094807
Author(s):  
Margaret H. Bublitz ◽  
Myriam Salameh ◽  
Laura Sanapo ◽  
Ghada Bourjeily
Keyword(s):  
Gestational Diabetes ◽  
Pregnancy Complications ◽  
Sleep Disordered Breathing ◽  
Pregnancy Induced Hypertension ◽  
Hypertensive Disorders Of Pregnancy ◽  
Fetal Sex ◽  
Hypertensive Disorders ◽  
Induced Hypertension ◽  
In Pregnancy ◽  
Disordered Breathing

Sleep disordered breathing (SDB) is a common, yet under-recognized and undertreated condition in pregnancy. Sleep disordered breathing is associated with pregnancy complications including preeclampsia, gestational diabetes, preterm birth, as well as severe maternal morbidity and mortality. The identification of risk factors for SDB in pregnancy may improve screening, diagnosis, and treatment of SDB prior to the onset of pregnancy complications. The goal of this study was to determine whether fetal sex increases risk of SDB in pregnancy. A cohort of singleton (N = 991) pregnant women were recruited within 24 to 48 hours of delivery and answered questions regarding SDB symptoms by questionnaire. Women who reported frequent loud snoring at least 3 times a week were considered to have SDB. Hospital records were reviewed to extract information on fetal sex and pregnancy complications including preeclampsia, pregnancy-induced hypertension, gestational diabetes, preterm delivery, and low birth weight. Women carrying male fetuses were significantly more likely to have SDB (β = .37, P = .01, OR: 1.45 [95% CI: 1.09-1.94]). Fetal sex was associated with increased risk of hypertensive disorders of pregnancy (defined as preeclampsia and/or pregnancy-induced hypertension) among women with SDB in pregnancy (β = .41, P = .02, OR: 1.51 [95% CI: 1.08-2.11]). Fetal sex did not increase risk of preterm birth, low birth weight, or gestational diabetes among women with SDB in pregnancy. Women carrying male fetuses were approximately 1.5 times more likely to report SDB in pregnancy compared to women carrying female fetuses, and women with pregnancy-onset SDB carrying male fetuses were 1.5 times more likely to have hypertensive disorders of pregnancy compared to women with SDB carrying female fetuses. Confirmation of fetal sex as a risk factor may, with other risk factors, play a role in identifying women at highest risk of SDB complications in pregnancy.

scholarly journals The presence of coexisting sleep-disordered breathing among women with hypertensive disorders of pregnancy does not worsen perinatal outcome

PLoS ONE ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. e0229568 ◽  
Author(s):  
Danielle L. Wilson ◽  
Mark E. Howard ◽  
Alison M. Fung ◽  
Fergal J. O’Donoghue ◽  
Maree Barnes ◽  
...  
Keyword(s):  
Perinatal Outcome ◽  
Sleep Disordered Breathing ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Disordered Breathing

scholarly journals Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0232287
Author(s):  
Danielle L. Wilson ◽  
Mark E. Howard ◽  
Alison M. Fung ◽  
Fergal J. O’Donoghue ◽  
Maree Barnes ◽  
...  
Keyword(s):  
Sleep Disordered Breathing ◽  
Maternal Outcomes ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Disordered Breathing

scholarly journals Sleep-disordered breathing in hypertensive disorders of pregnancy: a BMI-matched study

2018 ◽  
Vol 27 (5) ◽  
pp. e12656 ◽  
Author(s):  
Danielle L. Wilson ◽  
Susan P. Walker ◽  
Alison M. Fung ◽  
Gabrielle Pell ◽  
Fergal J. O'Donoghue ◽  
...  
Keyword(s):  
Sleep Disordered Breathing ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Matched Study ◽  
Disordered Breathing

scholarly journals The Role of HIV Infection in the Pathophysiology of Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy

2021 ◽  
Vol 8 ◽  
Author(s):  
Wendy N. Phoswa
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Hiv Infection ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Post Exposure Prophylaxis ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Increased Risk ◽  
Hiv Aids

Purpose of the Review: The main objective of this study is to investigate mechanisms associated with gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) in HIV infected pregnant women by looking how placental hormones such as (progesterone and prolactin) and basic haemostatic parameters are regulated in HIV infected pregnancies.Recent Findings: HIV/AIDS are a major global obstetric health burden that lead to increased rate of morbidity and mortality. HIV/AIDS has been associated with the pathophysiology of GDM and HDP. Increased risk of GDM due to highly active antiretroviral therapy (HAART) usage has been reported in HIV infected pregnancies, which causes insulin resistance in both pregnant and non-pregnant individuals. HAART is a medication used for lowering maternal antepartum viral load and pre-exposure and post-exposure prophylaxis of the infant. In pregnant women, HAART induces diabetogenic effect by causing dysregulation of placental hormones such as (progesterone and prolactin) and predispose HIV infected women to GDM. In addition to HIV/AIDS and GDM, Studies have indicated that HIV infection causes haemostatic abnormalities such as hematological disorder, deregulated haematopoiesis process and the coagulation process which results in HDP.Summary: This study will help on improving therapeutic management and understanding of the pathophysiology of GDM and HDP in the absence as well as in the presence of HIV infection by reviewing studies reporting on these mechanism.

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