Host-microbial interactions in the lactational period using antibiotic depleted specific pathogen free mice model

2022 ◽  
Vol 226 (1) ◽  
pp. S308-S309
Author(s):  
Adetola F. Louis-Jacques ◽  
Sarah Sniffen ◽  
Shaheda Urmi ◽  
Maureen Groer ◽  
Dominick J. Lemas
Keyword(s):  
Microbial Interactions ◽  
Specific Pathogen Free ◽  
Mice Model ◽  
Specific Pathogen

Laboratory Animal Research Centre (Larc) “A Specific Pathogen Free Rodent Facility” - Covid – 19 Pandemic Response Plan

2020 ◽  
Author(s):  
Muralitharan Shanmugakonar ◽  
Vijay Kanth Govindharajan ◽  
Kavitha Varadharajan ◽  
Hamda Al-Naemi
Keyword(s):  
Laboratory Animal ◽  
Animal Research ◽  
Research Centre ◽  
Functional Requirement ◽  
Specific Pathogen Free ◽  
Specific Pathogen ◽  
Response Plan ◽  
Pandemic Response ◽  
Operational Plan

Laboratory Animal Research Centre (LARC) has developed an early emergency operational plan for COVID-19 pandemic situation. Biosafety and biosecurity measures were planned and implemented ahead of time to check the functional requirement to prevent the infection. Identified necessary support for IT, transport, procurement, finance, admin and research to make the operations remotely and successfully.

scholarly journals Curcumin reduces enteric isoprostane 8-iso-PGF2α and prostaglandin GF2α in specific pathogen-free Leghorn chickens challenged with Eimeria maxima

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Victor M. Petrone-Garcia ◽  
Raquel Lopez-Arellano ◽  
Gabriela Rodríguez Patiño ◽  
Miriam Aide Castillo Rodríguez ◽  
Daniel Hernandez-Patlan ◽  
...  
Keyword(s):  
Pilot Study ◽  
Broiler Chickens ◽  
Solid Phase ◽  
Oxidation Products ◽  
Specific Pathogen Free ◽  
Post Challenge ◽  
Eimeria Maxima ◽  
Lipid Oxidation Products ◽  
Challenge Control ◽  
Specific Pathogen

AbstractThe purpose of this pilot study was to evaluate and determine the concentration of prostaglandin GF2α (PGF2α) and isoprostane 8‐iso‐PGF2α in plasma and intestine of specific pathogen-free (SPF) Leghorn chickens challenged with Eimeria maxima, with or without dietary supplementation of curcumin using solid‐phase microextraction and ultra‐performance liquid chromatography/tandem mass spectrometry. Eighty 1-day-old male SPF chickens were randomly allocated to one of four groups with four replicates (n = 5 chickens/replicate). Groups consisted of: (1) Control (no challenge), (2) Curcumin (no challenge), (3) Eimeria maxima (challenge), and (4) Eimeria maxima (challenge) + curcumin. At day 28 of age, all chickens in the challenge groups were orally gavaged with 40,000 sporulated E. maxima oocysts. No significant differences (P > 0.05) were observed in the groups regardless of the treatment or challenge with E. maxima. Enteric levels of both isoprostane 8‐iso‐PGF2α and PGF2α at 7 days and 9 days post-challenge were significantly increased (P < 0.01) compared to the non-challenge control chickens. Interestingly, the enteric levels of both isoprostane 8‐iso‐PGF2α and PGF2α at 7 days post-challenge were significantly reduced in chickens fed curcumin, compared to control chickens challenge with E. maxima. At 9 days post-challenge, only levels of isoprostane 8‐iso‐PGF2α in the enteric samples were significantly reduced in chickens challenged with E. maxima supplemented with curcumin, compared with E. maxima challenge chickens. No differences of isoprostane 8‐iso‐PGF2α or PGF2α were observed in plasma at both days of evaluation. Similarly, no significant differences were observed between the challenge control or chickens challenge with E. maxima and supplemented with curcumin at both times of evaluation. The results of this pilot study suggests that the antioxidant anti-inflammatory properties of curcumin reduced the oxidative damage and subsequent intestinal mucosal over-production of lipid oxidation products. Further studies to confirm and extend these results in broiler chickens are required.

scholarly journals Attenuated fibrosis in specific pathogen‐free microbiota in experimental cholestasis‐ and toxin‐induced liver injury

2019 ◽  
Vol 33 (11) ◽  
pp. 12464-12476 ◽  
Author(s):  
Sheida Moghadamrad ◽  
Mohsin Hassan ◽  
Kathy D. McCoy ◽  
Jorum Kirundi ◽  
Philipp Kellmann ◽  
...  
Keyword(s):  
Liver Injury ◽  
Specific Pathogen Free ◽  
Specific Pathogen ◽  
Experimental Cholestasis

Effect of In Ovo Administered Reovirus Vaccines on Immune Responses of Specific-Pathogen-Free Chickens

10.1637/7087 ◽  
2004 ◽  
Vol 48 (1) ◽  
pp. 224-228 ◽  
Author(s):  
Z. Y. Guo ◽  
J. J. Giambrone ◽  
Z. Liu ◽  
T. V. Dormitorio ◽  
Hongzhuan Wu
Keyword(s):  
Immune Responses ◽  
Specific Pathogen Free ◽  
In Ovo ◽  
Specific Pathogen

scholarly journals Characteristic Intestinal Microflora of Specific Pathogen-Free Mice Bred in Two Different Colonies and their Influence on Postnatal Murine Immunocyte Profiles

2005 ◽  
Vol 54 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Taizo NAGURA ◽  
Satoshi HACHIMURA ◽  
Shuichi KAMINOGAWA ◽  
Tsutomu ARITSUKA ◽  
Kikuji ITOH
Keyword(s):  
Intestinal Microflora ◽  
Specific Pathogen Free ◽  
Specific Pathogen

Oral colonization and cariogenicity of Streptococcus gordonii in specific pathogen-free TAN:SPFOM(OM)BR rats consuming starch or sucrose diets

2001 ◽  
Vol 46 (4) ◽  
pp. 323-333 ◽  
Author(s):  
J.M. Tanzer ◽  
L.K. Baranowski ◽  
J.D. Rogers ◽  
E.M. Haase ◽  
F.A. Scannapieco
Keyword(s):  
Streptococcus Gordonii ◽  
Specific Pathogen Free ◽  
Specific Pathogen ◽  
Oral Colonization
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